{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:21:56Z","timestamp":1788222116642,"version":"build-2803163510"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Apoio ao Ensino, Pesquisa e Extens\u00e3o"},{"DOI":"10.13039\/501100007374","name":"Universidade Federal de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011647","name":"Universidade Federal de Lavras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011647","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Embrapa Gado de Leite"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to identify possible effects of different vaccination strategies (concomitantly or not) against brucellosis and clostridia on intake, performance, feeding behavior, blood parameters, and immune responses of dairy heifers calves. Fifty heifers calves were enrolled [38 Gyr (Zebu, Bos taurus indicus) and 12 5\/8 Holstein \u00d7 Gyr]. At 120 d of age, animals were randomly distributed among 3 groups: B (n = 18), vaccinated against brucellosis; C (n = 14), vaccinated against clostridia and CB (n = 18), vaccinated concomitantly for both. Rectal and thermographic temperatures were evaluated on days \u22121, 0, 1, 2, 3, 5, 7,10, 14, and 28 relatives to the vaccination day. Feed and water intake, body weight (BW), and feeding behavior were monitored daily by an electronic feeding system. Blood was sampled on days 0, 3, 7, 14, and 28, relative to the vaccination day for determination of glucose and \u03b2 -hydroxybutyrate (BHBA) concentrations. Blood sampled on day 0 (prevaccination) and on days 28 and 42 were used to evaluate the immune response against Brucella abortus and clostridia. There was an increase in rectal temperature between the first and the third day postvaccination in the 3 groups. The thermography revealed an increase of local temperature for 7 d on groups B and CB. Group C had increased local temperature for a longer period, lasting for up to 14 d. Dry mater intake was reduced for groups B and CB, but no alteration was observed for group C. No alterations regarding initial BW, final BW, average daily weight gain, and feed efficiency were observed. No differences were observed for the 3 vaccination groups for blood parameters throughout the evaluation period. The concomitant vaccination against brucellosis and clostridia led to lower neutralizing antibody titers against epsilon toxin of Clostridium perfringens and botulinum toxin type C of C. botulinum (C &amp;gt; CB &amp;gt; B). When cellular proliferation assay and serological tests to B. abortus were evaluated, no differences were observed between groups B and CB. The present results indicate that the concomitant vaccination against brucellosis and clostridia has no relevant impact on the intake, performance, and feeding behavior of dairy calves. However, the concomitant vaccination of vaccines against these 2 pathogens impacts animal immunity against clostridial infections.<\/jats:p>","DOI":"10.1093\/jas\/skab107","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T21:28:14Z","timestamp":1617744494000},"source":"Crossref","is-referenced-by-count":6,"title":["Effects of vaccination against brucellosis and clostridia on the intake, performance, feeding behavior, blood parameters, and immune responses of dairy heifers calves"],"prefix":"10.1093","volume":"99","author":[{"given":"Hilton C","family":"Diniz Neto","sequence":"first","affiliation":[{"name":"Departamento de Zootecnia, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 30161-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara C","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Departamento de Zootecnia, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais 30161-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana M","family":"Campos","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria \u2013 Embrapa Gado de Leite, Juiz de Fora, Minas Gerais, 36038-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey P","family":"Lage","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Preventiva, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30161-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo O S","family":"Silva","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Preventiva, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30161-970, 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Pesquisa Agropecu\u00e1ria \u2013 Embrapa Gado de Leite, Juiz de Fora, Minas Gerais, 36038-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gustavo R","family":"Pereira","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria \u2013 Embrapa Gado de Leite, Juiz de Fora, Minas Gerais, 36038-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry R","family":"Tomich","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria \u2013 Embrapa Gado de Leite, Juiz de Fora, Minas Gerais, 36038-330, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina P","family":"Ramos","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Veterin\u00e1ria Preventiva, Escola de Veterin\u00e1ria, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, 30161-970, 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