{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:36:27Z","timestamp":1785342987095,"version":"3.55.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NSERC Canadian Research Development"},{"DOI":"10.13039\/501100000094","name":"Ontario Ministry of Agriculture and Rural Affairs","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000094","id-type":"DOI","asserted-by":"crossref"}]},{"name":"University of Guelph Productions System Tier II Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunoglobulin (Ig) G and natural antibody (NAb) IgM are passively transferred to the neonatal calf through bovine colostrum. Maternal IgG provides pathogen- or vaccine-specific protection and comprises about 85% of colostral Ig. NAb-IgM is less abundant but provides broad and nonspecific reactivity, potentially contributing to protection against the dissemination of pathogens in the blood (septicemia) in a calf\u2019s first days of life. In the dairy and beef industries, failure of passive transfer (FPT) of colostral Ig (serum total protein [STP] &amp;lt;5.2\u00a0g\/dL) is still a common concern. The objectives of this study were to: (1) compare colostral IgG concentrations and NAb-IgM titers between dairy and beef cows; (2) assess the effect of beef breed on colostral IgG; (3) compare passive transfer of colostral Ig in dairy and beef calves; and (4) estimate the heritability of colostral IgG and NAb-IgM. Colostrum was collected from Holstein dairy (n = 282) and crossbred beef (n = 168) cows at the University of Guelph dairy and beef research centers. Colostral IgG was quantified by radial immunodiffusion and NAb-IgM was quantified by an enzyme-linked immunosorbent assay. In dairy (n = 308) and beef (n = 169) calves, STP was estimated by digital refractometry. Beef cows had significantly greater colostral IgG (146.5\u00a0\u00b1\u00a09.5 standard error of the mean [SEM] g\/L) than dairy cows (92.4\u00a0\u00b1\u00a05.2\u00a0g\/L, P &amp;lt;0.01). Beef cows with a higher proportion of Angus ancestry had significantly lower colostral IgG (125.5\u00a0\u00b1\u00a05.8\u00a0g\/L) than cows grouped as \u201cOther\u201d (142.5\u00a0\u00b1\u00a04.9\u00a0g\/L, P = 0.02). Using the FPT cutoff, 13% of dairy and 16% of beef calves had FPT; still, beef calves had a significantly larger proportion with excellent passive transfer (STP \u22656.2\u00a0g\/dL, P &amp;lt;0.01). The heritability of colostral IgG was 0.04 (\u00b10.14) in dairy and 0.14 (\u00b10.32) in beef. Colostral NAb-IgM titers in dairy (12.12\u00a0\u00b1\u00a00.22, log2 [reciprocal of titer]) and beef cows (12.03\u00a0\u00b1\u00a00.19) did not differ significantly (P = 0.71). The range of NAb-IgM titers was 9.18\u201314.60, equivalent to a 42-fold range in antibody concentration. The heritability of colostral NAb was 0.24 (\u00b10.16) in dairy and 0.11 (\u00b10.19) in beef cows. This study is the first to compare colostral NAb-IgM between dairy and beef cows. Based on the range in NAb-IgM titers and the heritability, selective breeding may improve colostrum quality and protection for neonatal calves in the early days of life.<\/jats:p>","DOI":"10.1093\/jas\/skac006","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T01:04:00Z","timestamp":1642035840000},"source":"Crossref","is-referenced-by-count":12,"title":["Concentration and heritability of immunoglobulin G and natural antibody immunoglobulin M in dairy and beef colostrum along with serum total protein in their calves"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-8567","authenticated-orcid":false,"given":"Tess E","family":"Altvater-Hughes","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas C","family":"Hodgins","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauraine","family":"Wagter-Lesperance","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon C","family":"Beard","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon L","family":"Cartwright","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie A","family":"Mallard","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"issue":"4","key":"2022021617132920400_CIT0001","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00281-004-0182-2","article-title":"Inherent specificities in natural antibodies: a key to immune defense against pathogen invasion.","volume":"26","author":"Baumgarth","year":"2005","journal-title":"Springer Semin. 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