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Disruptions to these interactions, such as those that follow enteric pathogen infection or administration of antibiotics, can lead to persistent pathophysiology, particularly if disruptions occur during early development in neonatal life. Here, we highlight the impacts of altered host-microbe interactions following insults across the life span and discuss emerging mechanisms of action promoting these disruptions (see Graphical Abstract). We also identify potential therapeutics to restore these important pathways and their mechanisms of action.<\/jats:p>","DOI":"10.1093\/jambio\/lxag237","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:02:02Z","timestamp":1789473722000},"source":"Crossref","is-referenced-by-count":0,"title":["Host-microbiome interactions and enteric pathogen infections\u2014from early-life to long-term impacts on gut-brain communication"],"prefix":"10.1093","volume":"137","author":[{"given":"M\u00e9lanie G","family":"Gareau","sequence":"first","affiliation":[{"name":"University of California, Davis Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, , Davis, CA 95616 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungjae","family":"Park","sequence":"additional","affiliation":[{"name":"University of California, Davis Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, , Davis, CA 95616 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6704-998X","authenticated-orcid":false,"given":"Kim E","family":"Barrett","sequence":"additional","affiliation":[{"name":"University of California, Davis Department of Physiology and Membrane Biology, School of Medicine, , Sacramento, CA 95817 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2026101409291030800_bib1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.immuni.2019.02.014","article-title":"A weaning reaction to microbiota is required for resistance to immunopathologies in the 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