{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:02:35Z","timestamp":1790308955738,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFF1104900"],"award-info":[{"award-number":["2023YFF1104900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Administration for Market Regulation","award":["QNBJ201313"],"award-info":[{"award-number":["QNBJ201313"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>As a new cosmetic ingredient, NMN is widely used in cosmetics production, but due to the lack of a detection method, QC of related products cannot be achieved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study will develop a detection method for NMN in three matrixes (facial mask essence, emulsion, and cream) for QC of related cosmetics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Given the high ester content in facial emulsions and creams, which can hinder the detection of trace substances, a novel multi-plug filtration clean-up (m-PFC) purification column packed with multi-walled carbon nanotubes (MWCNTs) was employed to purify these matrixes. An HPLC method for NMN in three matrixes (facial mask essence, emulsion, and cream) was established. Methodological verification was conducted.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Results demonstrated a good linear relationship within a range of 5.0\u2013500\u2009\u03bcg\/mL, with an LOQ of 5.0\u2009mg\/kg. The RSD of the precision experiment was less than 3%, and the RSD for six repeated experiments ranged from 1.2 to 5.3%, indicating the method's stability, reliability, and good repeatability. Recovery rates in the three cosmetic matrixes were between 93.9 and 109.4%, with an RSD below 3.7%. This method was applied to detect NMN content in seven cosmetics purchased from an e-commerce platform; NMN was not detected in some products claiming to contain NMN.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This method had the advantages of simple operation, high sensitivity, and good accuracy, and provides technical support for cosmetic regulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Highlights<\/jats:title>\n                  <jats:p>Through this study, we should raise awareness and supervision of NMN cosmetics by establishing relevant standards.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsaf017","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T02:34:16Z","timestamp":1744079656000},"page":"489-496","source":"Crossref","is-referenced-by-count":4,"title":["Method Development for Determining \u03b2-Nicotinamide Mononucleotide (NMN) in Cosmetics Using m-PFC\u2013HPLC"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5306-5826","authenticated-orcid":false,"given":"Tao","family":"Lan","sequence":"first","affiliation":[{"name":"Sub-Institute of Agricultural Food Standardization, China National Institute of Standardization , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9992-3965","authenticated-orcid":false,"given":"Wenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Sub-Institute of Agricultural Food Standardization, China National Institute of Standardization , Beijing 100191,","place":["China"]},{"name":"College of Chemistry and chemical engineering, Qiqihar University , Qiqihar 161006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-5568","authenticated-orcid":false,"given":"Hongtao","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Chemistry and chemical engineering, Qiqihar University , Qiqihar 161006,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3750-4371","authenticated-orcid":false,"given":"Zhenyu","family":"Yun","sequence":"additional","affiliation":[{"name":"Sub-Institute of Agricultural Food Standardization, China National Institute of Standardization , Beijing 100191,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9734-7761","authenticated-orcid":false,"given":"Bin","family":"Qu","sequence":"additional","affiliation":[{"name":"Beijing Knorth Co. 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