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A total of 192 male broilers (28-d old) were randomly allocated to four groups. A chronic HS model (at a temperature of 32 \u00b0C and 50%\u201360% relative humidity for 24 h daily) was applied in the experiment. Normal control (NC, ad libitum feeding, 22 \u00b0C), HS group (HS, ad libitum feeding, 32 \u00b0C), pair-fed group (PF, received food equivalent to that consumed by the HS group on the previous day, 22 \u00b0C), guanidinoacetic acid group (HG, ad libitum feeding, supplementing the basal diet with 0.6 g\/kg GAA, 32 \u00b0C). The experiment lasted from 28 to 35 and 28 to 42 d of age of broilers. Our results showed that broilers subjected to HS had lower average daily feed intake and average daily gain (P\u2005&amp;lt;\u20050.05), higher feed-to-gain ratio and relative length of the small intestine (P\u2005&amp;lt;\u20050.05), as well as lower relative weight and weight per unit length of the small intestine (P\u2005&amp;lt;\u20050.05). HS damaged the small intestinal histomorphology by decreasing the small intestinal VH and the VH\/CD (P\u2005&amp;lt;\u20050.05). Compared with the HS group, supplementation with 0.6 g\/kg GAA increased jejunal VH and VH\/CD (P\u2005&amp;lt;\u20050.05), but decreased relative weight and relative length of the small intestine (P\u2005&amp;lt;\u20050.05). Moreover, in comparison with NC, HS elevated intestinal permeability (D-Lactic acid concentration and diamine oxidase activity) and mRNA expression levels of interleukin-1\u03b2, interleukin-6, and tumor necrosis factor-\u03b1 (P\u2005&amp;lt;\u20050.05), reduced jejunal mucus thickness, number of goblet cells, IgA\u2005+\u2005cell density, and mucin2 mRNA expression level of broilers (P\u2005&amp;lt;\u20050.05). Compared with the HS group, dietary GAA elevated jejunal mucus thickness, goblet cell number and IgA+ cell density (P\u2005&amp;lt;\u20050.05), and up-regulated jejunal mRNA expression of interleukin-1\u03b2 and tumor necrosis factor-\u03b1 (P\u2005&amp;lt;\u20050.05). In conclusion, HS impaired growth performance, and the intestinal mucosal barrier function of broilers. Dietary supplementation with 0.6 g\/kg GAA alleviated HS-induced histomorphology changes of small intestine and jejunal mucosal barrier dysfunction.<\/jats:p>","DOI":"10.1093\/jas\/skac355","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T19:28:06Z","timestamp":1666726086000},"source":"Crossref","is-referenced-by-count":34,"title":["Guanidinoacetic acid supplementation improves intestinal morphology, mucosal barrier function of broilers subjected to chronic heat stress"],"prefix":"10.1093","volume":"101","author":[{"given":"Xu Y","family":"Peng","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University , Nanjing 210095 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1561-4614","authenticated-orcid":false,"given":"Tong","family":"Xing","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University , Nanjing 210095 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao L","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Agricultural Products Processing, Jiangsu Academy of Agricultural Sciences , Nanjing 210014 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1555-1086","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University , Nanjing 210095 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Food Science and Pharmaceutical Engineering, Nanjing Normal University , Nanjing 210023 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Key Laboratory of Animal Origin Food Production and Safety Guarantee of Jiangsu Province, Jiangsu Collaborative Innovation Center of Meat Production and Processing, Quality and Safety Control, Nanjing Agricultural University , Nanjing 210095 , People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,25]]},"reference":[{"key":"2023030119032634900_","doi-asserted-by":"crossref","first-page":"101337","DOI":"10.1016\/j.psj.2021.101337","article-title":"Protective influence of betaine on intestinal health by regulating inflammation and improving barrier function in broilers under heat stress","volume":"100","author":"Alhotan","year":"2021","journal-title":"Poult Sci"},{"key":"2023030119032634900_","doi-asserted-by":"crossref","first-page":"114208","DOI":"10.1016\/j.anifeedsci.2019.114208","article-title":"Efficacy of guanidinoacetic acid at different dietary crude protein levels on growth performance, stress indicators, antioxidant status, and intestinal morphology in broiler chickens subjected to cyclic heat stress","volume":"254","author":"Amiri","year":"2019","journal-title":"Anim. 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