{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T23:10:10Z","timestamp":1784675410421,"version":"3.55.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The \u201cProjections In Multiple Sclerosis\u201d (PRIMUS) project aims to develop a precision medicine platform enabling neurologists to support therapeutic decisions in multiple sclerosis by visualizing similar patient data in a reference database. We present a data integration method to combine randomized clinical trials (RCTs) and observational studies data and optimize the informativeness of the resulting database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>We developed an extract-transform-load data integration pipeline to combine 13 source databases: the \u201cmother\u201d and \u201chigh-definition\u201d cohorts from the French MS registry and 11 industrial RCTs (31 786 patients). We aimed to inform each treatment class initiation with at least 500 patients with a 2-year clinical and MRI follow-up. Our data integration strategy used every patient visit as a potential baseline time point to inform a specific neurologist\u2019 query to the platform, thus tailoring the actual analysis cohort to each visiting patient.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The PRIMUS database had 12 953 patients with at least one informative visit, using the per-visit integration. It could inform treatment initiation scenarios with at least 485 patients for glatiramer acetate and at most 1754 for natalizumab. For instance, our per-visit integration method identified 1306 patients in the high-definition cohort against 610 with the classical epidemiological per-patient integration. Although the mother cohort\u2019s longitudinal data were deemed sparse, we identified 6128 informative patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Neurologists would query the PRIMUS database through a web application to support discussions with their patients and the selection of disease-modifying treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our data integration pipeline enabled the creation of a highly informative reference database.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jamiaopen\/ooag039","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:29:37Z","timestamp":1776770977000},"source":"Crossref","is-referenced-by-count":1,"title":["PRIMUS: a precision medicine platform reusing clinical trials and registry data to support treatment selection in multiple sclerosis"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-5294","authenticated-orcid":false,"given":"Stanislas","family":"Demuth","sequence":"first","affiliation":[{"name":"Nantes Universit\u00e9, Nantes University Hopital, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, F-44000, France"},{"name":"University of Strasbourg Inserm CIC1434 Clinical Investigation Center, , Strasbourg, 67000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5735-0173","authenticated-orcid":false,"given":"Igor","family":"Faddeenkov","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Nantes University Hopital, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, F-44000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6148-4676","authenticated-orcid":false,"given":"Julien","family":"Paris","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Nantes University Hopital, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, F-44000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5726-9620","authenticated-orcid":false,"given":"Olivia","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Nantes University Hopital, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, F-44000, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4229-7873","authenticated-orcid":false,"given":"B\u00e9atrice","family":"Baciotti","sequence":"additional","affiliation":[{"name":"Biogen France S.A.S , Paris, 75000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8375-7530","authenticated-orcid":false,"given":"Marianne","family":"Payet","sequence":"additional","affiliation":[{"name":"Merck Sant\u00e9 S.A.S. Neurology, , Lyon, 69008,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-9261","authenticated-orcid":false,"given":"Romain","family":"Casey","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, , Lyon, 69000,","place":["France"]},{"name":"Hospices Civils de Lyon Service de Neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et Neuro-Inflammation, , Bron, 69677,","place":["France"]},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques , Lyon, 69003,","place":["France"]},{"name":"EUGENE DEVIC EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation , Bron, F-69677,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7337-7122","authenticated-orcid":false,"given":"Sandra","family":"Vukusic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, , Lyon, 69000,","place":["France"]},{"name":"Hospices Civils de Lyon Service de Neurologie, scl\u00e9rose en plaques, pathologies de la my\u00e9line et Neuro-Inflammation, , Bron, 69677,","place":["France"]},{"name":"Observatoire Fran\u00e7ais de la Scl\u00e9rose en Plaques , Lyon, 69003,","place":["France"]},{"name":"EUGENE DEVIC EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation , Bron, 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67000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-3553","authenticated-orcid":false,"given":"Anne","family":"Kerbrat","sequence":"additional","affiliation":[{"name":"University Hospital of Rennes Department of Neurology, , Rennes, 35000,","place":["France"]},{"name":"University of Rennes, Inria, CNRS Empenn U1228, INSERM, IRISA UMR 6074, , Rennes, 35000,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6113-6938","authenticated-orcid":false,"given":"David","family":"Laplaud","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9, Nantes University Hopital, Ecole Centrale Nantes, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, F-44000, France"},{"name":"University Hospital of Nantes Nantes Universit\u00e9, Department of Neurology, , Nantes, 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