{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T07:20:44Z","timestamp":1766647244300,"version":"3.41.2"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31802101"],"award-info":[{"award-number":["31802101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["KJQN201935"],"award-info":[{"award-number":["KJQN201935"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study investigated whether bamboo leaf extract (BLE) could improve the growth performance, antioxidant capacity, and inhibit hepatic apoptosis in suckling piglets. Sixty-four suckling piglets were orally gavaged with vehicle (CON group) or 100, 200, or 300 mg BLE\/kg body weight (BL, BM, and BH groups) at 3 d of age for 21 d (n = 8). The results showed that BLE treatment had no effects on the growth performance (P &amp;gt; 0.05). Compared with the CON group, the BM and BH groups decreased (P &amp;lt; 0.05) the jejunal and hepatic malondialdehyde (MDA) contents. Supplementation with BLE increased antioxidant enzymes activities and the expressions of nuclear factor erythroid 2-related factor 2 (Nrf2) and several targeted genes in the jejunum and liver of suckling piglets. The hepatic apoptosis rate was lower (P &amp;lt; 0.05) in BLE treatment than in the CON group. Compared with the CON group, the BLE groups showed increased (P &amp;lt; 0.05) mRNA levels of B-cell-lymphoma protein 2 (BCL-2), whereas decreased (P &amp;lt; 0.05) BCL-2-associated X (BAX) and cysteine aspartate specific protease-3 (caspase-3) mRNA levels. The results of protein expressions of BCL-2 and caspase-3 were consistent with those of mRNA levels. Altogether, our results indicated that BLE intervention can improve the antioxidant capacity and inhibit hepatic apoptosis in suckling piglets.<\/jats:p>","DOI":"10.1093\/jas\/skac201","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T01:02:51Z","timestamp":1654045371000},"source":"Crossref","is-referenced-by-count":7,"title":["Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets"],"prefix":"10.1093","volume":"100","author":[{"given":"Ge","family":"Yu","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuli","family":"Ji","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Cheng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peilu","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-5009","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu , 210095 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,31]]},"reference":[{"key":"2022070703271588700_CIT0001","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.biopha.2018.12.112","article-title":"Olea europaea leaf extract up-regulates Nrf2\/ARE\/HO-1 signaling and attenuates cyclophosphamide-induced oxidative stress, inflammation and apoptosis in rat kidney","volume":"111","author":"ALHaithloul","year":"2019","journal-title":"Biomed. 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