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This study aimed to evaluate the protective effects and mechanism of Lactobacillus plantarum (LW) isolated from Tibetan chickens against ST infection in broilers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>Eighty 1-day-old Arbor Acres broilers were randomly divided into four groups (n =\u00a020 per group): control (CC), LW supplementation (LW), ST infection (ST), and ST\u00a0+\u00a0LW treatment (PR). Broilers in LW and PR groups were orally administered 1\u00a0\u00d7\u00a010\u2078 CFU ml\u22121 LW from day 4 to day 21, and those in ST and PR groups were challenged with 1 \u00d7 10\u2078 CFU ml\u22121 ST from day 15 to day 18. Results showed that LW significantly alleviated ST-induced growth retardation, oxidative stress, and intestinal histological injury. Meanwhile, LW inhibited NF-\u03baB pathway to reduce intestinal inflammation, upregulated tight junction proteins to enhance intestinal barrier function, increased the abundance of Lactobacillus and Bacilli to optimize gut microbiota, and maintained taurine levels to regulate taurine and hypotaurine metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LW effectively protects broilers from ST infection via regulating intestinal immunity, barrier function, gut microbiota, and metabolism. LW can be used as a safe and effective probiotic to prevent ST infection in poultry, thus reducing food safety risks and ensuring public health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jambio\/lxag163","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:55:04Z","timestamp":1783598104000},"source":"Crossref","is-referenced-by-count":2,"title":["<i>Lactobacillus plantarum<\/i>\n                    protects broilers against\n                    <i>Salmonella<\/i>\n                    Typhimurium infection via modulating TLR4\/MyD88\/NF-\u03baB signaling pathway and gut microbiota"],"prefix":"10.1093","volume":"137","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Guizhou Police College , Guiyang 550000 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Min","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Huazhong Agricultural University , Wuhan 430070 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengen","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Huazhong Agricultural University , Wuhan 430070 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Huazhong Agricultural University , Wuhan 430070 ,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazul","family":"Nabi","sequence":"additional","affiliation":[{"name":"Faculty of Animal Husbandry and Veterinary Science, Sindh Agriculture University Tandojam Pakistan Department of Poultry Science, , Tandojam 70060 ,","place":["Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Guizhou Police College 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