{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:05:30Z","timestamp":1785229530000,"version":"3.55.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T00:00:00Z","timestamp":1597017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100010318","name":"University of Manitoba","doi-asserted-by":"publisher","award":["46561"],"award-info":[{"award-number":["46561"]}],"id":[{"id":"10.13039\/100010318","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to evaluate the effects of supplementing broiler diets with a dietary protease on growth performance, digestive function, intestinal morphology, and meat quality as compared with feeding diets with or without an antibiotic growth promoter (AGP). A total of 240 1-day-old male chicks (Cobb 500, 48.3 \u00b1 3.3 g) were distributed to three treatments with eight replicates (10 birds per replicate). Three treatments were: 1) corn\u2013soybean meal basal diets (CTRL), 2) basal diets with 0.003% avilamycin (AB), and 3) basal diets with 0.0125% protease (PRT). The diets were provided as mash form, and birds were fed ad libitum during the whole experimental period. On day 45, birds were euthanized, and tissue and digesta samples were collected. On day 46, the remaining birds were processed in a commercial slaughterhouse, and breast muscle samples were collected. Despite a trend for a decreased feed conversion ratio (FCR) in the AB group during the whole phase (P = 0.071), no significant differences in growth performance parameters and relative weights of organs were observed (P &amp;gt; 0.05) among the groups. The AB and PRT groups showed significantly greater apparent ileal digestibility of amino acids (AA) compared with the CTRL group (P &amp;lt; 0.05). The PRT group significantly improved the morphology of duodenum and jejunum (P &amp;lt; 0.05). No differences were detected for meat quality, white striping, and woody breast among the groups (P &amp;gt; 0.05). For the gene expressions, the AB group showed a greater level of B0-system neutral amino acid co-transporter 1 and excitatory amino acid transporter 1 mRNA abundance compared with PRT group, while a significantly lesser level of cationic amino acid transporter 1 mRNA abundance was observed in the AB group compared with CTRL group (P &amp;lt; 0.05). The PRT group had a lesser level of peptide transporter 1 mRNA abundance in the jejunum than the CTRL group (P &amp;lt; 0.05). The highest mRNA abundances of zonula occludens-1 and cadherin 1 were observed in the CTRL group (P &amp;lt; 0.05). In conclusion, supplementation of avilamycin tended to reduce FCR and significantly improved AA utilization, and supplementation of dietary protease significantly enhanced intestinal morphology and AA utilization in broilers. In that respect, exogenous protease use appears to be an interesting tool to be considered in AGP reduction strategies.<\/jats:p>","DOI":"10.1093\/jas\/skaa254","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T14:57:12Z","timestamp":1597071432000},"source":"Crossref","is-referenced-by-count":26,"title":["Effects of antibiotic growth promoter and dietary protease on growth performance, apparent ileal digestibility, intestinal morphology, meat quality, and intestinal gene expression in broiler chickens: a comparison"],"prefix":"10.1093","volume":"98","author":[{"given":"Peng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janghan","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongwu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Mogire","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangxi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Lahaye","sequence":"additional","affiliation":[{"name":"Jefo Nutrition Inc., Saint-Hyacinthe, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Adewole","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Aquaculture, Dalhousie University, Truro, NS, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argenis","family":"Rodas-Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengbo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Manitoba, Winnipeg, MB, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,10]]},"reference":[{"key":"2020090314221902400_CIT0001","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.3382\/ps.2011-01482","article-title":"Effects of a monocomponent protease on performance and protein utilization in 7- to 22-day-old broiler chickens","volume":"90","author":"Angel","year":"2011","journal-title":"Poult. 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