{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:43:04Z","timestamp":1791996184436,"version":"4.4.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T00:00:00Z","timestamp":1649635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study was conducted to investigate the functional roles of an endo-\u03b2-1,4-xylanase on the intestinal health and growth performance of nursery pigs. A total of 60 pigs (21 d old, 6.9 \u00b1 0.8 kg body weight [BW]) were allotted based on a randomized complete block design with sex and initial BW as blocks. Dietary treatments had nutrients meeting the requirements with increasing levels of endo-\u03b2-1,4-xylanase (0, 220, 440, 880, 1,760 xylanase unit [XU] per kg feed) and fed to pigs in three phases (phases 1, 2, and 3 for 10, 14, and 14 d, respectively). Titanium dioxide (0.4%) was added to the phase 3 diets as an indigestible marker. On day 38, all pigs were euthanized to collect ileal digesta to measure apparent ileal digestibility (AID), jejunal digesta to measure viscosity, and jejunal mucosa to evaluate intestinal health. Data were analyzed using the MIXED procedure for polynomial contrasts and the NLMIXED procedure for broken line analysis of SAS. Increasing xylanase in the nursery diets reduced (linear, P &amp;lt; 0.05) the digesta viscosity in the jejunum. Increasing xylanase tended to reduce the relative abundance of Cupriavidus (P = 0.073) and Megasphaera (P = 0.063); tended to increase the relative abundance of Succinivibrio (P = 0.076) and Pseudomonas (P = 0.060); and had a quadratic effect (P &amp;lt; 0.05) on the relative abundance of Acinetobacter (maximum: 2.01% at 867 XU per kg feed). Xylanase from 0 to 1,087 XU per kg feed reduced (P &amp;lt; 0.05) jejunal malondialdehyde. Xylanase from 0 to 1,475 XU per kg feed increased (P &amp;lt; 0.05) the AID of neutral detergent fiber. Increasing xylanase increased (P &amp;lt; 0.05) the AID of ether extract and tended to increase (P = 0.058) the AID of crude protein. Increasing xylanase did not affect growth performance on overall period, whereas xylanase from 0 to 736 XU per kg feed increased (P &amp;lt; 0.05) average daily gain (ADG) during days 31 to 38. In conclusion, xylanase supplementation showed benefits on intestinal health by reducing digesta viscosity, the relative abundance of potentially harmful bacteria, and the oxidative stress in the jejunal mucosa, collectively enhancing intestinal morphology and the AID of nutrients. Xylanase supplementation at a range of 750 to 1,500 XU per kg feed provided benefits associated with reduced oxidative stress, increased nutrient digestibility, resulting in potential improvement on growth performance of nursery pigs by increasing the average daily feed intake and moderately improving the ADG throughout the last week of feeding.<\/jats:p>","DOI":"10.1093\/jas\/skac116","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T10:00:59Z","timestamp":1649671259000},"source":"Crossref","is-referenced-by-count":38,"title":["Functional roles of xylanase enhancing intestinal health and growth performance of nursery pigs by reducing the digesta viscosity and modulating the mucosa-associated microbiota in the jejunum"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9288-0567","authenticated-orcid":false,"given":"Vitor Hugo C","family":"Moita","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-336X","authenticated-orcid":false,"given":"Marcos Elias","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"2022051713574027600_CIT0001","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/J.ENG.2017.03.010","article-title":"Nutritional and metabolic consequences of feeding high-fiber diets to swine: a review","volume":"3","author":"Agyekum","year":"2017","journal-title":"Engineering"},{"key":"2022051713574027600_CIT0002","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1080\/0307945021000024544","article-title":"Necrotic enteritis: effect of barley, wheat and corn diets on proliferation of Clostridium perfringens type A","volume":"31","author":"Annett","year":"2002","journal-title":"Avian Pathol"},{"key":"2022051713574027600_CIT0003","volume-title":"Official methods of analysis","author":"AOAC.","year":"2006","edition":"18"},{"key":"2022051713574027600_CIT0004","volume-title":"Appendix F: guidelines for standard method performance requirements. 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