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Previously published data have shown the efficacy of fluorescein isothiocyanate dextran (FITC-d; 4.17 mg\/kg) as a marker of enteric inflammation and mucosal barrier function in multiple species. Fluorescein is a smaller, less expensive alternative molecule possessing similar properties. The following two experiments compared FITC-d and fluorescein as potential indicators of intestinal permeability in pre- and postweaned lambs administered daily intramuscular injections of dexamethasone (Dex; 0.1 mg\/kg) for 1 wk. Experiment 1 consisted of five preweaned lambs that were placed in one of two treatment groups: fluorescein with Dex (F+Dex) or fluorescein only (F). On day 7, blood was collected before and 1 h after oral administration of fluorescein (50 mg\/kg). Experiment 2 included 12 weaned lambs and four treatment groups: F+Dex, F, FITC-d with Dex (Fd+Dex), and FITC-d only (Fd). On day 7, blood was collected before and 2 h after oral administration of FITC-d (4.17 mg\/kg) or fluorescein (50 mg\/kg). Plasma fluorescence was reported as the ratio between T1h\/T0 or T2h\/T0 for experiment 1 or 2, respectively. Experiment 1 showed a significant increase in T1h\/T0 ratio of F+Dex relative to F lambs (P = 0.05) indicative of increased leaky gut; however, no differences (P = 0.22) were obtained in experiment 2. Results of these experiments suggest fluorescein may serve as a suitable marker of enteric permeability in preruminant lambs, but not in those with functional rumens.<\/jats:p>","DOI":"10.1093\/jas\/skaa198","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T02:33:35Z","timestamp":1592706815000},"source":"Crossref","is-referenced-by-count":3,"title":["Technical note: fluorescein as an indicator of enteric mucosal barrier function in preruminant lambs"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4825-2915","authenticated-orcid":false,"given":"Audrey F","family":"Duff","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Wooster, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa R","family":"Bielke","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Wooster, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-3037","authenticated-orcid":false,"given":"Alejandro E","family":"Relling","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Wooster, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,6,20]]},"reference":[{"key":"2020070309240358000_CIT0001","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.rvsc.2016.09.015","article-title":"Inflammatory biomarkers are associated with ketosis in periparturient Holstein cows","volume":"109","author":"Abuajamieh","year":"2016","journal-title":"Res. 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