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Weaned pigs (n = 34, 6.88 \u00b1 1.03 kg body weight [BW]) were individually housed in disease containment rooms and randomly allotted to one of the three dietary treatments: nursery basal diet (CON) and two additional diets supplemented with 0.5 or 50 mg\/kg carbadox to the nursery basal diet (TRA or REC), respectively. The experiment lasted 18 d with 7 d before and 11 d after the first E. coli inoculation. The E. coli F18 inoculum was orally provided to all pigs with a dose of 1010 colony-forming unit (CFU)\/3 mL for three consecutive days. Fecal and blood samples were collected on day 0 before inoculation and days 2, 5, 8, and 11 postinoculation (PI) to test the percentage of \u03b2-hemolytic coliforms in total coliforms and complete blood cell count, respectively. Sixteen pigs were euthanized on day 5 PI, whereas the remaining pigs were euthanized at the end of the experiment to collect the jejunal and ileal mucosa and mesenteric lymph node for gene expression and bacterial translocation, respectively. Pigs in REC had greater (P &amp;lt; 0.05) final BW and lower (P &amp;lt; 0.05) overall frequency of diarrhea compared with pigs in the CON and TRA groups. Pigs in TRA had the lowest (P &amp;lt; 0.05) average daily gain and feed efficiency from day 0 to 5 PI, highest (P &amp;lt; 0.05) percentage of \u03b2-hemolytic coliforms in fecal samples on days 2 and 5 PI, and greatest (P &amp;lt; 0.05) bacterial colonies in mesenteric lymph nodes on day 11 PI compared with pigs in the CON and REC groups. Pigs in TRA had the greatest (P &amp;lt; 0.05) neutrophils on day 5 PI and higher (P &amp;lt; 0.05) white blood cell counts and lymphocytes than other groups on day 11 PI. Pigs in TRA had the greatest (P &amp;lt; 0.05) serum C-reactive protein on days 2 and 5 PI and serum tumor necrosis factor-\u03b1 on day 5 PI, compared with pigs in the CON and REC groups. Pigs fed REC had increased (P &amp;lt; 0.05) mRNA expression of zona occludens-1 (ZO-1) and occludin (OCDN) and reduced (P &amp;lt; 0.05) interleukin-1 beta (IL1B), interleukin-6 (IL6), and tumor necrosis factor-alpha (TNFA) in ileal mucosa on day 5 PI, compared with the CON, whereas TRA upregulated (P &amp;lt; 0.05) mRNA expression of IL1B, IL6, and cyclooxygenase-2 (COX2) in the ileal mucosa on day 11 PI, compared with the REC. In conclusion, trace amounts of antibiotic may exacerbate the detrimental effects of E. coli infection on pig performance by increasing diarrhea and systemic inflammation of weanling pigs.<\/jats:p>","DOI":"10.1093\/jas\/skab073","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T02:35:47Z","timestamp":1615430147000},"source":"Crossref","is-referenced-by-count":24,"title":["Trace amounts of antibiotic exacerbated diarrhea and systemic\n                    inflammation of weaned pigs infected with a pathogenic <i>Escherichia\n                        coli<\/i>"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-6047","authenticated-orcid":false,"given":"Kwangwook","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Jinno","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Kovanda","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunde","family":"Li","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minho","family":"Song","sequence":"additional","affiliation":[{"name":"Division of Animal and Dairy Science, Chungnam National University, Daejeon 34134, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,6]]},"reference":[{"key":"2022032516084341300_CIT0001","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/2049-1891-4-52","article-title":"Escherichia\n                            coli challenge and one type of smectite alter intestinal\n                        barrier of pigs","volume":"4","author":"Almeida","year":"2013","journal-title":"J. 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