{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T10:41:56Z","timestamp":1781779316305,"version":"3.54.5"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T00:00:00Z","timestamp":1645747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MC048"],"award-info":[{"award-number":["ZR2021MC048"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Pig Industry Technology System","award":["SDAIT-08-04"],"award-info":[{"award-number":["SDAIT-08-04"]}]},{"name":"Shandong Province Pig Industry Technology System","award":["SDAIT-08-05"],"award-info":[{"award-number":["SDAIT-08-05"]}]},{"name":"Major Innovative Projects of Shandong Province","award":["2019JZZY020609"],"award-info":[{"award-number":["2019JZZY020609"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to investigate the effect of zearalenone (ZEA) exposure on follicular development in weaned gilts, and its mechanism based on the silent information regulator 1 (SIRT1)\/peroxisome proliferator-activated receptor-\u03b3 co-activator 1\u03b1 (PGC-1\u03b1) signaling pathway. A total of 32 healthy female weaned piglets (Landrace \u00d7 Yorkshire \u00d7 Duroc) with an average body weight of 12.39\u00a0\u00b1\u00a00.24\u00a0kg were randomly allotted to a basal diet supplemented with 0, 0.15, 1.5, or 3.0\u00a0mg\/kg ZEA for a 32-d feeding test. Blood and ovarian samples were obtained at the end of the experiment to determine serum toxin concentrations, ovarian histology, and the expressions of proliferating cell nuclear antigen (PCNA) and SIRT1\/PGC-1\u03b1 signaling pathway-related genes. Results showed that the vulva area, serum concentrations of ZEA, \u03b1-zearalenol and \u03b2-zearalenol, the thickness of the growing follicular layer, and the diameter of the largest growing follicles, as well as the expressions of SIRT1, PGC-1\u03b1, estrogen-related receptor \u03b1 (ERR\u03b1), ATP synthase subunit beta (ATP5B), and PCNA, increased linearly (P &amp;lt; 0.05) with increasing dietary ZEA, whereas the thickness of the primordial follicle layer decreased linearly (P &amp;lt; 0.05). Immunohistochemical analysis showed that the immunoreactive substances of SIRT1 and PGC-1\u03b1 in the ovaries enhanced with the increasing dietary ZEA (P &amp;lt; 0.05). In addition, the thickness of the growing follicular layer and the diameter of the largest growing follicle were positively correlated with relative mRNA and protein expressions of SIRT1, PGC-1\u03b1, ERR\u03b1, ATP5B, and PCNA (P &amp;lt; 0.05). However, the thickness of the primordial follicle layer was negatively correlated with the mRNA and protein expression of SIRT1, PGC-1\u03b1, ERR\u03b1, ATP5B, and PCNA (P &amp;lt; 0.05). Interestingly, the 1.5\u00a0mg\/kg ZEA treatment had highly hyperplastic follicles, whereas 3.0\u00a0mg\/kg ZEA resulted in a large number of follicular atresia, which indicated that low-dose ZEA exposure accelerated follicular proliferation, while high-dose ZEA promoted follicular atresia, although the critical value interval needs further confirmation. Results provide a theoretical basis for finding the therapeutic target of ZEA-induced reproductive disorders in weaned gilts.<\/jats:p>","DOI":"10.1093\/jas\/skac058","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T21:09:34Z","timestamp":1645823374000},"source":"Crossref","is-referenced-by-count":26,"title":["Zearalenone promotes follicle development through activating the SIRT1\/PGC-1\u03b1 signaling pathway in the ovaries of weaned gilts"],"prefix":"10.1093","volume":"100","author":[{"given":"Boyang","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2318-1954","authenticated-orcid":false,"given":"Libo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwei","family":"Jing","sequence":"additional","affiliation":[{"name":"Technical Department, Shandong Chinwhiz Co., Weifang, Shandong 262400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Feeding Microecology, Shandong Baolaililai Bioengineering Co., Ltd., Taian, Shandong 271001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiren","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences and Technology and Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian, Shandong 271018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"2022041010174567300_CIT0001","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1021\/acs.jafc.8b05838","article-title":"Insights into in vivo absolute oral bioavailability, biotransformation, and toxicokinetics of zearalenone, alpha-zearalenol, beta-zearalenol, zearalenone-14-glucoside, and zearalenone-14-sulfate in pigs.","volume":"67","author":"Catteuw","year":"2019","journal-title":"J. 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