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Greater losses in twin lambs (\u226530%) compared with singletons (\u226510%) are attributed primarily to lower birth weight and increased risk of intrapartum hypoxia, leading to impairment of thermoregulation, neuromotor activity, and maternal bonding behavior. Previous intensive studies demonstrated that supplementing pregnant ewes with melatonin reduced the adverse effects of fetal growth restriction and perinatal hypoxia on the neonatal brain via increased umbilical blood flow, placental efficiency, and antioxidant actions. The current study examined the effects of supplementing pregnant ewes with melatonin on lamb survival, birth weight, and behavior under intensive conditions. From gestational day (gD) 80 until parturition, pregnant singleton and twin-bearing ewes were supplemented with melatonin via a 2-mg capsule fed daily (Mel-FED, n = 61) or 18 mg subcutaneous implant (Regulin), with one implant administered at gD80 and another at gD125 (Mel-IMP, n = 60). Control ewes received no supplementation (CTL, n = 60). Ewes and lambs were monitored via video throughout parturition. Postpartum measures were taken from lambs at 4 and 24 h (live weight [LW], rectal temperature, serum immunoglobulin G, and latency to stand and suck after birth) and LW at 72 h, 7 d, marking (49.7 \u00b1 0.2 d), and weaning (124.2 \u00b1 0.8 d). Chi-square analysis was used to compare lamb survival between treatment groups. There were no treatment effects on singleton lamb survival. Melatonin supplementation tended to increase the proportion of twin lambs surviving from birth to weaning (Mel-FED = 85.5%; Mel-IMP = 85.9%; CTL = 72.9%; each P &amp;lt; 0.1). Survival of first-born twins did not differ between treatment (each ~90%, P = 0.745) but within second-born twins, survival of Mel-FED was greater than CTL (81.6 vs. 57.1%, P = 0.023), and Mel-IMP (78.1%) tended to be greater than CTL (P = 0.068). Similarly, in second-born twins exposed to prolonged parturition (\u2265 90 min), survival of lambs from Mel-FED ewes was greater than CTL (86.7% vs. 42.9%, P = 0.032), while Mel-IMP was intermediate (66.7%). These data suggest that the neuroprotective actions of melatonin may improve twin lamb survival by increasing tolerance of prolonged parturition and provide a sound basis for continued testing in extensively managed sheep flocks.<\/jats:p>","DOI":"10.1093\/jas\/skaa372","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T06:17:53Z","timestamp":1605680273000},"source":"Crossref","is-referenced-by-count":21,"title":["Supplementing Merino ewes with melatonin during the last half of pregnancy improves tolerance of prolonged parturition and survival of second-born twin lambs"],"prefix":"10.1093","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7287-8248","authenticated-orcid":false,"given":"Tom","family":"Flinn","sequence":"first","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niki L","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6267-6562","authenticated-orcid":false,"given":"Alyce M","family":"Swinbourne","sequence":"additional","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn L","family":"Gatford","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia"},{"name":"Adelaide Medical School, The University of Adelaide, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice C","family":"Weaver","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley A","family":"McGrice","sequence":"additional","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Kelly","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon K","family":"Walker","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L","family":"Kind","sequence":"additional","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"},{"name":"Robinson Research Institute, The University of Adelaide, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O","family":"Kleemann","sequence":"additional","affiliation":[{"name":"Turretfield Research Centre, South Australian Research and Development Institute, Rosedale, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H E J","family":"van Wettere","sequence":"additional","affiliation":[{"name":"Davies Livestock Research Centre, School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"2020122812494131000_CIT0001","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1071\/AR9620082","article-title":"Temperature regulation in the new-born lamb. 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