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Here, reproductive parameters and gene expression changes in ovaries and endometrium were explored on day 6 after artificial insemination (AI), when synthetic progestin altrenogest (ALT) was combined with gonadotropins. Sows were administered ALT for 7 d beginning on the day of weaning and superovulated with equine chorionic gonadotropin (eCG) 24 h later and human chorionic gonadotropins (hCG) at the onset of estrus (SS-7 group; n = 6). The controls were either superovulated sows with eCG 24 h postweaning and hCG at the onset of estrus (SC group; n = 6) or sows with postweaning spontaneous estrus (NC group; n = 6). Ovary examination and embryo and tissue collection were performed in all sows via laparotomy on day 6 post-AI. RNA-Seq was conducted to analyze differentially expressed genes (DEGs) between groups. Statistical analysis of the reproductive parameters was conducted with ANOVA and Tukey post hoc tests. DEGs were analyzed with an ANOVA (fold changes \u22652 or \u22642, P value &amp;lt;0.05). Hormonal treatments almost doubled (P &amp;lt; 0.03) the number of corpora lutea (39.8 \u00b1 10.2 and 38.3 \u00b1 11.1 in SS-7 and SC sows, respectively) compared with that in the NC group (23.1 \u00b1 3.8). In contrast, embryo viability significantly decreased (P &amp;lt; 0.003) in response to SS-7 treatment (75.1% \u00b1 15.2%) compared to SC and NC groups (93.8 \u00b1 7.6% and 91.8 \u00b1 6.9%, respectively). RNA-Seq analyses revealed 675 and 1,583 DEGs in the SS-7 group compared to both SC and NC groups in endometrial and ovarian samples, respectively. Interestingly, many genes with key roles in the Wnt\/\u03b2-catenin and Notch signaling pathways were differentially expressed in SS-7 sows relative to SC and NC groups (e.g., Ctnnb1, Myc, Gli3, Scyl2, Ccny, Daam1, Ppm1n, Rbpj, and Usp8). A key finding in this study was the downregulation of \u03b2-catenin (Ctnnb1) gene expression in the SS-7 endometrium, suggesting that this treatment influences embryo\u2013uterine dialogue by triggering a cascade of events leading to embryo maldevelopment. These data explain the proliferative defects in SS-7 embryos and suggest a novel mechanism of a porcine embryo\u2013maternal crosstalk.<\/jats:p>","DOI":"10.1093\/jas\/skac315","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T14:58:41Z","timestamp":1664377121000},"source":"Crossref","is-referenced-by-count":11,"title":["Combined synchronization and superovulation treatments negatively impact embryo viability possibly by the downregulation of WNT\/\u03b2-catenin and Notch signaling genes in the porcine endometrium"],"prefix":"10.1093","volume":"100","author":[{"given":"Henar","family":"Gonzalez-Ramiro","sequence":"first","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Parrilla","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Miquel Cambra","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gonzalez-Plaza","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Antonia Gil","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cuello","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio A","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Medicine and Animal Surgery, Faculty of Veterinary Medicine, University of Murcia , Murcia 30100 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynaecology, Link\u00f6ping University , Link\u00f6ping 58225 , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-0191","authenticated-orcid":false,"given":"Cristina A","family":"Martinez","sequence":"additional","affiliation":[{"name":"Department of Biomedical & Clinical Sciences (BKV), BKH\/Obstetrics & Gynaecology, Link\u00f6ping University , Link\u00f6ping 58225 , Sweden"},{"name":"Department of Animal Reproduction, National Institute for Agriculture and Food Research and Technology (INIA) , Madrid 28006 , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2022112317030190100_CIT0001","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.theriogenology.2013.12.017","article-title":"The effects of superovulation of donor sows on ovarian response and embryo development after nonsurgical deep-uterine embryo transfer","volume":"81","author":"Angel","year":"2014","journal-title":"Theriogenology"},{"key":"2022112317030190100_CIT0002","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"2022112317030190100_CIT0003","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.mod.2005.06.005","article-title":"Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling","volume":"122","author":"Barsi","year":"2005","journal-title":"Mech. 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