{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T07:47:43Z","timestamp":1782546463738,"version":"3.54.5"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005825","name":"USDA National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["SD00H682-19"],"award-info":[{"award-number":["SD00H682-19"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A total of 2,430 pigs (DNA 600 \u00d7 Topigs Norsvin 70, initially 39.4 kg) were used in a 28-d trial to determine the standardized ileal digestible (SID) Val:Lys requirement for pigs fed with diets containing 30% DDGS. Treatments included five diets containing 30% DDGS with SID Val:Lys ratios of 60%, 65%, 70%, 75%, and 80%, plus a corn soybean meal (SBM) diet, for a total of six dietary treatments. Diets were formulated to be isocaloric through the inclusion of fat and to contain equal amounts of SID Lys within phase. Pens were assigned to dietary treatment in a randomized complete block design with initial body weight (BW) as the random blocking factor. Each dietary treatment was replicated 15 times and pens contained 27 pigs, balanced for sex. Increasing the SID Val:Lys ratio in diets containing 30% DDGS increased (Quadratic; P \u2264 0.007) 14-d BW, final BW, average daily gain (ADG), average daily feed intake (ADFI), and gain:feed (G:F) for all periods. Providing an SID Val:Lys ratio of 75% resulted in the heaviest 14-d BW and final BW as well as greater ADG and ADFI of pigs fed with 30% DDGS for all periods. The G:F response was maximized when an SID Val:Lys ratio of 70% was provided from day 0 to 14 while an SID Val:Lys ratio of 75% maximized G:F from day 14 to 28 and for the cumulative period. The SID Val:Lys requirement was estimated at 66.6% (95% CI [65.9, 67.4]), 65.7 (95% CI: [64.8, 66.5]), and 68.4% (95% CI [66.0, 70.8]) for ADG, ADFI, and G:F, respectively, using the straight broken line (SBL) method and 69.9% (95% CI [68.2, 71.5]), 67.6 (95% CI [65.4, 69.8]), and 72.8% (95% CI [69.8, 75.8]) for the quadratic broken line (QBL) method. Pigs fed the corn\u2013SBM diet had heavier 14-d BW, final BW, and greater ADG, ADFI, G:F (P \u2264 0.032) compared to pigs fed diets containing 30% DDGS, except for cumulative ADFI compared to pigs receiving 75% SID Val:Lys (P = 0.167). In conclusion, these results suggest that when feeding 30% DDGS during the growing period, an SID Val:Lys ratio of 68% would yield more than 99% and 97% of the maximum ADG and G:F response for the 39 to 68 kg pigs. However, growth performance of pigs fed diets containing 30% DDGS did not equate to pigs consuming the corn\u2013SBM diet regardless of the SID Val:Lys ratio.<\/jats:p>","DOI":"10.1093\/jas\/skac228","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T15:51:31Z","timestamp":1656172291000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of increasing standardized ileal digestible valine: lysine in diets containing 30% dried distiller grains with solubles on growing pig performance"],"prefix":"10.1093","volume":"100","author":[{"given":"David A","family":"Clizer","sequence":"first","affiliation":[{"name":"Christensen Farms , Sleepy Eye, MN 56085 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair J","family":"Tostenson","sequence":"additional","affiliation":[{"name":"Christensen Farms , Sleepy Eye, MN 56085 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam K","family":"Tauer","sequence":"additional","affiliation":[{"name":"Christensen Farms , Sleepy Eye, MN 56085 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2257-8762","authenticated-orcid":false,"given":"Ryan S","family":"Samuel","sequence":"additional","affiliation":[{"name":"Department of Animal Science, South Dakota State University , Brookings, SD 57007 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Cline","sequence":"additional","affiliation":[{"name":"Christensen Farms , Sleepy Eye, MN 56085 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"2023062504252097600_CIT0001","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.anifeedsci.2010.06.009","article-title":"The effect of feeding wheat distillers dried grain with solubles on growth performance and nutrient digestibility in weaned pigs","volume":"160","author":"Avelar","year":"2010","journal-title":"Anim. Feed Sci. Technol"},{"key":"2023062504252097600_CIT0002","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2527\/jas.2008-1006","article-title":"The standardized ileal digestible valine-to-lysine requirement ratio is at least seventy percent in postweaned piglets","volume":"87","author":"Barea","year":"2009","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0003","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2527\/jas.2007-0834","article-title":"Response to dietary digestible energy concentration in growing pigs fed cereal grain-based diets","volume":"87","author":"Beaulieu","year":"2009","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0004","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/jas\/skz118","article-title":"Meta-regression analysis to predict the influence of branched-chain and large neutral amino acids on growth performance of pigs","volume":"97","author":"Cemin","year":"2019","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-020-00474-x","article-title":"Estimate of the energy value of soybean meal relative to corn based on growth performance of nursery pigs","volume":"11","author":"Cemin","year":"2020","journal-title":"J. Anim. Sci. Biotechnol"},{"issue":"4","key":"2023062504252097600_CIT0006","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2527\/tas2017.0049","article-title":"Modeling the effects of standardized ileal digestible valine to lysine ratio on growth performance of nursery pigs.","volume":"1","author":"Clark","year":"2017","journal-title":"Trans. J. Anim. Sci"},{"key":"2023062504252097600_CIT0007","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1126\/science.1124147","article-title":"Hypothalamic mTOR signaling regulates food intake","volume":"312","author":"Cota","year":"2006","journal-title":"Science"},{"key":"2023062504252097600_CIT0008","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2527\/jas.2014-7895","article-title":"Effects of adding supplemental tallow to diets containing 30% distillers dried grains with solubles on growth performance, carcass characteristics, and pork fat quality in growing\u2013finishing pigs","volume":"93","author":"Davis","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0009","first-page":"113","article-title":"Biological and physiological effects of deoxynivalenol (DON) in the pig.","volume-title":"Mycotoxins in farm animals","author":"Etienne","year":"2008"},{"key":"2023062504252097600_CIT0010","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.2527\/2003.8161529x","article-title":"Growth, carcass traits, and plasma amino acid concentrations of gilts fed low-protein diets supplemented with amino acids including histidine, isoleucine, and valine","volume":"81","author":"Figueroa","year":"2003","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0011","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.2527\/jas.2016-0663","article-title":"The progression of deoxynivalenol-induced growth suppression in nursery pigs and the potential of an algae-modified montmorillonite clay to mitigate these effects","volume":"94","author":"Frobose","year":"2016","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0012","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.2527\/jas.2013-6883","article-title":"The effects of deoxynivalenol-contaminated corn dried distillers grains with solubles in nursery pig diets and potential for mitigation by commercially available feed additives","volume":"93","author":"Frobose","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0013","doi-asserted-by":"crossref","first-page":"736","DOI":"10.2527\/jas.2010-3134","article-title":"Estimation of the standardized ileal digestible valine-to-lysine ratio in 13-to 32-kilogram pigs","volume":"89","author":"Gaines","year":"2011","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0014","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jat.3083","article-title":"Impacts of the feed contaminant deoxynivalenol on the intestine of monogastric animals: poultry and swine","volume":"35","author":"Ghareeb","year":"2015","journal-title":"J. Appl. Toxicol"},{"key":"2023062504252097600_CIT0015","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1017\/S1751731111000760","article-title":"Response of piglets to the valine content in diet in combination with the supply of other branched-chain amino acids","volume":"5","author":"Gloaguen","year":"2011","journal-title":"Animal"},{"key":"2023062504252097600_CIT0016","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.2527\/jas.2011-4956","article-title":"Providing a diet deficient in valine but with excess leucine results in a rapid decrease in feed intake and modifies the postprandial plasma amino acid and \u03b1-keto acid concentrations in pigs","volume":"90","author":"Gloaguen","year":"2012","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0017","first-page":"591","article-title":"Standardized ileal digestible valine: lysine dose response effects in 25-to 45-kg pigs under commercial conditions","volume":"96","author":"Gon\u00e7alves","year":"2018","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0018","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1146\/annurev.nu.04.070184.002205","article-title":"Branched-chain amino acid metabolism","volume":"4","author":"Harper","year":"1984","journal-title":"Annu. Rev. Nutr"},{"key":"2023062504252097600_CIT0019","doi-asserted-by":"crossref","first-page":"1527S","DOI":"10.1093\/jn\/135.6.1527S","article-title":"Overview of the molecular and biochemical basis of branched-chain amino acid catabolism","volume":"135","author":"Harris","year":"2005","journal-title":"J. Nutr"},{"key":"2023062504252097600_CIT0020","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.2527\/jas.2013-6934","article-title":"Determining the optimal isoleucine: lysine ratio for ten-to twenty-two-kilogram and twenty-four-to thirty-nine-kilogram pigs fed diets containing nonexcess levels of leucine","volume":"92","author":"Htoo","year":"2014","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0021","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1017\/S1751731111001844","article-title":"Feed ingredients differing in fermentable fibre and indigestible protein content affect fermentation metabolites and faecal nitrogen excretion in growing pigs","volume":"6","author":"Jha","year":"2012","journal-title":"Animal"},{"key":"2023062504252097600_CIT0022","doi-asserted-by":"crossref","first-page":"skab006","DOI":"10.1093\/jas\/skab006","article-title":"Improving performance of finishing pigs with added valine, isoleucine, and tryptophan: validating a meta-analysis model","volume":"99","author":"Kerkaert","year":"2021","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0023","doi-asserted-by":"crossref","first-page":"skaa346","DOI":"10.1093\/jas\/skaa346","article-title":"Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine","volume":"98","author":"Kwon","year":"2020","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0024","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1093\/jas\/skz259","article-title":"Excess dietary leucine in diets for growing pigs reduces growth performance, biological value of protein, protein retention, and serotonin synthesis","volume":"97","author":"Kwon","year":"2019","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0025","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.2527\/jas.2015-9308","article-title":"Estimation of the standardized ileal digestible valine to lysine ratio required for 25- to 120-kilogram pigs fed low crude protein diets supplemented with crystalline amino acids","volume":"93","author":"Liu","year":"2015","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40104-021-00565-3","article-title":"Phenolic compounds as natural feed additives in poultry and swine diets: a review","volume":"12","author":"Mahfuz","year":"2021","journal-title":"J. Anim. Sci. Biotechnol"},{"key":"2023062504252097600_CIT0027","volume-title":"Analysis of messy data: designed experiments","author":"Milliken","year":"2009","edition":"2"},{"key":"2023062504252097600_CIT0028","volume-title":"Nutrient requirements of swine","author":"NRC.","year":"2012","edition":"11"},{"key":"2023062504252097600_CIT0029","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4141\/A04-001","article-title":"Voluntary feed intake in growing-finishing pigs: a review of the main determining factors and potential approaches for accurate predictions","volume":"84","author":"Nyachoti","year":"2004","journal-title":"Can. J. Anim. Sci"},{"issue":"2","key":"2023062504252097600_CIT0030","doi-asserted-by":"crossref","first-page":"620","DOI":"10.2527\/jas.2013-6238","article-title":"Evaluation of two mycotoxin mitigation strategies in grow-finish swine diets containing corn dried distillers grains with solubles naturally contaminated with deoxynivalenol","volume":"92","author":"Patience","year":"2014","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0031","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.anifeedsci.2014.07.011","article-title":"Compositional profile and variation of distillers dried grains with solubles from various origins with focus on non-starch polysaccharides","volume":"197","author":"Pedersen","year":"2014","journal-title":"Anim. Feed Sci. Technol"},{"key":"2023062504252097600_CIT0032","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.anifeedsci.2007.06.006","article-title":"Deoxynivalenol: toxicity, mechanisms and animal health risks","volume":"137","author":"Pestka","year":"2007","journal-title":"Anim. Feed Sci. Technol"},{"key":"2023062504252097600_CIT0033","volume-title":"Nutrient specifications manual","author":"PIC.","year":"2016"},{"key":"2023062504252097600_CIT0034","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/jas\/sky036","article-title":"Immunomodulatory potential of dietary soybean-derived isoflavones and saponins in pigs","volume":"96","author":"Smith","year":"2018","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0035","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1017\/S1751731115000695","article-title":"Requirement of standardized ileal digestible valine to lysine ratio for 8-to 14-kg pigs","volume":"9","author":"Soumeh","year":"2015","journal-title":"Animal"},{"key":"2023062504252097600_CIT0036","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.2527\/jas.2008-1290","article-title":"BOARD-INVITED REVIEW: The use and application of distillers dried grains with solubles in swine diets","volume":"87","author":"Stein","year":"2009","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0037","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3920\/978-90-8686-781-3_119","article-title":"Meta-analysis of the response of growing pigs to valine content of the diet.","volume-title":"Energy and protein metabolism and nutrition in sustainable animal production No. 134","author":"Van Milgen","year":"2013"},{"issue":"7","key":"2023062504252097600_CIT0038","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.2527\/jas.2011-4454","article-title":"Valine and isoleucine requirement of 20-to 45-kilogram pigs","volume":"90","author":"Waguespack","year":"2012","journal-title":"J. Anim. Sci"},{"key":"2023062504252097600_CIT0039","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1017\/S0007114509992212","article-title":"The effects of branched-chain amino acid interactions on growth performance, blood metabolites, enzyme kinetics and transcriptomics in weaned pigs","volume":"103","author":"Wiltafsky","year":"2010","journal-title":"Br. J. Nutr"},{"key":"2023062504252097600_CIT0040","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.2527\/jas.2008-1221","article-title":"Estimates of the optimum dietary ratio of standardized ileal digestible valine to lysine for eight to twenty-five kilograms of body weight pigs","volume":"87","author":"Wiltafsky","year":"2009","journal-title":"J. Anim. Sci"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skac228\/44251579\/skac228.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/100\/9\/skac228\/45908594\/skac228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/100\/9\/skac228\/45908594\/skac228.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T04:27:44Z","timestamp":1687667264000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skac228\/6618016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jas\/skac228","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2022,6,25]]},"article-number":"skac228"}}