{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:24:52Z","timestamp":1778617492013,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rifaximin, a semi-synthetic antimicrobial, does not present microbiological method described in official compendia, and there is a lack of literature on this topic. The quality control of antimicrobials is extremely important to evaluate the real potency of pharmaceutical products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A miniaturized turbidimetric method for determining the potency of rifaximin in tablets was developed and validated by turbidimetry, according to the international guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Escherichia coli ATCC 10536 IAL 2393, brain heart infusion (BHI) broth, inoculum at 8%, rifaximin in purified water with 20% ethanol at 5, 10, and 20\u2009\u03bcg\/mL and 530\u2009nm were used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The method was considered selective for rifaximin, as the adjuvants did not show activity; linear with correlation coefficients 0.9998 for standard and 0.9999 for sample; accurate with 99.73% recovery; precise with RSD less than 3%; and robust in the face of small variations in (i) rifaximin volume, (ii) proportion of ethanol, (iii) inoculum volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The method is considered adequate and safe to evaluate the potency of rifaximin in tablets, contemplating speed, low cost, low waste generation, and ease of operation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>This work usescurrent, sustainable, and green analytical chemistry and can be used in the routine analyses of rifaximin by laboratories and the pharmaceutical industry around the world.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsab017","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T15:25:08Z","timestamp":1611588308000},"page":"1049-1054","source":"Crossref","is-referenced-by-count":8,"title":["Miniaturized Microbiological Method to Determine the Potency of Rifaximin in Tablets"],"prefix":"10.1093","volume":"104","author":[{"given":"Clara Bersi Motta","family":"Correa","sequence":"first","affiliation":[{"name":"S\u00e3o Paulo State University, School of Pharmaceutical Sciences, Department of Drugs and Medicines , Araraquara, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Kogawa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Faculdade de Farm\u00e1cia, Laborat\u00f3rio de Controle de Qualidade , Goi\u00e2nia, Goi\u00e1s,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University, School of Pharmaceutical Sciences, Department of Drugs and Medicines , Araraquara, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9rida Regina Nunes","family":"Salgado","sequence":"additional","affiliation":[{"name":"S\u00e3o Paulo State University, School of Pharmaceutical Sciences, Department of Drugs and Medicines , Araraquara, SP,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"key":"2026041420220644800_qsab017-B1","volume-title":"European Pharmacopoeia. 9th Ed., Council of Europe,","year":"2011"},{"key":"2026041420220644800_qsab017-B2","year":"2018"},{"key":"2026041420220644800_qsab017-B4","first-page":"56","volume":"3","author":"Cariqueo","year":"2011","journal-title":"Revista Electr\u00f3nica Cient\u00edfica y Acad\u00e9mica de Cl\u00ednica Alemana"},{"key":"2026041420220644800_qsab017-B5","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/j.bmc.2004.02.027","volume":"12","author":"Martini","year":"2004","journal-title":"Bioorganic Med. 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