{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:26:10Z","timestamp":1791242770405,"version":"4.1.0"},"reference-count":75,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Traditional Chinese Medicine Resources Survey Project of China","award":["Z135080000022"],"award-info":[{"award-number":["Z135080000022"]}]},{"name":"Hebei Province Modern Agricultural Technology Innovation Team","award":["HBCT2018060205"],"award-info":[{"award-number":["HBCT2018060205"]}]},{"name":"Doctoral Research Fund of Hebei University of Chinese Medicine","award":["BSZ2020007"],"award-info":[{"award-number":["BSZ2020007"]}]},{"name":"Hebei Traditional Chinese Medicine scientific research","award":["2022365"],"award-info":[{"award-number":["2022365"]}]},{"name":"Hebei Traditional Chinese Medicine scientific research","award":["2022098"],"award-info":[{"award-number":["2022098"]}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2022423004"],"award-info":[{"award-number":["H2022423004"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Atractylodes chinensis (DC.) Koidz. (A. chinensis) is a perennial herbaceous plant that is widely used as a Chinese medicine herb for gastric diseases. However, the bioactive compounds of this herbal medicine have not been defined, and quality control is imperfect.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Although the method of quality evaluation method for A. chinensis by high-performance liquid chromatography (HPLC) fingerprinting has been reported in related papers, it remains unknown whether the chemical markers selected are representative of their clinical efficacy. To develop methods for qualitative analysis and improved quality evaluation of A. chinensis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>In this study, HPLC was used to establish fingerprints and conduct similarity evaluation. Principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to reveal the differences of these fingerprints. Network pharmacology was used to analyze the corresponding targets of the active ingredients. Meantime, an active ingredient\u2013target\u2013pathway network was constructed to investigate the characteristics of the medical efficacy of A. chinensis and to predict potential Q-markers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Combining network pharmacological effectiveness and composition specificity with the Q-marker concept, atractylodin (ATD), \u03b2-eudesmol, atractylenolide \u0399 (AT-I) and atractylenolide III (AT-III) were predicted to be potential Q-markers of A. chinensis that showed anti-inflammatory, antidepressant, anti-gastric, and antiviral effects by acting on 10 core targets and 20\u2009key pathways.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The HPLC fingerprinting method established in this study is straightforward, and the identified four active constituents can be used as Q-markers of A. chinensis. These findings facilitate effective quality evaluation of A. chinensis and suggest this approach could be applied to evaluate the quality of other herbal medicines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>The fingerprints of Atractylodis rhizoma were organically combined with network pharmacology to further clarify its criteria for quality control.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsad059","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T01:32:06Z","timestamp":1684546326000},"page":"1402-1413","source":"Crossref","is-referenced-by-count":18,"title":["Predictive Analysis of Quality Markers of Atractylodis Rhizoma Based on Fingerprint and Network Pharmacology"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6715-9364","authenticated-orcid":false,"given":"Yanyun","family":"Zhao","sequence":"first","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"},{"name":"Inner Mongolia University, Key Laboratory of Forage and Endemic Crop Biotechnology, Ministry of Education, College of Life Sciences , No.235 West College Road, Saihan District, Hohhot Inner Mongolia 010000, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1980-6392","authenticated-orcid":false,"given":"Xinxin","family":"Chang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1115-9290","authenticated-orcid":false,"given":"Xian","family":"Gu","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3586-6878","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-5191","authenticated-orcid":false,"given":"Yuguang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"},{"name":"Hebei Chemical and Pharmaceutical College , No. 88 Fangxing Road, Yuhua District, Shijiazhuang, Hebei Province 050026, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5791-2316","authenticated-orcid":false,"given":"Huiyong","family":"Fang","sequence":"additional","affiliation":[{"name":"Hebei University of Chinese Medicine, Traditional Chinese Medicine Processing Technology Innovation Center of Hebei Province; International Joint Research Center on Resource Utilization and Quality Evaluation of Traditional Chinese Medicine of Hebei Province , No. 326 Xinshi South Road, Qiaoxi District, Shijiazhuang, Hebei Province 050091, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,19]]},"reference":[{"key":"2023090111574531900_qsad059-B1","volume-title":"Atractylodes spp.: In Vitro Culture and the Evaluation of Micropropagated Plants for Sesquiterpenes and Acetylenic Compounds","author":"Hiraoka","year":"1993"},{"key":"2023090111574531900_qsad059-B2","volume-title":"Pharmacopoeia of the People\u2019s Republic of China Part One","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"2023090111574531900_qsad059-B3","volume-title":"Shen Nong Ben Cao Jing","author":"Anonymous","year":"2018"},{"key":"2023090111574531900_qsad059-B4","doi-asserted-by":"crossref","first-page":"e0151975","DOI":"10.1371\/journal.pone.0151975","volume":"11","author":"Ahmed","year":"2016","journal-title":"PLoS One"},{"key":"2023090111574531900_qsad059-B5","doi-asserted-by":"crossref","first-page":"110554","DOI":"10.1016\/j.biopha.2020.110554","volume":"131","author":"Liu","year":"2020","journal-title":"Biomed. Pharmacother"},{"key":"2023090111574531900_qsad059-B6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00384-019-03422-y","volume":"35","author":"Wang","year":"2020","journal-title":"Int. J. Colorectal Dis"},{"key":"2023090111574531900_qsad059-B7","first-page":"343","volume":"35","author":"Fen","year":"2015","journal-title":"South. Med. Univ"},{"key":"2023090111574531900_qsad059-B8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.jep.2010.05.040","volume":"130","author":"Kim","year":"2010","journal-title":"J. Ethnopharmacol"},{"key":"2023090111574531900_qsad059-B9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jep.2010.10.016","volume":"133","author":"Zhao","year":"2011","journal-title":"J. Ethnopharmacol"},{"key":"2023090111574531900_qsad059-B10","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1016\/j.vaccine.2009.02.002","volume":"27","author":"Li","year":"2009","journal-title":"S. Vaccine"},{"key":"2023090111574531900_qsad059-B11","first-page":"69","volume":"19","author":"Bae","year":"2005","journal-title":"Korean Med"},{"key":"2023090111574531900_qsad059-B12","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3109\/08923973.2014.968256","volume":"36","author":"Ji","year":"2014","journal-title":"Immunopharmacol. Immunotoxicol"},{"key":"2023090111574531900_qsad059-B13","doi-asserted-by":"crossref","first-page":"112432","DOI":"10.1016\/j.jep.2019.112432","volume":"249","author":"Chen","year":"2020","journal-title":"J. Ethnopharmacol"},{"key":"2023090111574531900_qsad059-B14","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.21037\/atm-21-4656","volume":"9","author":"Liu","year":"2021","journal-title":"Ann. Transl. Med"},{"key":"2023090111574531900_qsad059-B15","doi-asserted-by":"crossref","first-page":"113415","DOI":"10.1016\/j.jep.2020.113415","volume":"266","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol"},{"key":"2023090111574531900_qsad059-B16","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1142\/S0192415X2150049X","volume":"49","author":"Wu","year":"2021","journal-title":"Am. J. Chin. Med"},{"key":"2023090111574531900_qsad059-B17","first-page":"15","volume":"47","author":"Zhao","year":"2022","journal-title":"China J. Chin. Mater. Med"},{"key":"2023090111574531900_qsad059-B18","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.devcel.2016.06.018","volume":"38","author":"Xu","year":"2016","journal-title":"Dev. Cell"},{"key":"2023090111574531900_qsad059-B19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/jssc.201900365","volume":"43","author":"Liu","year":"2020","journal-title":"J. Sep. Sci"},{"key":"2023090111574531900_qsad059-B20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpba.2013.04.035","volume":"83","author":"Wang","year":"2013","journal-title":"J. Pharm. Biomed. Anal"},{"key":"2023090111574531900_qsad059-B21","doi-asserted-by":"crossref","first-page":"106715","DOI":"10.1016\/j.microc.2021.106715","volume":"170","author":"Li","year":"2021","journal-title":"Microchem. J"},{"key":"2023090111574531900_qsad059-B22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.chroma.2005.12.091","volume":"1112","author":"Xie","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"2023090111574531900_qsad059-B23","doi-asserted-by":"crossref","first-page":"720","DOI":"10.5740\/jaoacint.18-0306","volume":"102","author":"Li","year":"2019","journal-title":"J. AOAC Int"},{"key":"2023090111574531900_qsad059-B24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/jssc.200900653","volume":"33","author":"Liang","year":"2010","journal-title":"J. Sep. Sci"},{"key":"2023090111574531900_qsad059-B25","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/10942912.2022.2046052","volume":"25","author":"Yang","year":"2022","journal-title":"Int. J. Food. Prop"},{"key":"2023090111574531900_qsad059-B26","first-page":"107","volume":"8","author":"Zhang","year":"2016","journal-title":"Chin. Tradit. Herbal. Drugs"},{"key":"2023090111574531900_qsad059-B27","first-page":"2974268","volume":"2020","author":"Wang","year":"2020","journal-title":"Oxid. Med. Cell. Longev"},{"key":"2023090111574531900_qsad059-B28","doi-asserted-by":"crossref","first-page":"122102","DOI":"10.1016\/j.jchromb.2020.122102","volume":"1146","author":"Huang","year":"2020","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci"},{"key":"2023090111574531900_qsad059-B29","first-page":"1443","volume":"47","author":"Liu","year":"2016","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"2023090111574531900_qsad059-B30","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.phymed.2018.05.015","volume":"44","author":"Liu","year":"2018","journal-title":"Phytomedicine"},{"key":"2023090111574531900_qsad059-B31","first-page":"1","volume":"49","author":"Zhang","year":"2018","journal-title":"Chin. Tradit. Herb. Drugs"},{"key":"2023090111574531900_qsad059-B32","first-page":"872","volume":"34","author":"Xiao","year":"2018","journal-title":"J. Changchun Univ. Chin. Med"},{"key":"2023090111574531900_qsad059-B33","author":"Liu","year":"2017"},{"key":"2023090111574531900_qsad059-B34","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.plaphy.2018.07.016","volume":"130","author":"Zhou","year":"2018","journal-title":"Plant Physiol. Biochem"},{"key":"2023090111574531900_qsad059-B35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fitote.2016.08.017","volume":"114","author":"Xu","year":"2016","journal-title":"Fitoterapia"},{"key":"2023090111574531900_qsad059-B36","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/S0960-894X(00)00536-9","volume":"10","author":"Murakami","year":"2000","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"2023090111574531900_qsad059-B37","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.3390\/molecules23123234","volume":"23","author":"Xu","year":"2018","journal-title":"Molecules"},{"key":"2023090111574531900_qsad059-B38","doi-asserted-by":"crossref","first-page":"497532","DOI":"10.1155\/2013\/497532","volume":"2013","author":"Xia","year":"2013","journal-title":"J. Anal. Methods. Chem"},{"key":"2023090111574531900_qsad059-B39","first-page":"82","volume":"33","author":"Su","year":"2021","journal-title":"J. Jiangxi Univ. Chin. Med"},{"key":"2023090111574531900_qsad059-B40","first-page":"1314","volume":"31","author":"Sun","year":"2020","journal-title":"China Pharm"},{"key":"2023090111574531900_qsad059-B41","doi-asserted-by":"crossref","first-page":"120119","DOI":"10.1016\/j.saa.2021.120119","volume":"262","author":"Lei","year":"2021","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc"},{"key":"2023090111574531900_qsad059-B42","first-page":"598","volume":"38","author":"Li","year":"2018","journal-title":"Chin. J. Pharm. Anal"},{"key":"2023090111574531900_qsad059-B43","doi-asserted-by":"crossref","first-page":"e217522","DOI":"10.1371\/journal.pone.0217522","volume":"14","author":"Tsusaka","year":"2019","journal-title":"PLoS One"},{"key":"2023090111574531900_qsad059-B44","first-page":"1399","volume":"3","author":"Ouyang","year":"2020","journal-title":"J. Chin. Med. Mater"},{"key":"2023090111574531900_qsad059-B45","first-page":"1011","volume":"57","author":"Li","year":"2016","journal-title":"J. Tradit. Chin. Med"},{"key":"2023090111574531900_qsad059-B46","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.7150\/ijbs.45538","volume":"16","author":"Yang","year":"2020","journal-title":"Int. J. Biol. Sci"},{"key":"2023090111574531900_qsad059-B47","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13020-019-0244-y","volume":"14","author":"Zhang","year":"2019","journal-title":"Chin. Med"},{"key":"2023090111574531900_qsad059-B48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12272-021-01342-6","volume":"44","author":"Deng","year":"2021","journal-title":"Arch. Pharm. Res"},{"key":"2023090111574531900_qsad059-B49","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1111\/cbdd.13823","volume":"97","author":"Acharya","year":"2021","journal-title":"Chem. Biol. Drug. Des"},{"key":"2023090111574531900_qsad059-B50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13020-017-0157-6","volume":"13","author":"Xie","year":"2018","journal-title":"Chin. Med"},{"key":"2023090111574531900_qsad059-B51","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3390\/metabo9110260","volume":"9","author":"Kotawong","year":"2019","journal-title":"Metabolites"},{"key":"2023090111574531900_qsad059-B52","first-page":"226","volume":"37","author":"Ji","year":"2018","journal-title":"J. Pharm. Res"},{"key":"2023090111574531900_qsad059-B53","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1093\/jpp\/rgab036","volume":"73","author":"Acharya","year":"2021","journal-title":"J. Pharm. Pharmacol"},{"key":"2023090111574531900_qsad059-B54","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s40259-018-0320-3","volume":"32","author":"Avci","year":"2018","journal-title":"BioDrugs"},{"key":"2023090111574531900_qsad059-B55","doi-asserted-by":"crossref","first-page":"115327","DOI":"10.1016\/j.bmc.2020.115327","volume":"28","author":"Kaur","year":"2020","journal-title":"Bioorg. Med. Chem"},{"key":"2023090111574531900_qsad059-B56","doi-asserted-by":"crossref","first-page":"155577","DOI":"10.1016\/j.cyto.2021.155577","volume":"144","author":"Rose-John","year":"2021","journal-title":"Cytokine"},{"key":"2023090111574531900_qsad059-B57","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.3390\/molecules21091169","volume":"21","author":"Chae","year":"2016","journal-title":"Molecules"},{"key":"2023090111574531900_qsad059-B58","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3389\/fphar.2019.01505","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Pharmacol"},{"key":"2023090111574531900_qsad059-B59","doi-asserted-by":"crossref","first-page":"152922","DOI":"10.1016\/j.phymed.2019.152922","volume":"59","author":"Zhou","year":"2019","journal-title":"Phytomedicine"},{"key":"2023090111574531900_qsad059-B60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1021\/np100686a","volume":"74","author":"Kang","year":"2011","journal-title":"J. Nat. Prod"},{"key":"2023090111574531900_qsad059-B61","doi-asserted-by":"crossref","first-page":"e2001001","DOI":"10.1002\/cbdv.202001001","volume":"18","author":"Ren","year":"2021","journal-title":"Chem. Biodivers"},{"key":"2023090111574531900_qsad059-B62","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/exd.13454","volume":"27","author":"Fu","year":"2018","journal-title":"Exp. Dermatol"},{"key":"2023090111574531900_qsad059-B63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.bbrc.2014.05.110","volume":"450","author":"Ma","year":"2014","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2023090111574531900_qsad059-B64","doi-asserted-by":"crossref","first-page":"173735","DOI":"10.1016\/j.ejphar.2020.173735","volume":"891","author":"Bailly","year":"2021","journal-title":"Eur. J. Pharmacol"},{"key":"2023090111574531900_qsad059-B65","first-page":"7576292","volume":"2016","author":"De Tommaso","year":"2016","journal-title":"Behav. Neurol"},{"key":"2023090111574531900_qsad059-B66","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41572-021-00269-y","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2023090111574531900_qsad059-B67","first-page":"121","volume":"89","author":"Li","year":"2022","journal-title":"Neuro. Toxicol"},{"key":"2023090111574531900_qsad059-B68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-019-1655-5","volume":"17","author":"Zhu","year":"2020","journal-title":"J. Neuroinflamm"},{"key":"2023090111574531900_qsad059-B69","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cobeha.2019.02.004","volume":"28","author":"Turkiewicz","year":"2019","journal-title":"Curr. Opin. Behav. Sci"},{"key":"2023090111574531900_qsad059-B70","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1126\/science.abc3965","volume":"369","author":"Wargo","year":"2020","journal-title":"Science"},{"key":"2023090111574531900_qsad059-B71","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.cgh.2018.08.045","volume":"17","author":"Akshintala","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol"},{"key":"2023090111574531900_qsad059-B72","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/j.gastro.2020.09.057","volume":"160","author":"Shanahan","year":"2021","journal-title":"Gastroenterology"},{"key":"2023090111574531900_qsad059-B73","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1038\/d41586-020-00194-2","volume":"577","author":"Brody","year":"2020","journal-title":"Nature"},{"key":"2023090111574531900_qsad059-B74","volume-title":"School Notes","author":"Zhang","year":"2011"},{"key":"2023090111574531900_qsad059-B75","doi-asserted-by":"crossref","first-page":"665376","DOI":"10.3389\/fphar.2021.665376","volume":"12","author":"Qu","year":"2021","journal-title":"Front. Pharmacol"}],"container-title":["Journal of AOAC International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jaoac\/advance-article-pdf\/doi\/10.1093\/jaoacint\/qsad059\/50683882\/qsad059.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaoac\/article-pdf\/106\/5\/1402\/51311298\/qsad059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaoac\/article-pdf\/106\/5\/1402\/51311298\/qsad059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T12:16:42Z","timestamp":1693570602000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/106\/5\/1402\/7174134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,19]]},"references-count":75,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,19]]},"published-print":{"date-parts":[[2023,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jaoacint\/qsad059","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,10,1]]},"published":{"date-parts":[[2023,5,19]]}}}