{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:01:20Z","timestamp":1790190080396,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stauntonia hexaphylla (Thunb.) Decne. is a medicinal plant widely distributed in Korea, Japan, and China, where it has long been used in traditional medicine to treat various ailments. Although numerous studies have investigated its phytochemical constituents and pharmacological potential, a comprehensive review summarizing the current knowledge on its botany, phytochemical constituents, and biological activities is still lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This review provides a comprehensive summary of the phytochemical constituents, botanical characteristics, distribution, and pharmacological activities reported for S. hexaphylla.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Relevant literature was collected from several electronic databases, including Web of Science, SciFinder, PubMed, and ScienceDirect. The keywords used in the search strategy included \u201cStauntonia hexaphylla (Thunb.) Decne,\u201d \u201cStauntonia hexaphylla,\u201d \u201cS. hexaphylla,\u201d \u201cphytochemical constituents,\u201d \u201cbotanical characteristics,\u201d \u201cdistribution,\u201d and \u201cbiological activities.\u201d<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>To date, 115 secondary metabolites have been identified from this plant, including 25 triterpenoids, 47 saponins, 21 flavonoids, 14 phenolic compounds, 3 lignans, and 5 other compounds. Pharmacological investigations have revealed diverse biological activities, including anti-inflammatory, anti-osteoporotic, anti-prostatic hyperplasia, antidepressant, anti-fatigue, anti-postmenopausal, anti-alopecia, and antidiabetic effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The findings highlight the rich phytochemical diversity and broad pharmacological potential of S. hexaphylla, supporting its continued investigation as a valuable medicinal resource and a promising source of bioactive compounds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Highlights<\/jats:title>\n                    <jats:p>A total of 115 secondary metabolites have been identified from S. hexaphylla, with saponins representing the major phytochemical constituents. The plant also exhibits diverse biological activities, particularly notable anti-inflammatory and anti-osteoporotic effects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jaoacint\/qsag079","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T11:18:27Z","timestamp":1786706307000},"source":"Crossref","is-referenced-by-count":0,"title":["A comprehensive review of phytochemical constituents and biological activities of\n                    <i>Stauntonia hexaphylla<\/i>\n                    (Thunb.) 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