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Pigs were individually housed and randomly allotted to four treatments in a 2 \u00d7 2 factorial arrangement (n = 20\/factor, 0% or 30% DDGS and 0 or 1,500 endo-pentosanase unit\/kg xylanase as two factors) based on sex and initial BW. Feed intake and BW were recorded weekly. On day 15 of the study, TiO2 in diets (0.3%) was used as an indigestible marker to calculate apparent ileal digestibility (AID). Plasma samples were collected on day 19 to measure tumor necrosis factor-alpha (TNF-\u03b1), malondialdehyde, and peptide YY. On day 21, all pigs were euthanized to collect tissues from duodenum, jejunum, and colon to measure morphology, TNF-\u03b1, and malondialdehyde concentrations. Distal jejunal digesta were collected to measure viscosity. Ileum digesta were collected to measure AID of nutrients. During the entire period, supplemental xylanase increased (P &amp;lt; 0.05) average daily gain (ADG; 616 to 660 g\/d) of nursery pigs, whereas DDGS (0 or 30%) did not affect ADG. On week 3, average daily feed intake (ADFI) was increased (P &amp;lt; 0.05) when fed DDGS (1,141 to 1,267 g\/d) and there was an interaction (P &amp;lt; 0.05) between two factors indicating that supplemental xylanase decreased ADFI when DDGS was used in a diet. Use of DDGS increased (P &amp;lt; 0.05) viscosity [1.86 to 2.38 centipoise (cP)], whereas supplemental xylanase reduced (P &amp;lt; 0.05) viscosity (2.27 to 1.96 cP) of jejunal digesta. The AID of dry matter (DM) and gross energy (GE) were improved (P &amp;lt; 0.05) by supplemental xylanase. Plasma TNF-\u03b1 was decreased (P &amp;lt; 0.05, 108.5 to 69.9 pg\/mL) by supplemental xylanase. Use of DDGS reduced (P &amp;lt; 0.05) villus height:crypt depth ratio (1.46 to 1.27), whereas supplemental xylanase increased (P &amp;lt; 0.05) the crypt depth (360 to 404 \u00b5m) in duodenum. In conclusion, feeding a diet with 30% DDGS to nursery pigs for 3 wk had no negative effect on growth performance, whereas reduced AID of DM and GE, increased TNF-\u03b1 level in colon tissue, and reduced the ratio of villus height to crypt depth. Dietary supplementation of xylanase reduced digesta viscosity improving AID of nutrients, reduced inflammatory response, and altered intestinal morphology, collectively improving ADG of nursery pigs regardless of the use of DDGS in a diet.<\/jats:p>","DOI":"10.1093\/jas\/skaa185","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T05:05:44Z","timestamp":1591333544000},"source":"Crossref","is-referenced-by-count":53,"title":["Effects of supplemental xylanase on health of the small intestine in nursery pigs fed diets with corn distillers\u2019 dried grains with solubles"],"prefix":"10.1093","volume":"98","author":[{"given":"Hongyu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"2020082603270564200_CIT0001","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1541-4337.2010.00135.x","article-title":"Xylooligosaccharides (XOS) as an emerging prebiotic: Microbial synthesis, utilization, structural characterization, bioactive properties, and applications","volume":"10","author":"Aachary","year":"2011","journal-title":"Compr. 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