{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:46:23Z","timestamp":1791557183190,"version":"4.3.4"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The presence of veterinary drug residues in food-producing animals and animal products is regulated through the enforcement of maximum residue limits (MRLs). To answer the need of the food sector to monitor these substances in a wide range of food commodities, stakeholders at AOAC INTERNATIONAL identified the need for a reliable confirmatory screening method. Such a qualitative approach is required for compliance checking and to support product release in manufacturing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Data were collected from five independent laboratories that applied the First Action Official Method\u20022020.04 to demonstrate adequate performance under reproducibility conditions. The probability of detection (POD) was calculated in blank test samples and test samples spiked at the screening target concentration (STC) level, with the objective to achieve PODs \u226410% and \u226590%, respectively. Additionally, the effectiveness of the screening method was evaluated by participating in 92 proficiency tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Four streams were optimized to screen for 152 veterinary drug residues by LC\u2013MS\/MS in a wide variety of food commodities including milk-based ingredients and related products (e.g., milk fractions, infant formula, infant cereals, and baby foods), meat- and fish-based ingredients and related products (fresh, powdered, cooked, infant cereals, and baby foods), and other ingredients based on eggs, animal fat, and animal byproducts. The four streams covered 105 antibiotic residues, anti-inflammatory and antiparasitic agents (stream A), 23 beta-lactams (stream B), 14 aminoglycosides (stream C), and 10 tetracyclines (Stream D).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The multilaboratory validation led to PODs at the STC \u226594% and PODs in the blank \u22649%. Further application of the multilaboratory validated method to 92 proficiency tests provided more than 99% satisfactory submitted results (n\u2009=\u2009784).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The interlaboratory reproducibility determined for this method met the acceptance criteria defined in AOAC Standard Method Performance Requirement (SMPR\u00ae) 2018.010.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>AOAC has approved the method for Final Action status.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsae032","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T02:52:07Z","timestamp":1713322327000},"page":"617-631","source":"Crossref","is-referenced-by-count":7,"title":["Screening of 152 Veterinary Drug Residues in Animal Source Foods by LC\u2013MS\/MS, Multilaboratory Validation Study: Final Action 2020.04"],"prefix":"10.1093","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-5323","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Desmarchelier","sequence":"first","affiliation":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 , Route du Jorat 57 , Lausanne 1000, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-9796","authenticated-orcid":false,"given":"Thomas","family":"Bessaire","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 , Route du Jorat 57 , Lausanne 1000, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-0648","authenticated-orcid":false,"given":"Marie-Claude","family":"Savoy","sequence":"additional","affiliation":[{"name":"Soci\u00e9t\u00e9 des Produits Nestl\u00e9 , Route du Jorat 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