{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T07:15:44Z","timestamp":1760080544198,"version":"3.41.2"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To assess plasma trace mineral (TM) concentrations, the acute phase protein response, and behavior in response to a lipopolysaccharide (LPS) challenge, 96 Angus cross steers (average initial body weight [BW]: 285 \u00b1 14.4 kg) were sorted into two groups by BW (heavy and light; n = 48\/group), fitted with an ear-tag\u2013based accelerometer (CowManager SensOor; Agis, Harmelen, Netherlands), and stagger started 14 d apart. Consecutive day BW was recorded to start the 24-d trial (days \u22121 and 0). Dietary treatments began on day 0: common diet with either 30 (Zn30) or 100 (Zn100) mg supplemental Zn\/kg DM (ZnSO4). On day 17, steers received one of the following injection treatments intravenously to complete the 2 \u00d7 3 factorial: 1) SALINE (~2\u20133 mL of physiological saline), 2) LOWLPS: 0.25 \u00b5g LPS\/kg BW, or 3) HIGHLPS: 0.375 \u00b5g LPS\/kg BW. Blood, rectal temperature (RT), and BW were recorded on day 16 (\u221224 h relative to injection), and BW was used to assign injection treatment. Approximately 6, 24 (day 18), and 48 (day 19) h after treatment, BW, RT, and blood were collected, and final BW recorded on day 24. Data were analyzed in Proc Mixed of SAS with fixed effects of diet, injection, diet \u00d7 injection; for BW, RT, dry matter intake (DMI), plasma TM, and haptoglobin-repeated measures analysis were used to evaluate effects over time. Area under the curve analysis determined by GraphPad Prism was used for analysis of accelerometer data. Body weight was unaffected by diet or injection (P \u2265 0.16), but there was an injection \u00d7 time effect for DMI and RT (P &amp;lt; 0.05), where DMI decreased in both LPS treatments on day 16, but recovered by day 17, and RT was increased in LPS treatments 6 h post-injection. Steers receiving LPS spent less time highly active and eating than SALINE (P &amp;lt; 0.01). Steers in HIGHLPS spent lesser time ruminating, followed by LOWLPS and then SALINE (P &amp;lt; 0.001). An injection \u00d7 time effect (P &amp;lt; 0.001) for plasma Zn showed decreased concentrations within 6 h of injection and remained decreased through 24 h before recovering by 48 h. A tendency for a diet \u00d7 time effect (P = 0.06) on plasma Zn suggests plasma Zn repletion occurred at a greater rate in Zn100 compared to Zn30. These results suggest that increased supplemental Zn may alter the rate of recovery of Zn status from an acute inflammatory event. Additionally, ear-tag\u2013based accelerometers used in this study were effective at detecting sickness behavior in feedlot steers, and rumination may be more sensitive than other variables.<\/jats:p>","DOI":"10.1093\/jas\/skab278","type":"journal-article","created":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T07:24:09Z","timestamp":1633159449000},"source":"Crossref","is-referenced-by-count":3,"title":["Dietary zinc concentration and lipopolysaccharide injection affect circulating trace minerals, acute phase protein response, and behavior as evaluated by an ear-tag\u2013based accelerometer in beef steers"],"prefix":"10.1093","volume":"99","author":[{"given":"Katherine R","family":"VanValin","sequence":"first","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remy N","family":"Carmichael-Wyatt","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0605-2584","authenticated-orcid":false,"given":"Erin L","family":"Deters","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-4006","authenticated-orcid":false,"given":"Elizabeth M","family":"Messersmith","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katie J","family":"Heiderscheit","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine G","family":"Hochmuth","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trey D","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua M","family":"Peschel","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Biosystems Engineering, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna K","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University, Ames, IA 50011, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"2021101914434230900_CIT0001","first-page":"167","article-title":"Bacterial lipopolysaccharides and innate immunity","volume":"7","author":"Alexander","year":"2001","journal-title":"J. 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