{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:26Z","timestamp":1787009066817,"version":"build-2736575974"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T00:00:00Z","timestamp":1595030400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dietary lysophospholipids (LPL) would influence milk composition of sows, thus positively affect intestinal health of offspring. The objective of this study was to determine effects of dietary LPL fed to lactating sows on performance, milk characteristics, gut health, and gut-associated microbiome of offspring. Sixty pregnant sows were allotted to 2 treatments in a randomized complete block design with parity and BW as blocks on day 110 of gestation. Treatments were CON (no added LPL) and LPL (0.05% LPL; Lipidol-Ultra, Pathway Intermediates, Shrewsbury, UK). Sows were fed 2 kg\/d from day 110 of gestation until farrowing and ad libitum after farrowing. Diets were formulated to meet NRC requirement for lactating sows. Colostrum and milk samples from 12 sows per treatment were collected to measure nutrients and immunoglobulins on days 1 and 18 of lactation, respectively. Twelve piglets per treatment (1 piglet per litter) were euthanized on day 18 to collect tissues to measure tumor necrosis factor-\u03b1, interleukin-8 (IL-8), malondialdehyde, protein carbonyl, IgA, histomorphology, crypt cell proliferation rate, and microbiota in the jejunum and colon. Data were analyzed using the MIXED procedure of SAS, and the mortality was analyzed using the GLIMMIX procedure of SAS. There was no difference in sow BW, parity, and litter size between treatments on day 0 of lactation. Sows fed LPL had increased (P &amp;lt; 0.05) litter BW gain (53.9 vs. 59.4 kg) and decreased piglet mortality (13.9% vs. 10.6%) on day 18 of lactation. Sows fed LPL had increased (P &amp;lt; 0.05) omega-6:omega-3 (22.1 vs. 23.7) and unsaturated:saturated (1.4 vs. 1.6) fatty acids ratios with increased oleic acid (29.1% vs. 31.4%) and tended to have increased (P = 0.092) IgG (1.14 vs. 1.94 g\/L) and linoleic acid (17.7% vs. 18.7%) in the milk on day 18 of lactation. Piglets from sows fed LPL had increased (P &amp;lt; 0.05) IL-8 (184 vs. 245 pg\/mg) and crypt cell proliferation rate (39.4% vs. 40.9%) and tended to have increased (P = 0.095) Firmicutes:Bacteroidetes ratio (1.0 vs. 3.5) in the jejunum. In conclusion, sows fed with LPL had milk with increased IgG, oleic acids, and linoleic acids without changes in BW and backfat during lactation. These changes could contribute to improved survivability and intestinal health of piglets by increasing IL-8 concentration, enhancing balance among gut-associated microbiome, and increasing enterocyte proliferation in the jejunum.<\/jats:p>","DOI":"10.1093\/jas\/skaa227","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T06:26:52Z","timestamp":1595053612000},"source":"Crossref","is-referenced-by-count":38,"title":["Supplemental effects of dietary lysophospholipids in lactation diets on sow performance, milk composition, gut health, and gut-associated microbiome of offspring"],"prefix":"10.1093","volume":"98","author":[{"given":"Ki Beom","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry M","family":"Purvis","sequence":"additional","affiliation":[{"name":"N.G. Purvis Farm Inc., Robbins, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,18]]},"reference":[{"key":"2020083110421097200_CIT0001","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.3390\/ijms20071630","article-title":"Characterization of microbiota associated with digesta and mucosa in different regions of gastrointestinal tract of nursery pigs","volume":"20","author":"Adhikari","year":"2019","journal-title":"Int. J. Mol. Sci"},{"key":"2020083110421097200_CIT0002","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0261-5614(03)00083-9","article-title":"Linoleic acid, but not oleic acid, upregulates the production of interleukin-8 by human intestinal smooth muscle cells isolated from patients with Crohn\u2019s disease","volume":"22","author":"Alzoghaibi","year":"2003","journal-title":"Clin. Nutr"},{"key":"2020083110421097200_CIT0003","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.3389\/fimmu.2018.01270","article-title":"Cytokine tuning of intestinal epithelial function","volume":"9","author":"Andrews","year":"2018","journal-title":"Front. Immunol"},{"key":"2020083110421097200_CIT0004","volume-title":"Official methods of analysis of AOAC International","author":"AOAC","year":"2019","edition":"21"},{"key":"2020083110421097200_CIT0005","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/ajcn\/70.6.1096","article-title":"Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract","volume":"70","author":"Armand","year":"1999","journal-title":"Am. J. Clin. Nutr"},{"key":"2020083110421097200_CIT0006","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbalip.2013.12.015","article-title":"Characterization of a lysophospholipid acyltransferase involved in membrane remodeling in Candida albicans","volume":"1841","author":"Ayyash","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"issue":"Pt 3","key":"2020083110421097200_CIT0007","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1042\/bj2880763","article-title":"The activities of acyl-CoA:1-acyl-lysophospholipid acyltransferase(s) in human platelets","volume":"288","author":"Bakken","year":"1992","journal-title":"Biochem. J"},{"key":"2020083110421097200_CIT0083","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1021\/bi00122a022","article-title":"Association and metabolism of exogenously-derived lysophosphatidylcholine by cultured mammalian cells: kinetics and mechanisms","volume":"31","author":"Besterman","year":"1992","journal-title":"Biochemistry"},{"key":"2020083110421097200_CIT0008","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1017\/S1751731111000772","article-title":"Oxidative stress status of highly prolific sows during gestation and lactation","volume":"5","author":"Berchieri-Ronchi","year":"2011","journal-title":"Animal"},{"key":"2020083110421097200_CIT0009","first-page":"157","article-title":"The transfer of immunoglobins IgG, IgA and IgM from serum to colostrum and milk in the sow","volume":"24","author":"Bourne","year":"1973","journal-title":"Immunology"},{"key":"2020083110421097200_CIT0010","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.3945\/jn.111.142562","article-title":"Oxidation of dietary stearic, oleic, and linoleic acids in growing pigs follows a biphasic pattern","volume":"141","author":"Bruininx","year":"2011","journal-title":"J. Nutr"},{"key":"2020083110421097200_CIT0011","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10557-008-6132-9","article-title":"Phospholipase A2 biochemistry","volume":"23","author":"Burke","year":"2009","journal-title":"Cardiovasc. Drugs Ther"},{"key":"2020083110421097200_CIT0012","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aninu.2017.09.005","article-title":"Impacts of energy feeds and supplemental protease on growth performance, nutrient digestibility, and gut health of pigs from 18 to 45 kg body weight","volume":"3","author":"Chen","year":"2017","journal-title":"Anim. Nutr"},{"key":"2020083110421097200_CIT0013","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/nu2020116","article-title":"Dietary phospholipids and intestinal cholesterol absorption","volume":"2","author":"Cohn","year":"2010","journal-title":"Nutrients"},{"key":"2020083110421097200_CIT0014","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/MOL.0b013e3282ffaf96","article-title":"Dietary phospholipids, hepatic lipid metabolism and cardiovascular disease","volume":"19","author":"Cohn","year":"2008","journal-title":"Curr. Opin. Lipidol"},{"key":"2020083110421097200_CIT0015","doi-asserted-by":"crossref","first-page":"1212S","DOI":"10.1093\/ajcn\/79.6.1212S","article-title":"Conjugated linoleic acid pork research","volume":"79","author":"Dugan","year":"2004","journal-title":"Am. J. Clin. Nutr"},{"key":"2020083110421097200_CIT0016","doi-asserted-by":"crossref","first-page":"594","DOI":"10.2527\/2003.813594x","article-title":"The importance of a high feed intake during lactation of primiparous sows nursing large litters","volume":"81","author":"Eissen","year":"2003","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0017","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.3390\/ijms12042408","article-title":"Nutritional deficiencies and phospholipid metabolism","volume":"12","author":"Gimenez","year":"2011","journal-title":"Int. J. Mol. Sci"},{"key":"2020083110421097200_CIT0018","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S1388-1981(02)00152-X","article-title":"Lysophospholipids and their G protein-coupled receptors in inflammation and immunity","volume":"1582","author":"Gr\u00e4ler","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"2020083110421097200_CIT0019","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.plipres.2009.12.002","article-title":"The key roles of elongases and desaturases in mammalian fatty acid metabolism: insights from transgenic mice","volume":"49","author":"Guillou","year":"2010","journal-title":"Prog. Lipid Res"},{"key":"2020083110421097200_CIT0020","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1093\/jas\/skz146","article-title":"Lowering dietary cation-anion difference increases sow blood and milk calcium concentrations","volume":"97","author":"Guo","year":"2019","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0021","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.2527\/jas.2015-8973","article-title":"Temporary confinement of loose-housed hyperprolific sows reduces piglet mortality","volume":"93","author":"Hales","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0022","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/jn\/132.7.2019","article-title":"Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid","volume":"132","author":"Hontecillas","year":"2002","journal-title":"J. Nutr"},{"key":"2020083110421097200_CIT0023","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2460\/ajvr.2003.64.463","article-title":"Clinical characteristics, prevalence, influence on sow performance, and assessment of sow-related risk factors for granulomatous mastitis in sows","volume":"64","author":"Hult\u00e9n","year":"2003","journal-title":"Am. J. Vet. Res"},{"key":"2020083110421097200_CIT0024","doi-asserted-by":"crossref","first-page":"442","DOI":"10.3390\/nu3040442","article-title":"Perspectives on immunoglobulins in colostrum and milk","volume":"3","author":"Hurley","year":"2011","journal-title":"Nutrients"},{"key":"2020083110421097200_CIT0025","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1093\/carcin\/bgq131","article-title":"Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer","volume":"31","author":"Igal","year":"2010","journal-title":"Carcinogenesis"},{"key":"2020083110421097200_CIT0026","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.3382\/ps\/pev181","article-title":"Interaction between fat type and lysolecithin supplementation in broiler feeds","volume":"94","author":"Jansen","year":"2015","journal-title":"Poult. Sci"},{"key":"2020083110421097200_CIT0028","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1016\/j.bbamem.2007.05.011","article-title":"The gramicidin ion channel: a model membrane protein","volume":"1768","author":"Kelkar","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"2020083110421097200_CIT0029","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1194\/jlr.M087056","article-title":"Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis","volume":"59","author":"Kennelly","year":"2018","journal-title":"J. Lipid Res"},{"key":"2020083110421097200_CIT0030","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.2527\/jas.2014-8713","article-title":"The association between immunoglobulin G in sow colostrum and piglet plasma","volume":"93","author":"Kielland","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0031","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.2527\/2001.79102659x","article-title":"The regression of unsuckled mammary glands during lactation in sows: the influence of lactation stage, dietary nutrients, and litter size","volume":"79","author":"Kim","year":"2001","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0032","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.2527\/2001.7982179x","article-title":"Nutrient mobilization from body tissues as influenced by litter size in lactating sows","volume":"79","author":"Kim","year":"2001","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0033","doi-asserted-by":"crossref","first-page":"E123","DOI":"10.2527\/jas.2008-1452","article-title":"Ideal amino acid balance for sows during gestation and lactation","volume":"87","author":"Kim","year":"2009","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0034","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.2527\/1999.77123316x","article-title":"Mammary gland growth as influenced by litter size in lactating sows: impact on lysine requirement","volume":"77","author":"Kim","year":"1999","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/2049-1891-4-26","article-title":"Improving efficiency of sow productivity: nutrition and health","volume":"4","author":"Kim","year":"2013","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020083110421097200_CIT0036","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1017\/S175173111900260X","article-title":"Effect of litter size, milk replacer and housing on production results of hyper-prolific sows","volume":"14","author":"Kobek-Kjeldager","year":"2020","journal-title":"Animal"},{"key":"2020083110421097200_CIT0037","doi-asserted-by":"crossref","first-page":"e0215255","DOI":"10.1371\/journal.pone.0215255","article-title":"Role of lysophosphatidic acid in proliferation and differentiation of intestinal epithelial cells","volume":"14","author":"Konno","year":"2019","journal-title":"PLoS One"},{"key":"2020083110421097200_CIT0039","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1128\/IAI.66.5.2200-2206.1998","article-title":"Production of proinflammatory cytokines and inflammatory mediators in human intestinal epithelial cells after invasion by Trichinella spiralis","volume":"66","author":"Li","year":"1998","journal-title":"Infect. Immun"},{"key":"2020083110421097200_CIT0040","doi-asserted-by":"crossref","first-page":"7117","DOI":"10.1074\/jbc.M112.415729","article-title":"Oleic acid stimulates complete oxidation of fatty acids through protein kinase A-dependent activation of SIRT1-PGC1\u03b1 complex","volume":"288","author":"Lim","year":"2013","journal-title":"J. Biol. Chem"},{"key":"2020083110421097200_CIT0041","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.jnutbio.2010.09.002","article-title":"Dietary conjugated linoleic acid alters long chain polyunsaturated fatty acid metabolism in brain and liver of neonatal pigs","volume":"22","author":"Lin","year":"2011","journal-title":"J. Nutr. Biochem"},{"key":"2020083110421097200_CIT0042","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1085\/jgp.104.4.645","article-title":"Lysophospholipids modulate channel function by altering the mechanical properties of lipid bilayers","volume":"104","author":"Lundbaek","year":"1994","journal-title":"J. Gen. Physiol"},{"key":"2020083110421097200_CIT0043","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1098\/rsif.2009.0443","article-title":"Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes","volume":"7","author":"Lundbaek","year":"2010","journal-title":"J. R. Soc. Interface"},{"key":"2020083110421097200_CIT0044","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cis.2010.12.002","article-title":"The role of bile salts in digestion","volume":"165","author":"Maldonado-Valderrama","year":"2011","journal-title":"Adv. Colloid Interface Sci"},{"key":"2020083110421097200_CIT0045","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/1471-2180-9-123","article-title":"The Firmicutes\/Bacteroidetes ratio of the human microbiota changes with age","volume":"9","author":"Mariat","year":"2009","journal-title":"BMC Microbiol"},{"key":"2020083110421097200_CIT0046","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S0022-2275(20)37146-7","article-title":"Intestinal absorption of essential fatty acids under physiological and essential fatty acid-deficient conditions","volume":"38","author":"Minich","year":"1997","journal-title":"J. Lipid Res"},{"key":"2020083110421097200_CIT0047","first-page":"142","article-title":"Increased proliferative response of lymphocytes from intestinal lymph during long chain fatty acid absorption","volume":"78","author":"Miura","year":"1993","journal-title":"Immunology"},{"key":"2020083110421097200_CIT0048","doi-asserted-by":"crossref","first-page":"9938","DOI":"10.1038\/srep09938","article-title":"Dynamic distribution of the gut microbiota and the relationship with apparent crude fiber digestibility and growth stages in pigs","volume":"5","author":"Niu","year":"2015","journal-title":"Sci. Rep"},{"key":"2020083110421097200_CIT0084","article-title":"Nutrient requirements of swine","author":"NRC","year":"2012","edition":"11"},{"key":"2020083110421097200_CIT0049","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/rda.13463","article-title":"The challenge of large litters on the immune system of the sow and the piglets","volume":"54","author":"Oliviero","year":"2019","journal-title":"Reprod. Domest. Anim"},{"key":"2020083110421097200_CIT0050","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/sj.bjc.6605588","article-title":"Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression","volume":"102","author":"Panupinthu","year":"2010","journal-title":"Br. J. Cancer"},{"key":"2020083110421097200_CIT0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1042\/bj1400503","article-title":"The mechanism of intestinal absorption of phosphatidylcholine in rats","volume":"140","author":"Parthasarathy","year":"1974","journal-title":"Biochem J"},{"key":"2020083110421097200_CIT0051","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.3390\/nu11092064","article-title":"Dietary fatty acids and host-microbial crosstalk in neonatal enteric infection","volume":"11","author":"Quin","year":"2019","journal-title":"Nutrients"},{"key":"2020083110421097200_CIT0052","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/jcb.20094","article-title":"G protein mediated signaling pathways in lysophospholipid induced cell proliferation and survival","volume":"92","author":"Radeff-Huang","year":"2004","journal-title":"J. Cell. Biochem"},{"key":"2020083110421097200_CIT0053","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cis.2008.06.001","article-title":"Lipases at interfaces: a review","volume":"147\u2013148","author":"Reis","year":"2009","journal-title":"Adv. Colloid Interface Sci"},{"key":"2020083110421097200_CIT0054","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1186\/1751-0147-44-S1-S105","article-title":"Uptake of colostral immunoglobulins by the compromised newborn farm animal","volume":"44","author":"Sangild","year":"2003","journal-title":"Acta Vet. Scand"},{"key":"2020083110421097200_CIT0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2049-1891-5-9","article-title":"Emerging evidence of the physiological role of hypoxia in mammary development and lactation","volume":"5","author":"Shao","year":"2014","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020083110421097200_CIT0056","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/bbb.1937","article-title":"Latest advances in degumming feedstock oils for large-scale biodiesel production","volume":"13","author":"Sharma","year":"2019","journal-title":"Biofuels Bioprod. Biorefining"},{"key":"2020083110421097200_CIT0057","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1513\/pats.201201-005AW","article-title":"Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis","volume":"9","author":"Shea","year":"2012","journal-title":"Proc. Am. Thorac. Soc"},{"key":"2020083110421097200_CIT0058","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2527\/jas.2010-3642","article-title":"Effects of supplementing Saccharomyces cerevisiae fermentation product in sow diets on performance of sows and nursing piglets","volume":"89","author":"Shen","year":"2011","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0059","doi-asserted-by":"crossref","first-page":"5530","DOI":"10.2527\/jas.2014-7830","article-title":"Effect of feed grade L-methionine on growth performance and gut health in nursery pigs compared with conventional DL-methionine","volume":"92","author":"Shen","year":"2014","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0060","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/asj.12241","article-title":"Impact of fat and selected profiles of fatty acids contained in the colostrum and milk of sows of native breeds on piglet rearing","volume":"86","author":"Skrzypczak","year":"2015","journal-title":"Anim. Sci. J"},{"key":"2020083110421097200_CIT0061","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fimmu.2018.00220","article-title":"Preterm life in sterile conditions: a study on preterm, germ-free piglets","volume":"9","author":"Splichalova","year":"2018","journal-title":"Front. Immunol"},{"key":"2020083110421097200_CIT0062","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1017\/S1751731117000155","article-title":"Sows with high milk production had both a high feed intake and high body mobilization","volume":"11","author":"Strathe","year":"2017","journal-title":"Animal"},{"key":"2020083110421097200_CIT0063","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41385-018-0029-0","article-title":"Influence of gut microbiome on mucosal immune activation and SHIV viral transmission in naive macaques","volume":"11","author":"Sui","year":"2018","journal-title":"Mucosal Immunol"},{"key":"2020083110421097200_CIT0064","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/gut.26.4.369","article-title":"Lysophosphatidylcholine increases rat ileal permeability to macromolecules","volume":"26","author":"Tagesson","year":"1985","journal-title":"Gut"},{"key":"2020083110421097200_CIT0086","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/oxfordjournals.jbchem.a135060","article-title":"Quantitative studies on translocation and metabolic conversion of lysophosphatidylcholine incorporated into the membrane of intact human erythrocytes from the medium","volume":"97","author":"Tamura","year":"1985","journal-title":"J Biochem"},{"key":"2020083110421097200_CIT0065","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1046\/j.1440-1746.2001.02537.x","article-title":"Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids","volume":"16","author":"Tanaka","year":"2001","journal-title":"J. Gastroenterol. Hepatol"},{"key":"2020083110421097200_CIT0066","doi-asserted-by":"crossref","first-page":"270301","DOI":"10.1155\/2013\/270301","article-title":"Neonatal immune adaptation of the gut and its role during infections","volume":"2013","author":"Tourneur","year":"2013","journal-title":"Clin. Dev. Immunol"},{"key":"2020083110421097200_CIT0067","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0022-2275(20)35102-6","article-title":"Absorption and distribution of arachidonate in rats receiving lysophospholipids by oral route","volume":"34","author":"Viola","year":"1993","journal-title":"J. Lipid Res"},{"key":"2020083110421097200_CIT0068","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.anifeedsci.2018.12.009","article-title":"Effects of dietary lysophospholipid complex supplementation on lactation performance, and nutrient digestibility in lactating sows","volume":"251","author":"Wang","year":"2019","journal-title":"Anim. Feed Sci. Technol"},{"key":"2020083110421097200_CIT0069","first-page":"1","article-title":"Energy metabolism in the intestinal crypt epithelial cells of piglets during the suckling period","volume":"8","author":"Wang","year":"2018","journal-title":"Sci. Rep"},{"key":"2020083110421097200_CIT0070","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1007\/BF02669968","article-title":"Phospholipid content of foods","volume":"60","author":"Weihrauch","year":"1983","journal-title":"J. Am. Oil Chem. Soc"},{"key":"2020083110421097200_CIT0087","doi-asserted-by":"crossref","first-page":"9147","DOI":"10.1074\/jbc.270.16.9147","article-title":"Uptake of exogenous sn-1-acyl-2-lyso-phosphatidylinositol into HeLa S3 cells. Reacylation on the cell surface and metabolism to glucosaminyl(acyl)phosphatidylinositol","volume":"270","author":"Wongkajornsilp","year":"1995","journal-title":"J Biol Chem"},{"key":"2020083110421097200_CIT0071","first-page":"31","article-title":"Immunoglobulin A: molecular mechanisms of function and role in immune defence BT - molecular and cellular mechanisms of antibody activity.","author":"Woof","year":"2013"},{"key":"2020083110421097200_CIT0072","first-page":"801","article-title":"Glycerophosphate\/acylglycerophosphate acyltransferases","volume":"3","author":"Yamashita","year":"2014","journal-title":"Biology (Basel)"},{"key":"2020083110421097200_CIT0073","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/2049-1891-3-43","article-title":"Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins, cytokines, fatty acid composition, and performance of lactating sows and suckling piglets","volume":"3","author":"Yao","year":"2012","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020083110421097200_CIT0074","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1093\/jn\/131.11.2943","article-title":"Fatty acids enhance GRO\/CINC-1 and interleukin-6 production in rat intestinal epithelial cells","volume":"131","author":"Yoshida","year":"2001","journal-title":"J. Nutr"},{"key":"2020083110421097200_CIT0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41387-018-0045-x","article-title":"Update on glycerol-3-phosphate acyltransferases: the roles in the development of insulin resistance","volume":"8","author":"Yu","year":"2018","journal-title":"Nutr Diabetes"},{"key":"2020083110421097200_CIT0076","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1042\/CBI20100706","article-title":"Lysophosphatidic acid (LPA) stimulates mouse mammary epithelial cell growth","volume":"35","author":"Yuh","year":"2011","journal-title":"Cell Biol. Int"},{"key":"2020083110421097200_CIT0077","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-018-0291-8","article-title":"Recent progress of porcine milk components and mammary gland function","volume":"9","author":"Zhang","year":"2018","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2020083110421097200_CIT0078","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.3382\/ps\/pew469","article-title":"Effect of diets with different energy and lysophospholipids levels on performance, nutrient metabolism, and body composition in broilers","volume":"96","author":"Zhao","year":"2017","journal-title":"Poult. Sci"},{"key":"2020083110421097200_CIT0079","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1017\/S1751731116002238","article-title":"Effect of lysophospholipids in diets differing in fat contents on growth performance, nutrient digestibility, milk composition and litter performance of lactating sows","volume":"11","author":"Zhao","year":"2017","journal-title":"Animal"},{"key":"2020083110421097200_CIT0080","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1016\/j.bbalip.2016.11.015","article-title":"Biogenesis, transport and remodeling of lysophospholipids in Gram-negative bacteria","volume":"1862","author":"Zheng","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"2020083110421097200_CIT0081","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2527\/jam2016-0947","article-title":"Effects of dietary lysophospholipid complex on apparent ileal digestibility and growth performance in nursery pigs","volume":"94","author":"Zheng","year":"2016","journal-title":"J. Anim. Sci"},{"key":"2020083110421097200_CIT0082","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1002\/jcp.26199","article-title":"Glucose stimulates intestinal epithelial crypt proliferation by modulating cellular energy metabolism","volume":"233","author":"Zhou","year":"2018","journal-title":"J. Cell. Physiol"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skaa227\/33510750\/skaa227.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/98\/8\/skaa227\/33701495\/skaa227.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jas\/article-pdf\/98\/8\/skaa227\/33701495\/skaa227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T17:46:59Z","timestamp":1616694419000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skaa227\/5873431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,18]]},"references-count":85,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,7,18]]},"published-print":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/skaa227","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,8]]},"published":{"date-parts":[[2020,7,18]]},"article-number":"skaa227"}}