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The objective of this experiment was to evaluate the effects of the maternal supplementation with an enriched source of monounsaturated FA (MUFA) or an enriched source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during the first third of gestation on productive performance on ewes and offspring, and hypothalamic neuropeptides on offspring. Seventy-nine post-weaning lambs, born of sheep supplemented in the first third of gestation with 1.61% Ca salts rich with MUFA or EPA+DHA (dam supplementation, DS), were distributed in a 2\u00d72 factorial arrangement of treatments to finishing diets containing 1.48% of Ca salts of MUFA or EPA+DHA (lamb supplementation, LS). The finishing period of the offspring lasted for 56 d. During the finishing period dry matter intake (DMI, daily) and body weight (BW) were recorded. Plasma was collected for metabolites analysis. Twenty-four lambs were slaughtered, and hypothalamus was collected for mRNA expression of hormone receptors, neuropeptides, and lipid transport genes. The data were analyzed with a mixed model in SAS (9.4) using repeated measurements, when needed. There was a DS\u00d7LS interaction for BW (P = 0.10) where LS with EPA+DHA born from DS with MUFA were heavier than the other 3 treatments. Lambs born from DS with MUFA have a greater DMI (P &amp;lt; 0.01) than the offspring born from DS with EPA+DHA. Lambs born from MUFA supplemented dams had a greater (P \u2264 0.05) hypothalamus mRNA expression for cocaine and amphetamine regulated transcript, growth hormone receptor, metastasis suppressor 1, leptin receptor, pro-opiomelanocortin, and Neuropeptide Y. These results indicate that growth depends not on the type of FA during the finishing phase but the interaction of different sources of FA ad different stages. Also, supplementation with FA during early pregnancy changes productive performance and neuropeptides\u2019 mRNA expression of lambs independently of the finishing diet.<\/jats:p>","DOI":"10.1093\/jas\/skab064","type":"journal-article","created":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T13:51:40Z","timestamp":1614520300000},"source":"Crossref","is-referenced-by-count":13,"title":["Effect of supplementation with different fatty acid profile to the dam in early gestation and to the offspring on the finishing diet on offspring growth and hypothalamus mRNA expression in sheep"],"prefix":"10.1093","volume":"99","author":[{"given":"Mario Francisco","family":"Oviedo-Ojeda","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC), Wooster, OH 44691, USA"},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria, San Luis Potos\u00ed 78175, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alejandro","family":"Roque-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC), Wooster, OH 44691, USA"},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria, San Luis Potos\u00ed 78175, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Whalin","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC), Wooster, OH 44691, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor Aar\u00f3n","family":"Lee-Rangel","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria, San Luis Potos\u00ed 78175, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-3037","authenticated-orcid":false,"given":"Alejandro Enrique","family":"Relling","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC), Wooster, OH 44691, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"2021042616450583000_CIT0001","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000054716","article-title":"Hypothalamic gene expression in sheep for cocaine- and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance","volume":"75","author":"Adam","year":"2002","journal-title":"Neuroendocrinology"},{"key":"2021042616450583000_CIT0002","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1095\/biolreprod.114.124636","article-title":"Elevated body weight gain during the juvenile period alters neuropeptide Y-gonadotropin-releasing hormone circuitry in prepubertal heifers","volume":"92","author":"Alves","year":"2015","journal-title":"Biol. 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