{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:00:43Z","timestamp":1787763643276,"version":"build-2784847793"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The presentation of rhinitis has drawn increasing attention in recent years due to the possibility of overlap or confusion between allergic rhinitis symptoms and those of COVID-19. Azelastine hydrochloride (AZH) and mometasone furoate (MOF) are two of the most efficient combinations for enhancing the symptoms of seasonal allergic rhinitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This work concerns applying and validating different accurate and simple spectrophotometric approaches for simultaneous quantification of the binary mixture of AZH and MOF in raw material, laboratory-prepared mixtures, and pharmaceutical preparation. Moreover, assessment of the environmental impact of the applied approaches on the environment was also a key goal of this study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>AZH was determined using the direct spectrophotometric (D0) method, while four reliable spectrophotometric approaches namely, induced dual wavelength (IDW), ratio subtraction (RS), ratio difference (RD), and ratio derivative (1DD) were used for MOF determination.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The methods were validated in line with the International Conference of Harmonization standards. In the AZH range of (5\u201356\u2009\u00b5g\/mL) and MOF range of (2\u201320\u2009\u00b5g\/mL), the linearity of the proposed approaches was investigated with high accuracy findings. There were no significant differences between the obtained results and those of the reported method when compared statistically. Furthermore, the applied spectrophotometric methods were deemed to be eco-friendly according to Green Analytical Procedure Index (GAPI) and Analytical Greenness Calculator (AGREE) assessment metrics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The applied spectrophotometric methods are simpler, more eco-friendly, and take a shorter time to precisely estimate many measurements compared to the only reported chromatographic analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>Neither publications of novel spectrophotometric methods nor reported green ones have been available for simultaneous determination of the binary mixture of AZH and MOF, so this work has a great significance and novelty in the area of pharmaceutical analysis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsae016","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T08:19:57Z","timestamp":1709021997000},"page":"512-518","source":"Crossref","is-referenced-by-count":4,"title":["Different Eco-Friendly Spectrophotometric Approaches Including Direct and Manipulations of Zero and Ratio Spectra for Simultaneous Determination of Novel Nasal Spray Combination Used in Seasonal Allergic Rhinitis"],"prefix":"10.1093","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2519-9699","authenticated-orcid":false,"given":"Alaa","family":"Reda","sequence":"first","affiliation":[{"name":"Egyptian Russian University, Faculty of Pharmacy, Pharmaceutical Chemistry Department , Badr City, Cairo 11829, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-2749","authenticated-orcid":false,"given":"Hanaa","family":"Saleh","sequence":"additional","affiliation":[{"name":"Zagazig University, Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department , Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3012-0890","authenticated-orcid":false,"given":"Eman A","family":"Bahgat","sequence":"additional","affiliation":[{"name":"Zagazig University, Faculty of Pharmacy, Pharmaceutical Analytical Chemistry Department , Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3996-4582","authenticated-orcid":false,"given":"Michael Gamal","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Egyptian Russian University, Faculty of Pharmacy, Pharmaceutical Chemistry Department , Badr City, Cairo 11829, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"2024050308050518600_qsae016-B1","doi-asserted-by":"publisher","first-page":"e17646","DOI":"10.1016\/j.heliyon.2023.e13952","volume":"9","author":"Edwin","year":"2023","journal-title":"Heliyon"},{"key":"2024050308050518600_qsae016-B2","doi-asserted-by":"publisher","first-page":"q172","DOI":"10.1136\/bmj.p1833","volume":"384","author":"Looi","year":"2023","journal-title":"BMJ"},{"key":"2024050308050518600_qsae016-B3","doi-asserted-by":"publisher","first-page":"148","DOI":"10.4168\/aair.2011.3.3.148","volume":"3","author":"Tran","year":"2011","journal-title":"Allergy Asthma Immunol. 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