{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:30:06Z","timestamp":1780468206399,"version":"3.54.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Phytobiotics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To assess the efficacy of bis-glycinate bound Zn, 36 crossbred wethers (34 \u00b1 2 kg) were sorted by body weight into three groups and stagger started on a Zn-deficient diet (18 mg Zn\/kg dry matter [DM]; 22.5% neutral detergent fiber [NDF]) for 45 d prior to a 15-d metabolism period (10 d adaptation and 5 d collection). On day 46, lambs were randomly assigned to dietary treatments (four lambs treatment\u22121group\u22121): no supplemental Zn (CON) or 15 mg supplemental Zn\/kg DM (ZINC) as Zn sulfate (ZS) or bis-glycinate (GLY; Plexomin Zn, Phytobiotics). Blood was collected from all lambs on days 1, 44, 56, and 61. Liver, jejunum, and longissimus dorsi samples were collected after euthanasia on day 61. Gene expression was determined via quantitative real-time polymerase chain reaction. Data were analyzed using ProcMixed of SAS (experimental unit = lamb; fixed effects = treatment, group, and breed) and contrast statements assessed the effects of supplemental Zn concentration (ZINC vs. CON) and source (GLY vs. ZS). After 15 d of Zn supplementation, plasma Zn concentrations were greater for ZINC vs. CON and GLY vs. ZS (P \u2264 0.01); tissue Zn concentrations were unaffected (P \u2265 0.27). Liver Cu concentrations were lesser for ZINC vs. CON (P = 0.03). Longissimus dorsi Mn concentrations were greater for ZINC vs. CON (P = 0.05) and tended to be lesser for GLY vs. ZS (P = 0.09). Digestibility of DM, organic matter (OM), and NDF was lesser for ZINC vs. CON (P \u2264 0.05); acid detergent fiber digestibility tended to be greater for GLY vs. ZS (P = 0.06). Nitrogen retention (g\/d) tended to be greater for GLY vs. ZS (P = 0.10), and N apparent absorption was lesser for ZINC vs. CON (P = 0.02). Zinc intake, fecal output, retention, and apparent absorption were greater for ZINC vs. CON (P \u2264 0.01). Apparent absorption of Zn was \u22125.1%, 12.8%, and 15.0% for CON, ZS, and GLY, respectively. Nitrogen and Zn retention and apparent absorption were not correlated for CON (P \u2265 0.14) but were positively correlated for ZINC (retention: P = 0.02, r = 0.52; apparent absorption: P &amp;lt; 0.01, r = 0.73). Intestinal expression of Zn transporter ZIP4 was lesser for ZINC vs. CON (P = 0.02). Liver expression of metallothionein-1 (MT1) tended to be greater for GLY vs. ZS (P = 0.07). Although Zn apparent absorption did not differ between sources (P = 0.71), differences in post-absorptive metabolism may be responsible for greater plasma Zn concentrations and liver MT1 expression for GLY-supplemented lambs, suggesting improved bioavailability of GLY relative to ZS.<\/jats:p>","DOI":"10.1093\/jas\/skab252","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T11:54:33Z","timestamp":1630065273000},"source":"Crossref","is-referenced-by-count":8,"title":["Effect of bis-glycinate bound zinc or zinc sulfate on zinc metabolism in growing lambs"],"prefix":"10.1093","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-2584","authenticated-orcid":false,"given":"Erin L","family":"Deters","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison J","family":"VanDerWal","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R","family":"VanValin","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubree M","family":"Beenken","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie J","family":"Heiderscheit","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine G","family":"Hochmuth","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trey D","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-4006","authenticated-orcid":false,"given":"Elizabeth M","family":"Messersmith","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi L","family":"McGill","sequence":"additional","affiliation":[{"name":"Vet Microbiology and Preventative Medicine, Iowa State University College of Veterinary Medicine, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie L","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University College of Agriculture and Life Sciences, Ames, IA 50011, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"2021091704135543900_CIT0001","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s12011-018-1448-1","article-title":"Effect of different sources of supplemental zinc on performance, nutrient digestibility, and antioxidant enzyme activities in lambs","volume":"189","author":"Alimohamady","year":"2019","journal-title":"Biol. 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