{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:04:52Z","timestamp":1792569892265,"version":"4.5.0"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016931","name":"Institute of Marine Research","doi-asserted-by":"publisher","award":["15318"],"award-info":[{"award-number":["15318"]}],"id":[{"id":"10.13039\/100016931","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Determining the concentration of nanoparticles (NPs) in marine organisms is important for evaluating their environmental impact and to assess potential food safety risks to human health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The current work aimed at developing an in-house method based on single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) suitable for surveillance of NPs in mussels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A new low-cost and simple protease mixture was utilized for sample digestion, and novel open-source data processing was used, establishing detection limits on a statistical basis using false-positive and false-negative probabilities. The method was validated for 30 and 60\u2009nm gold NPs spiked to mussels as a proxy for seafood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Recoveries were 76\u201377% for particle mass concentration and 94\u2013101% for particle number concentration. Intermediate precision was 8\u20139% for particle mass concentration and 7\u20138% for particle number concentration. The detection limit for size was 18\u2009nm, for concentration 1.7\u2009ng\/g, and 4.2 \u00d7 105 particles\/g mussel tissue.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The performance characteristics of the method were satisfactory compared with numeric Codex criteria. Further, the method was applied to titanium-, chromium- and copper-based particles in mussels.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>The method demonstrates a new practical and cost-effective sample treatment, and streamlined, transparent, and reproducible data treatment for the routine surveillance of NPs in mussels.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsae024","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T02:44:18Z","timestamp":1710816258000},"page":"608-616","source":"Crossref","is-referenced-by-count":7,"title":["Validation of a Method for Surveillance of Nanoparticles in Mussels Using Single-Particle Inductively Coupled Plasma-Mass Spectrometry"],"prefix":"10.1093","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7425-5426","authenticated-orcid":false,"given":"Are","family":"Bruvold","sequence":"first","affiliation":[{"name":"Institute of Marine Research (IMR) , PO Box 1870 Nordnes , N-5817 Bergen, Norway"},{"name":"University of Bergen, Department of Chemistry , PO Box 7803 , N-5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Valdersnes","sequence":"additional","affiliation":[{"name":"Institute of Marine Research (IMR) , PO Box 1870 Nordnes , N-5817 Bergen, Norway"},{"name":"University of Bergen, Department of Chemistry , PO Box 7803 , N-5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1741-8406","authenticated-orcid":false,"given":"Katrin","family":"Loeschner","sequence":"additional","affiliation":[{"name":"Technical University of Denmark, National Food Institute , Kemitorvet 201 , DK-2800 Kgs Lyngby, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-5243","authenticated-orcid":false,"given":"Andr\u00e9 Marcel","family":"Bienfait","sequence":"additional","affiliation":[{"name":"Institute of Marine Research (IMR) , PO Box 1870 Nordnes , N-5817 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"2024070607312073800_qsae024-B1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.envpol.2013.11.014","volume":"186","author":"Baker","year":"2014","journal-title":"Environ. 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