{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T14:53:09Z","timestamp":1775832789400,"version":"3.50.1"},"reference-count":73,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The objective of this study was to evaluate whether oversupplying metabolizable protein (MP) during late gestation influences glucose and insulin concentrations, and insulin resistance (IR) in late gestation and early lactation. Crossbred Hereford, first-lactation heifers were individually fed diets to supply 133% (HMP, n = 11) or 100% (CON, n = 10) of their predicted MP requirements for 55 \u00b1 4 d (mean \u00b1 SD) prior to calving. All heifers received a common lactation ration formulated to meet postpartum requirements (103% MP and 126% ME). After feed was withheld for 12 h, cattle underwent an intravenous glucose tolerance test (IVGTT) on days \u22126.7 \u00b1 0.9 and 14.3 \u00b1 0.4 by infusing a 50% dextrose solution (1.36 g glucose\/kg BW0.75) through a jugular catheter with plasma collected at \u221210, 0 (immediately after infusion), 5, 10, 15, 20, 25, 30, 45, 60, 75, 90, and 120 min, respective to the infusion. Glucose and insulin concentrations were assessed. Insulin resistance indices (homeostasis model of insulin resistance [HOMA-IR], quantitative insulin sensitivity check index [QUICKI], revised quantitative insulin sensitivity check index [RQUICK], and RQUICKI incorporating serum beta-hydroxybutyrate concentrations [RQUICKIBHB]) were calculated from measurements of serum non-esterified fatty acids and beta-hydroxybutyrate and plasma glucose and insulin concentrations on days \u221234 \u00b1 4, \u221215 \u00b1 4, 7 \u00b1 1, 28 \u00b1 3, 70 \u00b1 3, and 112 \u00b1 3. Colostrum samples were collected within an hour of calving (prior to suckling) and analyzed for insulin concentration. Data were analyzed as a randomized block design using the PROC GLIMMIX of SAS, accounting for repeated measurements when necessary. Baseline (\u221210 min) plasma glucose and insulin concentrations were elevated (P \u2264 0.038) for HMP heifers during the antepartum IVGTT, but not (P \u2265 0.25) during the postpartum IVGTT. Plasma glucose and insulin concentrations throughout the antepartum or postpartum IVGTT did not differ (P \u2265 0.18) by prepartum treatment, nor did other glucose and insulin IVGTT parameters (i.e., max concentration and time to reach max concentration, nadir values, clearance rates and half-lives, area-under-the-curve, and insulin sensitivity index; P \u2265 0.20). Antepartum IVGTT IR indices indicated that HMP heifers were more (P \u2264 0.011) IR than their counterparts. Similarly, the prepartum HOMA-IR was greater (P = 0.033) for HMP heifers, suggesting increased IR. Postpartum IR indices did not (P \u2265 0.25) indicate that prepartum MP consumption impacted postpartum IR. Colostrum insulin concentration was increased (P = 0.004) by nearly 2-fold for HMP relative to CON heifers. These data demonstrate that prepartum MP overfeeding alters baseline glucose-insulin concentrations in late-pregnant beef heifers and increases colostrum insulin content without having carry-over effects on postpartum glucose-insulin concentrations and IR.<\/jats:p>","DOI":"10.1093\/jas\/skac101","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T17:12:35Z","timestamp":1648660355000},"source":"Crossref","is-referenced-by-count":5,"title":["Oversupplying metabolizable protein during late gestation to beef cattle does not influence ante- or postpartum glucose-insulin kinetics but does affect prepartum insulin resistance indices and colostrum insulin content"],"prefix":"10.1093","volume":"100","author":[{"given":"Koryn S","family":"Hare","sequence":"first","affiliation":[{"name":"Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-2130","authenticated-orcid":false,"given":"Gregory B","family":"Penner","sequence":"additional","affiliation":[{"name":"Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael A","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1741-7000","authenticated-orcid":false,"given":"Katharine M","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"2022051715041652100_CIT0001","first-page":"R947","article-title":"Effect of glucose supply on ovine uteroplacental glucose metabolism.","volume":"277","author":"Aldoretta","year":"1999","journal-title":"Am. 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Dairy Sci"},{"key":"2022051715041652100_CIT0007","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.2527\/1995.7392804x","article-title":"Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation.","volume":"73","author":"Bell","year":"1995","journal-title":"J. Anim. Sci"},{"key":"2022051715041652100_CIT0008","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1026336505343","article-title":"Adaptations of glucose metabolism during pregnancy and lactation.","volume":"2","author":"Bell","year":"1997","journal-title":"J. Mamm. Gland Biol. Neoplas."},{"key":"2022051715041652100_CIT0009","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1172\/JCI112886","article-title":"Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.","volume":"79","author":"Bergman","year":"1987","journal-title":"J. Clin. 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Dairy Sci"},{"key":"2022051715041652100_CIT0035","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/ani10030496","article-title":"The effect of feeding roughages of varying digestibility prepartum on energy status and metabolic profiles in beef cows around parturition.","volume":"10","author":"Jardstedt","year":"2020","journal-title":"Animals"},{"key":"2022051715041652100_CIT0036","doi-asserted-by":"crossref","first-page":"5606","DOI":"10.2527\/jas2017.1817","article-title":"Effect of dietary energy substrate and days on feed on apparent total tract digestibility, ruminal short-chain fatty acid absorption, acetate and glucose clearance, and insulin responsiveness in finishing feedlot cattle.","volume":"95","author":"Joy","year":"2017","journal-title":"J. Anim. Sci"},{"key":"2022051715041652100_CIT0037","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/B978-012396305-5\/50004-X","article-title":"Carbohydrate metabolism and its diseases.","volume-title":"Clinical biochemistry of domestic animals","author":"Kaneko","year":"1997","edition":"6"},{"key":"2022051715041652100_CIT0038","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1210\/jcem.85.7.6661","article-title":"Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans.","volume":"85","author":"Katz","year":"2000","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"2022051715041652100_CIT0039","first-page":"97","article-title":"Overfeeding dairy cattle during late-pregnancy alters hepatic PPAR\u0251-regulated pathways including hepatokines: impact on metabolism and peripheral insulin sensitivity.","volume":"8","author":"Khan","year":"2014","journal-title":"Gene Reg. Syst. Biol"},{"key":"2022051715041652100_CIT0040","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.3168\/jds.2016-12001","article-title":"Glucose requirements of an activated immune system in lactating Holstein cows.","volume":"100","author":"Kvidera","year":"2017","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0041","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/0026-0495(90)90172-9","article-title":"Insulin-mediated glucose uptake by individual tissues during sepsis.","volume":"39","author":"Lang","year":"1990","journal-title":"Metabolism"},{"key":"2022051715041652100_CIT0042","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4097\/kja.d.18.00242","article-title":"What is the proper way to apply the multiple comparison test?","volume":"71","author":"Lee","year":"2018","journal-title":"Korean J. Anesthesiol"},{"key":"2022051715041652100_CIT0043","doi-asserted-by":"crossref","first-page":"867","DOI":"10.3945\/ajcn.111.028431","article-title":"Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk.","volume":"95","author":"Ley","year":"2012","journal-title":"Am. J. Clin. Nutr"},{"key":"2022051715041652100_CIT0044","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.3168\/jds.S0022-0302(87)80285-0","article-title":"Periparturient changes in secretion and mammary uptake of insulin and in concentrations of insulin and insulin-like growth factors in milk of dairy cows.","volume":"70","author":"Malven","year":"1987","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0045","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00360-016-0969-1","article-title":"Insulin signaling and skeletal muscle atrophy and autophagy in transition dairy cows either overfed energy or fed a controlled energy diet prepartum.","volume":"186","author":"Mann","year":"2016","journal-title":"J. Comp. Physiol. B"},{"key":"2022051715041652100_CIT0046","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.3168\/jds.2016-10969","article-title":"Insulin signaling, inflammation, and lipolysis in subcutaneous adipose tissue of transition dairy cows either overfed energy during the prepartum period or fed a controlled-energy diet.","volume":"99","author":"Mann","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0047","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3168\/jds.2015-9908","article-title":"Dry period plane of energy: effects on glucose tolerance in transition dairy cows.","volume":"99","author":"Mann","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0048","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.3168\/jds.2015-9926","article-title":"Effect of dry period dietary energy level in dairy cattle on volume, concentration of immunoglobulin G, insulin, and fatty acid composition of colostrum.","volume":"99","author":"Mann","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0049","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.3168\/jds.2014-9024","article-title":"Dry period plane of energy: effects on feed intake, energy balance, milk production, and composition in transition dairy cows.","volume":"98","author":"Mann","year":"2015","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0050","doi-asserted-by":"crossref","first-page":"E15","DOI":"10.1152\/ajpendo.00645.2007","article-title":"Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage.","volume":"294","author":"Muniyappa","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"2022051715041652100_CIT0051","volume-title":"Nutrient requirements of beef cattle","author":"NASEM.","year":"2016","edition":"8"},{"key":"2022051715041652100_CIT0052","first-page":"237","author":"Overton","year":"1998"},{"key":"2022051715041652100_CIT0053","doi-asserted-by":"crossref","first-page":"R1316","DOI":"10.1152\/ajpregu.90575.2008","article-title":"Reappraisal of the intravenous glucose tolerance index for a simple assessment of insulin sensitivity in mice.","volume":"296","author":"Pacini","year":"2009","journal-title":"Am. J. Physiol. Integr. Comp. Physiol"},{"key":"2022051715041652100_CIT0054","doi-asserted-by":"crossref","first-page":"4776","DOI":"10.1210\/jcem.86.10.7902","article-title":"Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals.","volume":"86","author":"Perseghin","year":"2001","journal-title":"J. Clin. Endocrinol. Metab"},{"key":"2022051715041652100_CIT0055","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1017\/S0021859600063309","article-title":"Metabolism of the gravid uterus, foetus and utero-placenta at several stages of gestation in cows.","volume":"106","author":"Reynolds","year":"1986","journal-title":"J. Agric. Sci"},{"key":"2022051715041652100_CIT0056","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.3168\/jds.2020-18603","article-title":"Comparison of prepartum low-energy or high-energy diets with a 2-diet far-off and close-up strategy for multiparous and primiparous cows.","volume":"103","author":"Richards","year":"2020","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0057","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1071\/AN12293","article-title":"Nutritional management of the transition cow in the 21st century\u2014a paradigm shift in thinking.","volume":"53","author":"Roche","year":"2013","journal-title":"Anim. Prod. Sci"},{"key":"2022051715041652100_CIT0058","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1439-0396.1988.tb00190.x","article-title":"Somatomedin C and other hormones in dairy cows around parturition, in newborn calves and in milk.","volume":"60","author":"Ronge","year":"1988","journal-title":"J. Anim. Physiol. Anim. Nutr"},{"key":"2022051715041652100_CIT0059","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.3168\/jds.2016-11871","article-title":"Effects of dietary energy allowance and decline in dry matter intake during the dry period on responses to glucose and insulin in transition dairy cows.","volume":"100","author":"Salin","year":"2017","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0060","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.2527\/1991.6931122x","article-title":"Insulin responsiveness to glucose and tissue responsiveness to insulin in lactating, pregnant, and nonpregnant, nonlactating beef cows.","volume":"69","author":"Sano","year":"1991","journal-title":"J. Anim. Sci"},{"key":"2022051715041652100_CIT0061","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.3168\/jds.2011-4533","article-title":"Effects of plane of nutrition and 2,4-thiazolidinedione on insulin responses and adipose tissue gene expression in dairy cattle during late gestation.","volume":"94","author":"Schoenberg","year":"2011","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0062","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3168\/jds.2011-4529","article-title":"Effects of plane of nutrition and feed deprivation on insulin responses in dairy cattle during late gestation.","volume":"95","author":"Schoenberg","year":"2012","journal-title":"J. Dairy Sci"},{"key":"2022051715041652100_CIT0063","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2527\/2000.782456x","article-title":"Undegraded intake protein supplementation. II. Effects on plasma hormone and metabolite concentrations in periparturient beef cows fed low-quality hay during gestation and lactation.","volume":"78","author":"Sletmoen-Olson","year":"2000","journal-title":"J. Anim. Sci"},{"key":"2022051715041652100_CIT0064","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2006.05.170","article-title":"Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes.","volume":"346","author":"Song","year":"2006","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"2022051715041652100_CIT0065","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1083\/jcb.201802095","article-title":"Review: the cell biology of systemic insulin function.","volume":"217","author":"Tokarz","year":"2018","journal-title":"J. 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