{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:48:01Z","timestamp":1792788481217,"version":"4.5.0"},"reference-count":134,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cattle induced to ovulate a small, physiologically immature preovulatory follicle had reduced oocyte developmental competence that resulted in decreased embryo cleavage and day 7 embryo quality compared with animals induced to ovulate a more advanced follicle. RNA-sequencing was performed on oocytes and their corresponding cumulus cells approximately 23 h after gonadotropin-releasing hormone (GnRH) administration to induce the preovulatory gonadotropin surge suggested reduced capacity for glucose metabolism and oxidative phosphorylation in the cumulus cells and oocytes from follicles \u226411.7 mm, respectively. We hypothesized that induced ovulation of a small, physiologically immature preovulatory follicle results in a suboptimal follicular microenvironment and reduced oocyte metabolic capacity. We performed a study with the objective to determine the impact of preovulatory follicle diameter and serum estradiol concentration at GnRH administration on oocyte metabolic competence and follicular fluid metabolome profiles. We synchronized the development of a preovulatory follicle and collected the follicle contents via transvaginal aspiration approximately 19 h after GnRH administration in lactating beef cows (n = 319). We determined ATP levels and mitochondrial DNA (mtDNA) copy number in 110 oocytes and performed ultra-high-performance liquid chromatography\u2013high resolution mass spectrometry metabolomic studies on 45 follicular fluid samples. Intraoocyte ATP and the amount of ATP produced per mtDNA copy number were associated with serum estradiol concentration at GnRH and time from GnRH administration to follicle aspiration (P &amp;lt; 0.05). mtDNA copy number was not related to follicle diameter at GnRH, serum estradiol concentration at GnRH, or any potential covariates (P &amp;gt; 0.10). We detected 90 metabolites in the aspirated follicular fluid. We identified 22 metabolites associated with serum estradiol concentration at GnRH and 63 metabolites associated with follicular fluid progesterone concentration at the time of follicle aspiration (FDR &amp;lt; 0.10). Pathway enrichment analysis of significant metabolites suggested altered proteinogenesis, citric acid cycle, and pyrimidine metabolism in follicles of reduced estrogenic capacity pre-gonadotropin surge or reduced progesterone production by the time of follicle aspiration.<\/jats:p>","DOI":"10.1093\/jas\/skac136","type":"journal-article","created":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T20:09:52Z","timestamp":1656619792000},"source":"Crossref","is-referenced-by-count":18,"title":["Preovulatory serum estradiol concentration is positively associated with oocyte ATP and follicular fluid metabolite abundance in lactating beef cattle"],"prefix":"10.1093","volume":"100","author":[{"given":"Casey C","family":"Read","sequence":"first","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Lannett","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Neal","family":"Schrick","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin D","family":"Rhinehart","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R","family":"Payton","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector F","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L","family":"Klabnik","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9243-3863","authenticated-orcid":false,"given":"Sarah E","family":"Moorey","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Tennessee , Knoxville, TN 37996 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,1]]},"reference":[{"key":"2022070100080279000_CIT0001","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.3390\/ani10122196","article-title":"Oocyte selection for in vitro embryo production in bovine species: noninvasive approaches for new challenges of oocyte competence","volume":"10","author":"Aguila","year":"2020","journal-title":"Animals (Basel)"},{"key":"2022070100080279000_CIT0002","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2527\/2000.7851291x","article-title":"Ovarian and endocrine characteristics during an estrous cycle in Angus, Brahman, and Senepol cows in a subtropical environment","volume":"78","author":"Alvarez","year":"2000","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0003","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1071\/RD13102","article-title":"Metabolic profile of serum and follicular fluid from postpartum dairy cows during summer and winter","volume":"26","author":"Alves","year":"2014","journal-title":"Reprod. Fertil. Dev"},{"key":"2022070100080279000_CIT0004","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.3168\/jds.S0022-0302(06)72581-4","article-title":"Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid","volume":"89","author":"Ambrose","year":"2006","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0005","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1095\/biolreprod.110.087411","article-title":"Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation","volume":"84","author":"Aparicio","year":"2011","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0006","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/mrd.1080390103","article-title":"Oocyte structure and follicular steroid concentrations in superovulated versus unstimulated heifers","volume":"39","author":"Assey","year":"1994","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0007","doi-asserted-by":"crossref","first-page":"722","DOI":"10.2527\/jas.2012-5368","article-title":"Pregnancy establishment and maintenance in cattle","volume":"91","author":"Atkins","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0008","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/GCO.0000000000000164","article-title":"Oocyte mitochondrial function and reproduction","volume":"27","author":"Babayev","year":"2015","journal-title":"Curr. Opin. Obstet"},{"key":"2022070100080279000_CIT0009","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S175173111800054X","article-title":"Review: using artificial insemination v. natural service in beef herds","volume":"12","author":"Baruselli","year":"2018","journal-title":"Animal"},{"key":"2022070100080279000_CIT0010","doi-asserted-by":"crossref","first-page":"E1089","DOI":"10.1152\/ajpendo.00209.2009","article-title":"Progesterone stimulates mitochondrial activity with subsequent inhibition of apoptosis in MCF-10A benign breast epithelial cells","volume":"297","author":"Behera","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab"},{"key":"2022070100080279000_CIT0011","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1530\/REP-10-0068","article-title":"Metabolite concentrations in follicular fluid may explain differences in fertility between heifers and lactating cows","volume":"139","author":"Bender","year":"2010","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0012","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1073\/pnas.58.2.560","article-title":"The pattern of energy metabolism in the mouse oocyte and zygote","volume":"58","author":"Biggers","year":"1967","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"2022070100080279000_CIT0013","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0093-691X(96)00290-7","article-title":"Superovulation can reduce the developmental competence of bovine embryos","volume":"46","author":"Blondin","year":"1996","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0014","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/mrd.1080410109","article-title":"Oocyte and follicular morphology as determining characteristics for developmental competence in bovine oocytes","volume":"41","author":"Blondin","year":"1995","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0015","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.theriogenology.2020.09.033","article-title":"Comparison of the 7 & 7 Synch protocol and the 7-day CO-Synch + CIDR protocol among recipient beef cows in an embryo transfer program","volume":"158","author":"Bonacker","year":"2020","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0016","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1530\/REP-16-0426","article-title":"Failure to launch: aberrant cumulus gene expression during oocyte in vitro maturation","volume":"153","author":"Brown","year":"2017","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0017","doi-asserted-by":"crossref","first-page":"553","DOI":"10.2527\/jas.2007-0570","article-title":"Effect of ovulatory follicle size and expression of estrus on progesterone secretion in beef cows","volume":"86","author":"Busch","year":"2008","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0018","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/dvg.1020160108","article-title":"Polarization of mitochondria in the unfertilized mouse oocyte","volume":"16","author":"Calarco","year":"1995","journal-title":"Dev. Genet"},{"key":"2022070100080279000_CIT0019","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol"},{"key":"2022070100080279000_CIT0020","doi-asserted-by":"crossref","first-page":"183024","DOI":"10.1155\/2013\/183024","article-title":"The role of mitochondria from mature oocyte to viable blastocyst","volume":"2013","author":"Chappel","year":"2013","journal-title":"Obstet. Gynecol. Int"},{"key":"2022070100080279000_CIT0021","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1095\/biolreprod.109.077776","article-title":"Embryo mitochondrial DNA depletion is reversed during early embryogenesis in cattle","volume":"82","author":"Chiaratti","year":"2010","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0022","doi-asserted-by":"crossref","first-page":"106723","DOI":"10.1016\/j.anireprosci.2021.106723","article-title":"Effect of estradiol preceding and progesterone subsequent to ovulation on proportion of postpartum beef cows pregnant","volume":"227","author":"Ciernia","year":"2021","journal-title":"Anim. Reprod. Sci"},{"key":"2022070100080279000_CIT0023","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.116.142141","article-title":"Spatial characterization of bioenergetics and metabolism of primordial to preovulatory follicles in whole ex vivo murine ovary","volume":"95","author":"Cinco","year":"2016","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0024","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/0471250953.bi1411s37","article-title":"LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine.","volume-title":"Current protocols in bioinformatics","author":"Clasquin","year":"2012"},{"key":"2022070100080279000_CIT0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/humupd\/dmx040","article-title":"Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events","volume":"24","author":"Conti","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"2022070100080279000_CIT0026","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.mce.2011.11.002","article-title":"Novel signaling mechanisms in the ovary during oocyte maturation and ovulation","volume":"356","author":"Conti","year":"2012","journal-title":"Mol. Cell. Endocrinol"},{"key":"2022070100080279000_CIT0027","first-page":"2569","article-title":"Estrous expression during a fixed-time artificial insemination protocol enhances development and interferon-tau messenger RNA expression in conceptuses from Bos indicus beef cows","volume":"13","author":"Cooke","year":"2019","journal-title":"Int. J. Animal Sci"},{"key":"2022070100080279000_CIT0028","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/humupd\/dmv011","article-title":"Oocyte maturation: gamete-somatic cells interactions, meiotic resumption, cytoskeletal dynamics and cytoplasmic reorganization","volume":"21","author":"Coticchio","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"2022070100080279000_CIT0029","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.2527\/jas.2007-0136","article-title":"Characterization of biological types of cattle (cycle VII): influence of postpartum interval and estrous cycle length on fertility","volume":"85","author":"Cushman","year":"2007","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0030","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.2527\/jas.2013-6465","article-title":"Heifer calving date positively influences calf weaning weights through six parturitions","volume":"91","author":"Cushman","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0031","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10815-018-1143-3","article-title":"Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications","volume":"35","author":"Da Broi","year":"2018","journal-title":"J. Assist. Reprod. Genet"},{"key":"2022070100080279000_CIT0032","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.theriogenology.2016.09.039","article-title":"Effect of follicular aging on ATP content and mitochondria distribution in bovine oocytes","volume":"89","author":"Dadarwal","year":"2017","journal-title":"Theriogenology"},{"issue":"2","key":"2022070100080279000_CIT0033","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1210\/js.2018-00219","article-title":"A mitochondrial progesterone receptor increases cardiac beta-oxidation and remodeling","volume":"3","author":"Dai","year":"2019","journal-title":"J. Endocr. Soc"},{"key":"2022070100080279000_CIT0034","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1007\/s43032-019-00132-2","article-title":"Progesterone increases mitochondria membrane potential in non-human primate oocytes and embryos","volume":"27","author":"Dai","year":"2020","journal-title":"Reprod. Sci"},{"key":"2022070100080279000_CIT0035","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3390\/cells9041002","article-title":"A comparative analysis of oocyte development in mammals","volume":"9","author":"Dalbies-Tran","year":"2020","journal-title":"Cells"},{"key":"2022070100080279000_CIT0036","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.24457","article-title":"Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption","volume":"229","author":"Dalton","year":"2014","journal-title":"J. Cell. Physiol"},{"key":"2022070100080279000_CIT0037","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1093\/tas\/txy020","article-title":"Effect of calving period on beef cow longevity and lifetime productivity in western Canada","volume":"2","author":"Damiran","year":"2018","journal-title":"Transl. Anim. Sci"},{"key":"2022070100080279000_CIT0038","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0093-691X(91)90449-N","article-title":"Morphology of preovulatory bovine follicles as related to oocyte maturation","volume":"35","author":"de Loos","year":"1991","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0039","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0093-691X(01)00655-0","article-title":"Effects of in vivo prematuration and in vivo final maturation on developmental capacity and quality of pre-implantation embryos","volume":"57","author":"Dieleman","year":"2002","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0040","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-13-0251","article-title":"Lipids and oocyte developmental competence: the role of fatty acids and \u03b2-oxidation","volume":"148","author":"Dunning","year":"2014","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0041","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s004290050052","article-title":"Oocyte ultrastructure in bovine primordial to early tertiary follicles","volume":"195","author":"Fair","year":"1997","journal-title":"Anat. Embryol"},{"key":"2022070100080279000_CIT0042","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/mrd.1080420410","article-title":"Bovine oocyte diameter in relation to maturational competence and transcriptional activity","volume":"42","author":"Fair","year":"1995","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0043","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbi.2004.03.007","article-title":"Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport","volume":"7","author":"Fernie","year":"2004","journal-title":"Curr. Opin Plant Biol"},{"key":"2022070100080279000_CIT0044","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/biolre\/iox148","article-title":"Quantitative proteomic profiling of bovine follicular fluid during follicle development","volume":"97","author":"Ferrazza","year":"2017","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0045","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1210\/me.2012-1065","article-title":"Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands","volume":"26","author":"Firestone","year":"2012","journal-title":"Mol. Endocrinol"},{"key":"2022070100080279000_CIT0046","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1071\/RD14348","article-title":"Lactation-induced changes in metabolic status and follicular-fluid metabolomic profile in postpartum dairy cows","volume":"28","author":"Forde","year":"2016","journal-title":"Reprod. Fertil. Dev"},{"key":"2022070100080279000_CIT0047","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1095\/biolreprod32.5.1069","article-title":"Concentrations of steroids and gonadotropins in follicular fluid from normal heifers and heifers primed for superovulation","volume":"32","author":"Fortune","year":"1985","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0048","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.anireprosci.2004.04.031","article-title":"Follicular development: the role of the follicular microenvironment in selection of the dominant follicle","volume":"8","author":"Fortune","year":"2004","journal-title":"Anim. Reprod. Sci"},{"key":"2022070100080279000_CIT0049","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.2527\/jas.2012-5263","article-title":"Effect of calving distribution on beef cattle progeny performance","volume":"90","author":"Funston","year":"2012","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0050","first-page":"864","article-title":"Suppression of mitochondrial oxidative phosphorylation on in vitro maturation, fertilization and developmental competence of oocytes","volume":"45","author":"Ge","year":"2013","journal-title":"Beijing Da Xue Xue Bao Yi Xue Ban"},{"key":"2022070100080279000_CIT0051","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2527\/2001.7911","article-title":"Calf removal improves conception rates to the Ovsynch and CO-Synch protocols","volume":"79","author":"Geary","year":"2001","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0052","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.3168\/jds.2011-5155","article-title":"Effect of progesterone on magnitude of the luteinizing hormone surge induced by two different doses of gonadotropin-releasing hormone in lactating dairy cows","volume":"95","author":"Giordano","year":"2012","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0053","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ando.2010.02.021","article-title":"Human ovarian follicular development: from activation of resting follicles to preovulatory maturation","volume":"71","author":"Gougeon","year":"2010","journal-title":"Annales d\u2019endocrinologie"},{"key":"2022070100080279000_CIT0054","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1043-2760(02)00623-9","article-title":"The ovarian gap junction protein connexin43: regulation by gonadotropins","volume":"13","author":"Granot","year":"2002","journal-title":"Trends Endocrinol. Metab"},{"key":"2022070100080279000_CIT0055","doi-asserted-by":"crossref","first-page":"458","DOI":"10.3389\/fvets.2020.00458","article-title":"Muscle metabolome profiles in woody breast-(un)affected broilers: effects of quantum blue phytase-enriched diet","volume":"7","author":"Greene","year":"2020","journal-title":"Front. Vet. Sci"},{"key":"2022070100080279000_CIT0056","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S1672-0229(08)60004-2","article-title":"Reconstruction of pathways associated with amino acid metabolism in human mitochondria","volume":"5","author":"Guda","year":"2007","journal-title":"Genom. Proteom. Bioinform"},{"issue":"4","key":"2022070100080279000_CIT0057","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/(SICI)1098-2795(199908)53:4<451::AID-MRD11>3.0.CO;2-3","article-title":"Development during single IVP of bovine oocytes from dissected follicles: interactive effects of estrous cycle stage, follicle size and atresia","volume":"53","author":"Hagemann","year":"1999","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0058","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.1038\/s41598-019-41610-6","article-title":"Mitochondrial function in immature bovine oocytes is improved by an increase of cellular cyclic AMP","volume":"9","author":"Hashimoto","year":"2019","journal-title":"Sci. Rep"},{"key":"2022070100080279000_CIT0059","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1387\/ijdb.120133cc","article-title":"The antral follicle: a microenvironment for oocyte differentiation","volume":"56","author":"Hennet","year":"2012","journal-title":"Int. J. Dev. Biol"},{"key":"2022070100080279000_CIT0060","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1530\/jrf.0.0760645","article-title":"Ultrastructural features of preovulatory oocyte maturation in superovulated cattle","volume":"76","author":"Hyttel","year":"1986","journal-title":"J. Reprod. Fertil"},{"key":"2022070100080279000_CIT0061","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0093-691X(96)00336-6","article-title":"Oocyte growth, capacitation and final maturation in cattle","volume":"47","author":"Hyttel","year":"1997","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0062","first-page":"35","article-title":"Ultrastructural aspects of oocyte maturation and fertilization in cattle","volume":"38","author":"Hyttel","year":"1989","journal-title":"J. Reprod. Fertil. Suppl"},{"key":"2022070100080279000_CIT0063","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1071\/RD10133","article-title":"Effect of maternal age on mitochondrial DNA copy number, ATP content and IVF outcome of bovine oocytes","volume":"23","author":"Iwata","year":"2011","journal-title":"Reprod. Fertil. Dev"},{"key":"2022070100080279000_CIT0064","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1530\/rep.1.00084","article-title":"Effects of follicle size and electrolytes and glucose in maturation medium on nuclear maturation and developmental competence of bovine oocytes","volume":"127","author":"Iwata","year":"2004","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0065","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.theriogenology.2009.04.015","article-title":"Effect of cytoplasmic lipid content on in vitro developmental efficiency of bovine IVP embryos","volume":"72","author":"Jeong","year":"2009","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0066","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/mrd.20698","article-title":"Effect of oocyte mitochondrial DNA haplotype on bovine somatic cell nuclear transfer efficiency","volume":"74","author":"Jiao","year":"2007","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0067","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.2527\/jas.2012-5611","article-title":"Preovulatory estradiol and the establishment and maintenance of pregnancy in suckled beef cows","volume":"91","author":"Jinks","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0068","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1095\/biolreprod.106.059899","article-title":"Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo","volume":"77","author":"Johnson","year":"2007","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0069","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3168\/jds.S0022-0302(97)75935-6","article-title":"Follicular function in lactating dairy cows treated with sustained-release bovine somatotropin","volume":"80","author":"Kirby","year":"1997","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0070","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-animal-031412-103647","article-title":"In vivo and in vitro environmental effects on mammalian oocyte quality","volume":"1","author":"Krisher","year":"2013","journal-title":"Annu. Rev. Anim. Biosci"},{"key":"2022070100080279000_CIT0071","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/mrd.22651","article-title":"Transcriptome analysis of bovine oocytes from distinct follicle sizes: insights from correlation network analysis","volume":"83","author":"Labrecque","year":"2016","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0072","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.cvfa.2016.01.006","article-title":"Synchronization and artificial insemination strategies in beef cattle","volume":"32","author":"Lamb","year":"2016","journal-title":"Vet. Clin. North Am. Food Anim. Pract"},{"key":"2022070100080279000_CIT0073","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.2527\/2001.7992253x","article-title":"Inclusion of an intravaginal progesterone insert plus GnRH and prostaglandin F2\u03b1 for ovulation control in postpartum suckled beef cows","volume":"79","author":"Lamb","year":"2001","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0074","doi-asserted-by":"crossref","first-page":"8781","DOI":"10.1038\/s41598-021-88251-2","article-title":"Progesterone receptor membrane component 1 reduces cardiac steatosis and lipotoxicity via activation of fatty acid oxidation and mitochondrial respiration","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep"},{"key":"2022070100080279000_CIT0075","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0093-691X(99)00133-8","article-title":"Improved in vitro embryo development using in vivo matured oocytes from heifers superovulated with a controlled preovulatory LH surge","volume":"52","author":"van de Leemput","year":"1999","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0076","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD11901","article-title":"Intrafollicular conditions as a major link between maternal metabolism and oocyte quality: a focus on dairy cow fertility","volume":"24","author":"Leroy","year":"2011","journal-title":"Reprod. Fertil. Dev"},{"key":"2022070100080279000_CIT0077","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1439-0531.2006.00650.x","article-title":"The in vitro development of bovine oocytes after maturation in glucose and beta-hydroxybutyrate concentrations associated with negative energy balance in dairy cows","volume":"41","author":"Leroy","year":"2006","journal-title":"Reprod. Domest. Anim"},{"issue":"9","key":"2022070100080279000_CIT0078","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.3168\/jds.2009-2789","article-title":"Economic comparison of natural service and timed artificial insemination breeding programs in dairy cattle","volume":"93","author":"Lima","year":"2010","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0079","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1007\/s12020-012-9706-z","article-title":"Comparison of follicular fluid amphiregulin and EGF concentrations in patients undergoing IVF with different stimulation protocols","volume":"42","author":"Liu","year":"2012","journal-title":"Endocrine"},{"key":"2022070100080279000_CIT0080","doi-asserted-by":"crossref","first-page":"e2662","DOI":"10.1038\/cddis.2017.82","article-title":"Estrogen receptors in granulosa cells govern meiotic resumption of pre-ovulatory oocytes in mammals","volume":"8","author":"Liu","year":"2017","journal-title":"Cell Death Dis"},{"key":"2022070100080279000_CIT0081","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/mrd.1080370107","article-title":"Effect of follicle size on bovine oocyte quality and developmental competence following maturation, fertilization, and culture in vitro","volume":"37","author":"Lonergan","year":"1994","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0082","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.2527\/jas.2005-698","article-title":"Genetic partitioning of variation in ovulatory follicle size and probability of pregnancy in beef cattle1","volume":"84","author":"MacNeil","year":"2006","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0083","doi-asserted-by":"crossref","first-page":"e0248453","DOI":"10.1371\/journal.pone.0248453","article-title":"Plasma concentrations of progesterone in the preceding estrous cycle are associated with the intensity of estrus and fertility of Holstein cows","volume":"16","author":"Madureira","year":"2021","journal-title":"PLoS One"},{"key":"2022070100080279000_CIT0084","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.theriogenology.2012.04.002","article-title":"Regulation of oocyte mitochondrial DNA copy number by follicular fluid, EGF, and neuregulin 1 during in vitro maturation affects embryo development in pigs","volume":"78","author":"Mao","year":"2012","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0085","doi-asserted-by":"crossref","first-page":"R110.000133","DOI":"10.1074\/mcp.R110.000133","article-title":"mzML - a community standard for mass spectrometry data","volume":"10","author":"Martens","year":"2011","journal-title":"Mol. Cell. Proteomics"},{"key":"2022070100080279000_CIT0086","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat. Commun"},{"key":"2022070100080279000_CIT0087","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0070-2153(06)77003-X","article-title":"Mitochondrial DNA in the oocyte and the developing embryo","volume":"77","author":"May-Panloup","year":"2007","journal-title":"Curr. Top. Dev. Biol"},{"key":"2022070100080279000_CIT0088","doi-asserted-by":"crossref","first-page":"9818","DOI":"10.1021\/ac1021166","article-title":"Metabolomic analysis and visualization engine for LC-MS data","volume":"82","author":"Melamud","year":"2010","journal-title":"Anal. Chem"},{"key":"2022070100080279000_CIT0089","first-page":"449","article-title":"Aspects of follicular and oocyte maturation that affect the developmental potential of embryos","volume":"54","author":"Mermillod","year":"1999","journal-title":"J. Reprod. Fertil. Suppl"},{"key":"2022070100080279000_CIT0090","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0093-691X(02)01246-3","article-title":"Factors affecting oocyte quality and quantity in commercial application of embryo technologies in the cattle breeding industry","volume":"59","author":"Merton","year":"2003","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0091","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/genes12060893","article-title":"Differential transcript profiles in cumulus-oocyte complexes originating from pre-ovulatory follicles of varied physiological maturity in beef cows","volume":"12","author":"Moorey","year":"2021","journal-title":"Genes"},{"issue":"4","key":"2022070100080279000_CIT0092","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.fertnstert.2015.07.001","article-title":"Follicular fluid and mural granulosa cells microRNA profiles vary in in vitro fertilization patients depending on their age and oocyte maturation stage","volume":"104","author":"Moreno","year":"2015","journal-title":"Fertil. Steril"},{"key":"2022070100080279000_CIT0093","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ygeno.2014.07.006","article-title":"Negative energy balance affects imprint stability in oocytes recovered from postpartum dairy cows","volume":"104","author":"O\u2019Doherty","year":"2014","journal-title":"Genomics"},{"key":"2022070100080279000_CIT0094","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0093-691X(97)00300-2","article-title":"Bovine oocyte diameter in relation to developmental competence","volume":"48","author":"Otoi","year":"1997","journal-title":"Theriogenology"},{"key":"2022070100080279000_CIT0095","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1095\/biolreprod.113.108548","article-title":"Comparative importance of fatty acid beta-oxidation to nuclear maturation, gene expression, and glucose metabolism in mouse, bovine, and porcine cumulus oocyte complexes","volume":"88","author":"Paczkowski","year":"2013","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0096","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.rbmo.2014.03.010","article-title":"Influence of ovarian stimulation for IVF\/ICSI on the antioxidant defence system and relationship to outcome","volume":"29","author":"Palini","year":"2014","journal-title":"Reprod. Biomed. Online"},{"key":"2022070100080279000_CIT0097","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"2022070100080279000_CIT0098","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/mrd.1080310111","article-title":"Fertilization and developmental competence of bovine oocytes derived from different categories of antral follicles","volume":"31","author":"Pavlok","year":"1992","journal-title":"Mol. Reprod. Dev"},{"key":"2022070100080279000_CIT0099","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1262\/jrd.2017-160","article-title":"Mitochondrial-related consequences of heat stress exposure during bovine oocyte maturation persist in early embryo development","volume":"64","author":"Payton","year":"2018","journal-title":"J. Reprod. Dev"},{"key":"2022070100080279000_CIT0100","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1073\/pnas.0501700102","article-title":"Relationship between follicle size at insemination and pregnancy success","volume":"102","author":"Perry","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S .A"},{"key":"2022070100080279000_CIT0101","doi-asserted-by":"crossref","first-page":"684","DOI":"10.2527\/jas.2006-519","article-title":"Relationship between size of the ovulatory follicle and pregnancy success in beef heifers","volume":"85","author":"Perry","year":"2007","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0102","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.domaniend.2014.02.001","article-title":"Relationship of follicle size and concentrations of estradiol among cows exhibiting or not exhibiting estrus during a fixed-time AI protocol","volume":"48","author":"Perry","year":"2014","journal-title":"Domest. Anim. Endocrinol"},{"key":"2022070100080279000_CIT0103","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.3168\/jds.2015-10192","article-title":"Circulating concentrations of bovine pregnancy-associated glycoproteins and late embryonic mortality in lactating dairy herds","volume":"99","author":"Pohler","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0104","doi-asserted-by":"crossref","first-page":"6188","DOI":"10.3168\/jds.2015-9473","article-title":"Concentrations of luteinizing hormone and ovulatory responses in dairy cows before timed artificial insemination","volume":"98","author":"Pulley","year":"2015","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/jrf.0.0350301","article-title":"The relationships between the ATP content of preimplantation mouse embryos and their development in vitro during culture","volume":"35","author":"Quinn","year":"1973","journal-title":"J. Reprod. Fertil"},{"key":"2022070100080279000_CIT0106","author":"R Core Team","year":"2020"},{"key":"2022070100080279000_CIT0107","doi-asserted-by":"crossref","DOI":"10.3390\/mps4040088","article-title":"Concurrent measurement of mitochondrial DNA copy number and ATP concentration in single bovine oocytes","volume":"4","author":"Read","year":"2021","journal-title":"Methods Protoc"},{"key":"2022070100080279000_CIT0108","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11090623","article-title":"Correlation between pre-ovulatory follicle diameter and follicular fluid metabolome profiles in lactating beef cows","volume":"11","author":"Read","year":"2021","journal-title":"Metabolites"},{"key":"2022070100080279000_CIT0109","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/biology6030035","article-title":"The role of oocyte organelles in determining developmental competence","volume":"6","author":"Reader","year":"2017","journal-title":"Biology"},{"key":"2022070100080279000_CIT0110","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/molehr\/7.5.425","article-title":"Mitochondrial DNA content affects the fertilizability of human oocytes","volume":"7","author":"Reynier","year":"2001","journal-title":"Mol. Hum. Reprod"},{"key":"2022070100080279000_CIT0111","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/humupd\/dmaa043","article-title":"Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence","volume":"27","author":"Richani","year":"2021","journal-title":"Hum. Reprod. Update"},{"key":"2022070100080279000_CIT0112","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0303-7207(98)00168-3","article-title":"Molecular mechanisms of ovulation and luteinization","volume":"145","author":"Richards","year":"1998","journal-title":"Mol. Cell. Endocrinol"},{"key":"2022070100080279000_CIT0113","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.anireprosci.2016.01.013","article-title":"Expression of estrus before fixed-time AI affects conception rates and factors that impact expression of estrus and the repeatability of expression of estrus in sequential breeding seasons","volume":"166","author":"Richardson","year":"2016","journal-title":"Anim. Reprod. Sci"},{"key":"2022070100080279000_CIT0114","doi-asserted-by":"crossref","first-page":"e0227095","DOI":"10.1371\/journal.pone.0227095","article-title":"Heat-induced hyperthermia impacts the follicular fluid proteome of the periovulatory follicle in lactating dairy cows","volume":"14","author":"Rispoli","year":"2019","journal-title":"PLoS One"},{"key":"2022070100080279000_CIT0115","doi-asserted-by":"crossref","first-page":"e012","DOI":"10.1621\/nrs.07012","article-title":"Control of oocyte release by progesterone receptor-regulated gene expression","volume":"7","author":"Robker","year":"2009","journal-title":"Nucl. Recept. Signal"},{"key":"2022070100080279000_CIT0116","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.2527\/jas.2011-4836","article-title":"An economic evaluation of estrous synchronization and timed artificial insemination in suckled beef cows","volume":"90","author":"Rodgers","year":"2012","journal-title":"J. Anim. Sci"},{"key":"2022070100080279000_CIT0117","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anireprosci.2010.03.007","article-title":"Ovarian follicle diameter at timed insemination and estrous response influence likelihood of ovulation and pregnancy after estrous synchronization with progesterone or progestin-based protocols in suckled Bos indicus cows","volume":"120","author":"S\u00e1 Filho","year":"2010","journal-title":"Anim. Reprod. Sci"},{"key":"2022070100080279000_CIT0118","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1095\/biolreprod.114.120931","article-title":"The adenosine salvage pathway as an alternative to mitochondrial production of ATP in maturing mammalian oocytes","volume":"91","author":"Scantland","year":"2014","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0119","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1095\/biolreprod40.6.1257","article-title":"Timing of nuclear progression and protein synthesis necessary for meiotic maturation of bovine oocytes","volume":"40","author":"Sirard","year":"1989","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0120","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1095\/biolreprod64.3.904","article-title":"Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture","volume":"64","author":"Stojkovic","year":"2001","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0121","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1439-0531.2009.01402.x","article-title":"Role of fatty acids in energy provision during oocyte maturation and early embryo development","volume":"44","author":"Sturmey","year":"2009","journal-title":"Reprod. Domest. Anim"},{"key":"2022070100080279000_CIT0122","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1530\/REP-09-0345","article-title":"The pivotal role of glucose metabolism in determining oocyte developmental competence","volume":"139","author":"Sutton-McDowall","year":"2010","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0123","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/humupd\/dmn025","article-title":"ART failure: oocyte contributions to unsuccessful fertilization","volume":"14","author":"Swain","year":"2008","journal-title":"Hum. Reprod. Update"},{"key":"2022070100080279000_CIT0124","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1071\/RD15228","article-title":"Age-associated deterioration in follicular fluid induces a decline in bovine oocyte quality","volume":"29","author":"Takeo","year":"2017","journal-title":"Reprod. Fertil. Dev"},{"key":"2022070100080279000_CIT0125","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1095\/biolreprod.103.026104","article-title":"In vitro embryo production efficiency in cattle and its association with oocyte adenosine triphosphate content, quantity of mitochondrial DNA, and mitochondrial DNA haplogroup","volume":"71","author":"Tamassia","year":"2004","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0126","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1046\/j.1439-0442.2000.00281.x","article-title":"Serum progesterone levels in post-partum dairy cows after repeated application of the prostaglandin F2 alpha analogue D (+) cloprostenol sodium","volume":"47","author":"Tenhagen","year":"2000","journal-title":"J. Vet. Med. A Physiol. Pathol. Clin. Med"},{"key":"2022070100080279000_CIT0127","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.fertnstert.2008.12.129","article-title":"Age-related variations in follicular apolipoproteins may influence human oocyte maturation and fertility potential","volume":"93","author":"Von Wald","year":"2010","journal-title":"Fertil. Steril"},{"key":"2022070100080279000_CIT0128","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1095\/biolreprod.109.080887","article-title":"The role of mitochondrial DNA copy number in mammalian fertility","volume":"83","author":"Wai","year":"2010","journal-title":"Biol. Reprod"},{"key":"2022070100080279000_CIT0129","volume-title":"Weight change, body condition and beef cow reproduction","author":"Whitman","year":"1975"},{"key":"2022070100080279000_CIT0130","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/humupd\/dmv007","article-title":"Gap junction connexins in female reproductive organs: implications for women\u2019s reproductive health","volume":"21","author":"Winterhager","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"2022070100080279000_CIT0131","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1530\/REP-09-0219","article-title":"Dietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos","volume":"139","author":"Wonnacott","year":"2010","journal-title":"Reproduction"},{"key":"2022070100080279000_CIT0132","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3168\/jds.2009-2167","article-title":"Effects of dietary fats differing in n-6:n-3 ratio fed to high-yielding dairy cows on fatty acid composition of ovarian compartments, follicular status, and oocyte quality","volume":"93","author":"Zachut","year":"2010","journal-title":"J. Dairy Sci"},{"key":"2022070100080279000_CIT0133","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jprot.2016.03.027","article-title":"Proteomic analysis of preovulatory follicular fluid reveals differentially abundant proteins in less fertile dairy cows","volume":"139","author":"Zachut","year":"2016","journal-title":"J. Proteom"},{"key":"2022070100080279000_CIT0134","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1071\/RD14441","article-title":"Maternal control of early embryogenesis in mammals","volume":"27","author":"Zhang","year":"2015","journal-title":"Reprod. Fertil. Dev"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/100\/7\/skac136\/44301735\/skac136.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/100\/7\/skac136\/44301735\/skac136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,30]],"date-time":"2022-06-30T20:11:13Z","timestamp":1656619873000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skac136\/6620784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":134,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7,1]]},"published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/skac136","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2022,7,1]]},"article-number":"skac136"}}