{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:40:47Z","timestamp":1785930047825,"version":"3.56.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1300300"],"award-info":[{"award-number":["2021YFD1300300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This experiment was conducted to investigate the effects of dietary supplementation of \u03b1-glycerol monolaurate (\u03b1-GML) on the growth performance, nutrient digestibility, serum profiles, intestinal morphology, and gut microbiota of weaned piglets. A total of 96 healthy 28-d-old (Duroc \u00d7 Landrace \u00d7 Yorkshire) weaned piglets with body weight of 8.34\u00a0\u00b1\u00a00.05\u00a0kg were randomly divided into 2 treatment groups with 6 replicate pens and 8 piglets per pen. The control group was fed a basal diet and the experimental group was fed the basal diet supplemented with 1,000\u00a0mg\/kg \u03b1-GML. The experiment lasted for 28 d. Dietary supplementation with \u03b1-GML had no effect on average daily gain, average daily feed intake, or gain to feed ratio in piglets (P &amp;gt; 0.05); however, it reduced (P &amp;lt; 0.05) diarrhea rate of piglets on days 15 to 28. The apparent total tract digestibility of dry matter (DM), crude protein (CP), ether extract (EE), and gross energy (GE) on day 14, and DM, organic matter, CP, EE, and GE on day 28 increased (P &amp;lt; 0.05) with \u03b1-GML supplementation. Moreover, higher (P &amp;lt; 0.05) glutathione peroxidase activity and interleukin-10 (IL-10) concentration, and lower (P &amp;lt; 0.05) malondialdehyde and tumor necrosis factor-\u03b1 concentrations were observed in piglets supplemented with \u03b1-GML compared with the control group on day 14. Compared with the control group, the villus height\/crypt depth in the duodenum and villus height in the jejunum and ileum were significantly greater (P &amp;lt; 0.05) in the \u03b1-GML group. Dietary \u03b1-GML supplementation significantly increased (P &amp;lt; 0.05) the relative abundance of Firmicutes, while decreasing (P &amp;lt; 0.05) Bacteroidota and Campilobacterota in the cecal contents; significantly increased (P &amp;lt; 0.05) the relative proportion of Lactobacillus and Blautia species, reduced (P &amp;lt; 0.05) Eubacterium_rectale_ATCC_33656, Campylobacter, and uncultured_bacterium_Alloprevotella species. Thus, dietary \u03b1-GML supplementation at 1,000\u00a0mg\/kg reduces diarrhea rate, improves intestinal morphology, nutrient digestibility, antioxidant capacity, and immune status, and ameliorates gut microbiota in weaned piglets.<\/jats:p>","DOI":"10.1093\/jas\/skac046","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T19:31:06Z","timestamp":1644953466000},"source":"Crossref","is-referenced-by-count":51,"title":["Effects of \u03b1-glycerol monolaurate on intestinal morphology, nutrient digestibility, serum profiles, and gut microbiota in weaned piglets"],"prefix":"10.1093","volume":"100","author":[{"given":"Longxian","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huakai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxi","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"issue":"1","key":"2022032516124628000_CIT0001","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/ani11010057","article-title":"Effect of dietary medium-chain alpha-monoglycerides on the growth performance, intestinal histomorphology, amino acid digestibility, and broiler chickens\u2019 blood biochemical parameters.","volume":"11","author":"Amer","year":"2020","journal-title":"Animals (Basel)"},{"key":"2022032516124628000_CIT0002","volume-title":"Official methods of analysis","author":"AOAC.","year":"2007","edition":"18"},{"key":"2022032516124628000_CIT0003","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/jas\/skx062","article-title":"Weaning disrupts intestinal antioxidant status, impairs intestinal barrier and mitochondrial function, and triggers mitophagy in piglets.","volume":"96","author":"Cao","year":"2018","journal-title":"J. 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