{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:19:09Z","timestamp":1793312349559,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Ascorbyl palmitate (AP) and ascorbyl stearate (AS), together called ascorbyl esters, are antioxidants that are used as food additives to prolong the shelf-life of foods by protecting against deterioration caused by oxidation.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This article aimed to develop a simple solvent extraction and LC-MS\/MS method for the determination of AP and AS in a broad range of food matrices.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n AP and AS in foods were extracted with methanol containing 0.5% (w\/v) L-ascorbic acid and analyzed by liquid chromatography\u2013tandem mass spectrometry in negative electrospray ionization and multiple reaction monitoring (MRM) mode.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The method was able to quantitatively detect AP and AS in different food matrices (canned drink, dessert, frozen fish, herbs, oils, infant formula\/formulated products, etc.) with recoveries of AP and AS at 73\u2013113% and 75\u2013113%, respectively, and the corresponding relative standard deviations (RSDs) of 0.3\u201316.1% and 0.2\u201313.7%. The limits of quantitation were 0.23\u2009mg\/kg for AP and 0.14\u2009mg\/kg for AS. Method applicability was also demonstrated by the detection of AP in powdered infant formula purchased from local market.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n A simple solvent extraction and LC-MS\/MS method was developed, validated, and demonstrated for the quantitative determination of AP and AS in various foods.<\/jats:p>\n <\/jats:sec>\n \n Highlights<\/jats:title>\n The validated method based on solvent extraction with LC-MS\/MS detection offered a fast and simple method for the analysis of AP and AS in a wide range of foods.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsaf069","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T11:20:41Z","timestamp":1753096841000},"page":"886-892","source":"Crossref","is-referenced-by-count":2,"title":["Determination of Ascorbyl Palmitate and Ascorbyl Stearate in Foods by LC-MS\/MS"],"prefix":"10.1093","volume":"108","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4015-3118","authenticated-orcid":false,"given":"Lai-Sheung","family":"Choi","sequence":"first","affiliation":[{"name":"Government Laboratory, Analytical and Advisory Services Division , 7\/F, Ho Man Tin Government Offices, 88 Chung Hau Street , Ho Man Tin, Kowloon, Hong Kong Special Administrative Region,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sau-Fong","family":"Chan","sequence":"additional","affiliation":[{"name":"Government Laboratory, Analytical and Advisory Services Division , 7\/F, Ho Man Tin Government Offices, 88 Chung Hau Street , Ho Man Tin, Kowloon, Hong Kong Special Administrative Region,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin-Wai","family":"Yeung","sequence":"additional","affiliation":[{"name":"Government Laboratory, Analytical and Advisory Services Division , 7\/F, Ho Man Tin Government Offices, 88 Chung Hau Street , Ho Man Tin, Kowloon, Hong Kong Special Administrative Region,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"2025110116210519500_qsaf069-B1","author":"FAO and WHO"},{"key":"2025110116210519500_qsaf069-B2","author":"FAO and WHO. 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