{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T02:26:40Z","timestamp":1791599200004,"version":"4.3.4"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Adare Biome"},{"DOI":"10.13039\/100009591","name":"North Carolina Agricultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009591","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study determined the supplemental effects of Lactobacillus fermentate (LBF, Adare Biome, France) on intestinal health and prevention of postweaning diarrhea caused by F18+Escherichia coli in nursery pigs. Sixty-four weaned pigs (6.6 \u00b1 0.7 kg body weight) were allotted in a randomized complete block design to four treatments: NC: no challenge\/no supplement; PC: E. coli challenge\/no supplement; AGP: E. coli challenge\/bacitracin (30 g\/t feed); and PBT: E. coli challenge\/LBF (2 kg\/t feed). Bacitracin methylene disalicylate (BMD) was used as a source of bacitracin. On day 7, challenged groups were orally inoculated with F18+E. coli (2.4 \u00d7 1010 CFU), whereas NC received sterile saline solution. Growth performance was analyzed weekly, and pigs were euthanized at the end of 28 d feeding to analyze intestinal health. Data were analyzed using the Mixed procedure of SAS 9.4. During the post-challenge period, PC tended to decrease (P = 0.067) average daily gain (ADG) when compared with NC, whereas AGP increased (P &amp;lt; 0.05) when compared with PC; PBT tended to increase (P = 0.081) ADG when compared with PC. The PC increased fecal score (P &amp;lt; 0.05) during day 7 to 14 when compared with NC, whereas AGP decreased it (P &amp;lt; 0.05) during day 14 to 21 when compared with PC. The PC increased (P &amp;lt; 0.05) protein carbonyl, crypt cell proliferation, and the relative abundance of Helicobacter rodentium when compared with NC. However, AGP decreased (P &amp;lt; 0.05) crypt cell proliferation and H. rodentium and increased (P &amp;lt; 0.05) villus height, Bifidobacterium boum, Pelomonas spp., and Microbacterium ginsengisoli when compared with PC. The PBT reduced (P &amp;lt; 0.05) crypt cell proliferation and H. rodentium and increased (P &amp;lt; 0.05) Lactobacillus salivarius and Propionibacterium acnes when compared with PC. At the genus level, AGP and PBT increased (P &amp;lt; 0.05) the alpha diversity of jejunal mucosa-associated microbiota in pigs estimated with Chao1 richness estimator when compared with PC. Collectively, F18+E. coli reduced growth performance by adversely affecting microbiota and intestinal health. The LBF and BMD improved growth performance, and it was related to the enhanced intestinal health and increased diversity and abundance of beneficial microbiota in pigs challenged with F18+E. coli.<\/jats:p>","DOI":"10.1093\/jas\/skac210","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T20:20:55Z","timestamp":1654546855000},"source":"Crossref","is-referenced-by-count":68,"title":["Postbiotic effects of <i>Lactobacillus<\/i> fermentate on intestinal health, mucosa-associated microbiota, and growth efficiency of nursery pigs challenged with F18+<i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"100","author":[{"given":"Xiangyi","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-336X","authenticated-orcid":false,"given":"Marcos Elias","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"2022081814441194700_CIT0001","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3109\/08923973.2012.672425","article-title":"Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs","volume":"34","author":"Arimori","year":"2012","journal-title":"Immunopharmacol. 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