{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T10:44:08Z","timestamp":1772880248084,"version":"3.50.1"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T00:00:00Z","timestamp":1623283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008370","name":"National Pork Board","doi-asserted-by":"publisher","award":["17-153"],"award-info":[{"award-number":["17-153"]}],"id":[{"id":"10.13039\/100008370","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A marker indicative of the fertility potential of replacement gilts early in development would decrease culling rates in the sow herd, improve sow herd reproductive efficiency, and reduce production costs. The objective of this study was to determine if vaginal lipid profiles at 21 d postnatal (PN) could predict sow reproductive performance. Vaginal swabs of the anterior vagina were taken at 21 \u00b1 4 d PN from gilts born on a commercial sow production facility for lipidomic analysis. Animals were followed prospectively for 2 yr and assigned to reproductive performance categories based on the observation of estrus or piglets weaned per sow per year (PSY) across two farrowings. Lipids were extracted from cellular material collected with swabs taken from high fertility (HF; n = 28; \u226526 PSY) and infertile (IF; n = 34; no estrus, no pregnancy) animals, and multiple reaction monitoring profiling was used for lipidome analysis. The relative abundance of arachidonic acid (C20:4) and docosahexaenoic acid (C22:6) was lower (P &amp;lt; 0.05) in IF gilts than HF gilts, whereas the abundance of the free fatty acids such as cerotic (C26:0), ximenic (C26:1), and nonadecanoic (C19:0) acids was greater (P &amp;lt; 0.05) in IF gilts. Additionally, eicosapentaenoic acid (C20:5), a precursor of prostaglandins, was higher (P &amp;lt; 0.05) in IF gilts. The perspective of having a panel of lipids captured with vaginal swabs at weaning that can predict the reproductive efficiency of gilts shows promise and warrants future research in this area.<\/jats:p>","DOI":"10.1093\/jas\/skab189","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T15:59:12Z","timestamp":1623340752000},"source":"Crossref","is-referenced-by-count":9,"title":["Biomarkers predictive of long-term fertility found in vaginal lipidome of gilts at weaning"],"prefix":"10.1093","volume":"99","author":[{"given":"Kayla M","family":"Mills","sequence":"first","affiliation":[{"name":"Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina R","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Metabolite Profiling Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jebadiah G","family":"Stevens","sequence":"additional","affiliation":[{"name":"Ag Production Enterprises, Greensburg, IN 47240, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6223-8159","authenticated-orcid":false,"given":"Kara R","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8835-3550","authenticated-orcid":false,"given":"Theresa M","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Purdue University, West Lafayette, IN 47907, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,6,10]]},"reference":[{"key":"2021080817505191100_CIT0001","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1093\/jn\/123.10.1668","article-title":"Docosahexaenoic acid is transferred through maternal diet to milk and to tissues of natural milk-fed piglets","volume":"123","author":"Arbuckle","year":"1993","journal-title":"J. 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