{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:12:12Z","timestamp":1785337932417,"version":"3.55.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32172932"],"award-info":[{"award-number":["32172932"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Program of Natural Science Foundation of Heilongjiang Province of China","award":["ZD2021C003"],"award-info":[{"award-number":["ZD2021C003"]}]},{"name":"China Agriculture Research System","award":["CARS-35"],"award-info":[{"award-number":["CARS-35"]}]},{"name":"China Agriculture Research System","award":["T201908"],"award-info":[{"award-number":["T201908"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of the present study was to investigate the effects of drinking water alkaline mineral complex (AMC) supplementation on growth performance, intestinal morphology, inflammatory response, immunity, antioxidant defense system, and barrier functions in weaned piglets. In a 15-d trial, 240 weaned piglets (9.35 \u00b1 0.86 kg) at 28 d of age (large white \u00d7 landrace \u00d7 Duroc) were randomly divided into two groups: the control (Con) group and the AMC group. Drinking water AMC supplementation improved (P &amp;lt; 0.01) final body weight (BW) and average daily gain (ADG) in weaned piglets compared to the Con group. Importantly, AMC reduced (P &amp;lt; 0.01) the feed-to-gain (F:G) ratio. AMC water improved the physical health conditions of piglets under weaning stress, as reflected by the decreased (P &amp;lt; 0.05) hair score and conjunctival score. Moreover, there was no significant (P &amp;gt; 0.05) difference in relatively small intestinal length, organ (liver, spleen, and kidney) indices, or gastrointestinal pH value in weaned piglets between the two groups. Of note, AMC significantly promoted the microvilli numbers in the small intestine and effectively ameliorated the gut morphology damage induced by weaning stress, as evidenced by the increased (P &amp;lt; 0.05) villous height (VH) and ratio of VH to crypt depth. Additionally, AMC lessened the levels of lipopolysaccharide (LPS, P &amp;lt; 0.01) and the contents of IL1\u03b2 (P&amp;lt;0.05), and TNF-\u03b1 (P&amp;lt;0.05) in the weaned piglet small intestine. Conversely, the gut immune barrier marker, secretory immunoglobulin A (sIgA) levels in serum and small intestine mucosa were elevated after AMC water treatment (P &amp;lt; 0.01). Furthermore, AMC elevated the antioxidant mRNA levels of (P &amp;lt; 0.05) SOD 1-2, (P &amp;lt; 0.01) CAT, and (P &amp;lt; 0.01) GPX 1-2 in the small intestine. Likewise, the mRNA levels of the small intestine tight junction factors Occludin (P &amp;lt; 0.01), ZO-1 (P &amp;lt; 0.05), Claudin 2 (P &amp;lt; 0.01), and Claudin 5 (P&amp;lt;0.01) in the AMC treatment group were notably higher than those in the Con group. In conclusion, drinking water AMC supplementation has an accelerative effect on growth performance by elevating gut health by improving intestinal morphology, the inflammatory response, the antioxidant defense system, and barrier function in weaned piglets.<\/jats:p>","DOI":"10.1093\/jas\/skac251","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T16:40:21Z","timestamp":1659372021000},"source":"Crossref","is-referenced-by-count":24,"title":["Effects of alkaline mineral complex water supplementation on growth performance, inflammatory response, and intestinal barrier function in weaned piglets"],"prefix":"10.1093","volume":"100","author":[{"given":"Jian","family":"Chen","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Northeast Agricultural University , Harbin 150030 , P.R. 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