{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T22:44:10Z","timestamp":1782859450443,"version":"3.54.5"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Basic Scientific Research Business Expenses of Public Welfare Scientific Research Institutions in the Autonomous Region","award":["KY2020025"],"award-info":[{"award-number":["KY2020025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The leaves of Elaeagnus angustifolia, belonging to the Elaeagnaceae Juss. family, are known for their medicinal properties for relieving cough and asthma, as well as treating dysentery and diarrhea.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To establish a rapid qualitative method for the detection of secondary metabolites in leaves of Elaeagnus angustifolia, including the identification and analysis of various secondary metabolites in leaves of Elaeagnus angustifolia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Samples were separated using a Waters ACQUITY H-Class ultra-performance liquid chromatography (UPLC) system (FTN autosampler, quaternary LC pump) and ACQUITY UPLC\u00ae BEH C18 column (1.7\u2009\u03bcm, 2.1\u2009mm \u00d7 100\u2009mm). The flow rate was set to 0.4\u2009mL\/min, the injection volume was 1.0\u2009\u03bcL, and the column temperature was set to 45\u00b0C. The mobile phase was methanol (A) with \u22120.1% formic acid in water (B). Samples were analyzed by quadrupole time-of-flight mass spectrometry (Q-TOF-MS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 182 different secondary metabolites were detected from 10 varieties of leaves of Elaeagnus angustifolia, including 77 flavonoids, 20 steroids, 7 alkaloids, 15 amino acids, 18 organic acids, and 45 other compound types.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A method for the rapid analysis of leaves of Elaeagnus angustifolia by UPLC-Q-TOF-MS was established, and the secondary metabolites in leaves of Elaeagnus angustifolia were identified. The enrichment of secondary metabolites in leaves of different varieties of Elaeagnus angustifolia was clarified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>The UPLC-Q-TOF-MS method is very fast and possesses a high degree of selectivity, precision, and sensitivity. These findings provide a reliable foundation for the development of medicinal resources derived from Elaeagnus angustifolia leaves.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsae017","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T08:37:26Z","timestamp":1709195846000},"page":"90-103","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of Secondary Metabolites of <i>Elaeagnus Angustifolia<\/i> Leaves Based on UPLC-Q-TOF-MS"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0908-469X","authenticated-orcid":false,"given":"Jinfa","family":"Liao","sequence":"first","affiliation":[{"name":"Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy , Shihezi 832002,","place":["China"]},{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Sheng","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy , Shihezi 832002,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silin","family":"Yu","sequence":"additional","affiliation":[{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]},{"name":"Harbin Medical University, College of Pharmacy , Harbin 150081","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongzhi","family":"Yin","sequence":"additional","affiliation":[{"name":"Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy , Shihezi 832002,","place":["China"]},{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, College of Pharmacy , Shihezi 832002,","place":["China"]},{"name":"Xinjiang Academy of Forestry, Key Laboratory of Forest Resources and Utilization in Xinjiang of National Forestry and Grassland Administration, Key Laboratory Of Fruit Tree Species Breeding And Cultivation in Xinjiang , Urumqi 830052,","place":["China"]},{"name":"Harbin Medical University, College of Pharmacy , Harbin 150081","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"2025012518160550000_qsae017-B1","first-page":"451","volume":"55","year":"2004","journal-title":"Taxon"},{"key":"2025012518160550000_qsae017-B2","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13007-022-00915-w","volume":"18","author":"Mao","year":"2022","journal-title":"Plant Methods"},{"key":"2025012518160550000_qsae017-B3","first-page":"5","volume":"39","author":"Ma","year":"2021","journal-title":"Nord. J. Bot"},{"key":"2025012518160550000_qsae017-B4","doi-asserted-by":"crossref","first-page":"112795","DOI":"10.1016\/j.phytochem.2021.112795","volume":"188","author":"Yuca","year":"2021","journal-title":"Phytochemistry"},{"key":"2025012518160550000_qsae017-B5","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2174\/1389201020666191107112243","volume":"22","author":"Sabouri","year":"2021","journal-title":"Curr. Pharm. Biotechnol"},{"key":"2025012518160550000_qsae017-B6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jtcme.2015.09.004","volume":"7","author":"Hamidpour","year":"2017","journal-title":"J. Tradit. Complement. Med"},{"key":"2025012518160550000_qsae017-B7","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.3390\/molecules25092021","volume":"25","author":"Carradori","year":"2020","journal-title":"Molecules"},{"key":"2025012518160550000_qsae017-B8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.indcrop.2018.04.051","volume":"121","author":"Mahboubi","year":"2018","journal-title":"Ind. Crops Prod"},{"key":"2025012518160550000_qsae017-B9","doi-asserted-by":"crossref","first-page":"736461","DOI":"10.1016\/j.aquaculture.2021.736461","volume":"536","author":"Hoseini","year":"2021","journal-title":"Aquaculture"},{"key":"2025012518160550000_qsae017-B10","first-page":"31","volume":"2","author":"Farahbakhsh","year":"2011","journal-title":"Basic Clin. Neurosci"},{"key":"2025012518160550000_qsae017-B11","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.ctim.2014.07.004","volume":"22","author":"Nikniaz","year":"2014","journal-title":"Complement. Ther. Med"},{"key":"2025012518160550000_qsae017-B12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15226\/csroa.2019.00151","volume":"6","author":"Hamidpour","year":"2019","journal-title":"CSROA"},{"key":"2025012518160550000_qsae017-B13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1017\/inp.2019.16","volume":"12","author":"Gaskin","year":"2019","journal-title":"Invasive Plant Sci. Manag"},{"key":"2025012518160550000_qsae017-B14","doi-asserted-by":"crossref","first-page":"106587","DOI":"10.1016\/j.agwat.2020.106587","volume":"245","author":"Dong","year":"2021","journal-title":"Agric. Water Manag"},{"key":"2025012518160550000_qsae017-B15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/agronomy12040913","volume":"12","author":"Pan","year":"2022","journal-title":"Agronomy"},{"key":"2025012518160550000_qsae017-B16","first-page":"175","volume":"17","author":"Zamani Kebrabadi","year":"2019","journal-title":"(Elaeagnus Angustifolia L.). Environ. Sci"},{"key":"2025012518160550000_qsae017-B17","first-page":"589","volume":"50","author":"Mehrabani Natanzi","year":"2012","journal-title":"Acta Med. Iran"},{"key":"2025012518160550000_qsae017-B18","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0378-8741(00)00222-1","volume":"72","author":"Ahmadiani","year":"2000","journal-title":"J. Ethnopharmacol"},{"key":"2025012518160550000_qsae017-B19","first-page":"29","volume":"4","author":"Taheri","year":"2010","journal-title":"J. Dent. Res. Dent. Clin. Dent. Prospects"},{"key":"2025012518160550000_qsae017-B20","doi-asserted-by":"crossref","first-page":"8230","DOI":"10.1021\/acs.jafc.3c00823","volume":"71","author":"Hu","year":"2023","journal-title":"J. Agric. Food Chem"},{"key":"2025012518160550000_qsae017-B21","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3390\/foods11010004","volume":"11","author":"Huang","year":"2021","journal-title":"Foods"},{"key":"2025012518160550000_qsae017-B22","first-page":"146","volume":"4","author":"Abri","year":"2016","journal-title":"Iran. Chem. Commun"}],"container-title":["Journal of AOAC International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jaoac\/advance-article-pdf\/doi\/10.1093\/jaoacint\/qsae017\/60660401\/qsae017.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaoac\/article-pdf\/108\/1\/90\/60660401\/qsae017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jaoac\/article-pdf\/108\/1\/90\/60660401\/qsae017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,25]],"date-time":"2025-01-25T18:16:22Z","timestamp":1737828982000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jaoac\/article\/108\/1\/90\/7616137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,28]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,28]]},"published-print":{"date-parts":[[2025,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jaoacint\/qsae017","relation":{},"ISSN":["1060-3271","1944-7922"],"issn-type":[{"value":"1060-3271","type":"print"},{"value":"1944-7922","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,1]]},"published":{"date-parts":[[2024,2,28]]}}}