{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T14:27:32Z","timestamp":1784903252491,"version":"3.55.0"},"reference-count":107,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three experiments (EXP) were conducted to determine the effect of feed additives on performance, intestinal integrity, gastrointestinal volatile fatty acids (VFA), and energy and nutrient digestion in nonchallenged nursery pigs. In EXP 1, 480 pigs (6.36-kg body weight, BW) were placed into 96 pens with 5 pigs\/pen, and allotted to 1 of 10 dietary treatments: 1) negative control containing no feed additive (NC), 2) NC\u2005+\u200544 mg chlortetracycline and 38.5 mg tiamulin\/kg diet (CTsb), 3) NC\u2005+\u20055% resistant potato starch (RSpo), 4) NC\u2005+\u20055% soluble corn fiber (SCF), 5) NC\u2005+\u20055% sugar beet pulp (SBP), 6) NC\u2005+\u20050.30% fatty acid mix (FAM), 7) NC\u2005+\u20050.10% phytogenic blend of essential oils and flavoring compounds (PHY), 8) NC\u2005+\u200550 mg Cu and 1,600 mg zinc oxide\/kg diet (CuZn), 9) NC\u2005+\u20055% resistant corn starch (RScn), and 10) NC\u2005+\u20050.05% \u03b2-glucan (BG) for 28 d. There was no impact of dietary treatment on BW gain or feed intake (P\u2005\u2265\u20050.22). Pigs fed diets containing SCF, CTsb, and RSpo resulted in microbial community differences compared to pigs fed the NC (P\u2005&amp;lt;\u20050.05). In EXP 2, 48 barrows (12.8 kg BW) were selected at the end of EXP 1 and fed the same dietary treatments they had previously received: 1) NC, 2) NC\u2005+\u20055% RScn, 3) NC\u2005+\u20055% SCF, and 4) NC\u2005+\u2005FAM for 8 d. There was no effect of feeding diets containing RScn, SCF, or FAM on in vivo intestinal permeability (P\u2005\u2264\u20050.21). Ileal or colon pH, concentrations of VFA did not differ due to dietary treatment (P\u2005\u2265\u20050.36), but pigs fed diets containing FAM resulted in a greater butyric acid concentration in the cecum compared to pigs fed the NC (P\u2005\u2264\u20050.05). In EXP 3, 156 pigs (6.11 kg BW) were placed into 52 pens with 3 pigs\/pen and allotted to 1 of 4 dietary treatments arranged in a factorial manner: 1) NC, 2) NC\u2005+\u20055% RSpo, 3) NC\u2005+\u20050.30% FAM, and 4) NC\u2005+\u20055% RSpo\u2005+\u20050.30% FAM for 24 d. Feeding pigs diets containing RSpo did not affect BW gain (P\u2005=\u20050.91) while pigs fed diets containing FAM grew improved BW gain (P\u2005=\u20050.09). Colonic butyric acid concentrations were greater in pigs fed diets containing RSpo (P\u2005=\u20050.03), while pigs fed diets containing FAM exhibited reduced total VFA concentrations (P\u2005=\u20050.11). The results indicate that supplementing diets with digestively resistant but fermentable fibers, short- and medium-chain fatty acids, or antibiotics do not have a consistent effect, positive or negative, on markers of intestinal integrity or barrier function, intestinal VFA patterns, ATTD of energy and nutrients, or on pig performance.<\/jats:p>","DOI":"10.1093\/jas\/skac282","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T21:28:06Z","timestamp":1663795686000},"source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of digestively resistant or soluble fibers, short- and medium-chain fatty acids, trace minerals, and antibiotics in nonchallenged nursery pigs on performance, digestibility, and intestinal integrity"],"prefix":"10.1093","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3123-8615","authenticated-orcid":false,"given":"Brian J","family":"Kerr","sequence":"first","affiliation":[{"name":"USDA-ARS-National Laboratory for Agriculture and the Environment , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian M","family":"Trachsel","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Animal Disease Center , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley L","family":"Bearson","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Laboratory for Agriculture and the Environment , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal L","family":"Loving","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Animal Disease Center , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn M D","family":"Bearson","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Animal Disease Center , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen A","family":"Byrne","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Animal Disease Center , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C","family":"Pearce","sequence":"additional","affiliation":[{"name":"USDA-ARS-National Laboratory for Agriculture and the Environment , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby M","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science and Education , Oak Ridge, TN 37831 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7283-4782","authenticated-orcid":false,"given":"Nicholas K","family":"Gabler","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University $ , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley P","family":"Schweer","sequence":"additional","affiliation":[{"name":"Zinpro Corporation , Eden Prairie, MN 55344 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-9690","authenticated-orcid":false,"given":"Emma T","family":"Helm","sequence":"additional","affiliation":[{"name":"Virginia Tech, Blacksburg , VA 24061 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson M","family":"De Mille","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Iowa State University , Ames, IA 50011 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"2022111715092692600_CIT0001","first-page":"903","article-title":"Digestion and balance techniques in pigs.","volume-title":"Swine nutrition","author":"Adeola","year":"2001","edition":"2"},{"key":"2022111715092692600_CIT0002","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.tim.2012.11.001","article-title":"Treatment, promotion, commotion: antibiotic alternatives in food-producing animals","volume":"21","author":"Allen","year":"2013","journal-title":"Trends Microbiol"},{"key":"2022111715092692600_CIT0003","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fmicb.2010.00134","article-title":"A brief history of the antibiotic era: lessons learned and challenges for the future","volume":"1","author":"Aminov","year":"2010","journal-title":"Frontiers Micro"},{"key":"2022111715092692600_CIT0004","volume-title":"Official Methods of Analysis","author":"AOAC Int","year":"1978","edition":"9"},{"key":"2022111715092692600_CIT0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1079\/NRR2006123","article-title":"Influence of dietary components on development of the microbiota in single-stomached species","volume":"19","author":"Bauer","year":"2006","journal-title":"Nutr. 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