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The Global Alliance for Genomics and Health TES standard is used for submitting analyses to TREs. Three logical layers support federated analytics: a Submission and Orchestration Layer outside the TRE accepts analyses and holds outputs for collection; a Controller Layer inside the TRE enforces local governance policies and manages disclosure control; and an Analysis Execution Layer governs the technical execution of approved analytics against sensitive data. An open-source reference implementation was developed and deployed in 2 real-world case studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five Safes TES was deployed to enable federated analytics within the Dementias Platform UK national research infrastructure. In a transcontinental deployment, federated analytics across 2 TREs hosted in Singapore was enabled by Submission and Orchestration Layers hosted in the United Kingdom, demonstrating multi-jurisdictional federated analytics without centralizing control or moving sensitive data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>By aligning open technical standards with established governance frameworks, the architecture supports heterogeneous TREs participating in federated analyses while preserving data sovereignty, institutional autonomy, and compliance with local governance requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Five Safes TES demonstrates how TRE federated analytics can be deployed as a routine research capability, rather than requiring bespoke technical development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jamia\/ocag160","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T11:16:48Z","timestamp":1788520608000},"source":"Crossref","is-referenced-by-count":0,"title":["Five safes task execution service: a standards-based architecture and reference implementation for secure federated analytics across trusted research environments"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0292-7972","authenticated-orcid":false,"given":"Tim","family":"Beck","sequence":"first","affiliation":[{"name":"Centre for Health Informatics, School of Medicine, University of Nottingham , Nottingham, NG7 2RD,","place":["United Kingdom"]},{"name":"NIHR Nottingham Biomedical Research Centre, University of Nottingham , Nottingham, NG7 2RD,","place":["United 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