{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:34:03Z","timestamp":1783182843892,"version":"3.54.6"},"reference-count":45,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T00:00:00Z","timestamp":1669593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31601973"],"award-info":[{"award-number":["31601973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"College student innovation and entrepreneurship training program in Nanjing Agriculture University","award":["S20190014"],"award-info":[{"award-number":["S20190014"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The present study was carried out to investigate the effects of bamboo leaf extract (BLE) on energy metabolism, antioxidant capacity, and biogenesis of broilers\u2019 small intestine mitochondria. A total of 384 one-day-old male Arbor Acres broiler chicks were randomly divided into four groups with six replicates each for 42 d. The control group was fed a basal diet, whereas the BLE1, BLE2, and BLE3 groups consumed basal diets with 1.0, 2.0, and 4.0 g\/kg of BLE, respectively. Some markers of mitochondrial energy metabolism including isocitrate dehydrogenase, \u03b1-ketoglutarate dehydrogenase, and malate dehydrogenase and some markers of redox system including total superoxide dismutase, malondialdehyde, and glutathione were measured by commercial colorimetric kits. Mitochondrial and cellular antioxidant genes, mitochondrial biogenesis-related genes, and mitochondrial DNA copy number were measured by quantitative real-time-polymerase chain reaction (qRT-PCR). Data were analyzed using the SPSS 19.0, and differences were considered as significant at P &amp;lt; 0.05. BLE supplementation linearly increased jejunal mitochondrial isocitrate dehydrogenase (P &amp;lt; 0.05) and total superoxide dismutase (P &amp;lt; 0.05) activity. The ileal manganese superoxide dismutase mRNA expression was linearly affected by increased dietary BLE supplementation (P &amp;lt; 0.05). Increasing BLE supplementation linearly increased jejunal sirtuin 1 (P &amp;lt; 0.05) and nuclear respiratory factor 1 (P &amp;lt; 0.05) mRNA expression. Linear (P &amp;lt; 0.05) and quadratic (P &amp;lt; 0.05) responses of the ileal nuclear respiratory factor 2 mRNA expression occurred with increased dietary BLE levels. In conclusion, BLE supplementation was beneficial to the energy metabolism, antioxidant capacity, and biogenesis of small intestine mitochondria in broilers. The dose of 4.0 g\/kg BLE demonstrated the best effects.<\/jats:p>","DOI":"10.1093\/jas\/skac391","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T09:50:14Z","timestamp":1669629014000},"source":"Crossref","is-referenced-by-count":8,"title":["Effects of bamboo leaf extract on energy metabolism, antioxidant capacity, and biogenesis of small intestine mitochondria in broilers"],"prefix":"10.1093","volume":"101","author":[{"given":"Zechen","family":"Xie","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yun","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9038-5009","authenticated-orcid":false,"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Nanjing Agriculture University , Nanjing, Jiangsu 210095 , P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"2023112010572829200_CIT0001","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20110162","article-title":"Assessing mitochondrial dysfunction in cells","volume":"435","author":"Brand","year":"2011","journal-title":"Biochem. J."},{"key":"2023112010572829200_CIT0002","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.euroneuro.2010.10.007","article-title":"Abnormalities in the tricarboxylic acid (TCA) cycle in the brains of schizophrenia patients","volume":"21","author":"Bubber","year":"2011","journal-title":"Eur. Neuropsychopharmacol."},{"key":"2023112010572829200_CIT0003","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.psj.2019.10.025","article-title":"Dietary beta-sitosterol regulates serum lipid level and improves immune function, antioxidant status, and intestinal morphology in broilers","volume":"99","author":"Cheng","year":"2020","journal-title":"Poult. Sci."},{"key":"2023112010572829200_CIT0004","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.tem.2020.02.011","article-title":"Polyphenols as caloric restriction mimetics regulating mitochondrial biogenesis and mitophagy","volume":"31","author":"Davinelli","year":"2020","journal-title":"Trends Endocrinol. Metab."},{"key":"2023112010572829200_CIT0005","doi-asserted-by":"crossref","first-page":"5923938","DOI":"10.1155\/2016\/5923938","article-title":"Mitochondrial alterations in peripheral mononuclear blood cells from Alzheimer\u2019s disease and mild cognitive impairment patients","volume":"2016","author":"Delbarba","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2023112010572829200_CIT0006","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.pbi.2004.03.007","article-title":"Respiratory metabolism: glycolysis, the TCA cycle and mitochondrial electron transport","volume":"7","author":"Fernie","year":"2004","journal-title":"Curr. Opin Plant Biol."},{"key":"2023112010572829200_CIT0007","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.3390\/molecules26154682","article-title":"Effect of methyl jasmonate on the terpene trilactones, flavonoids, and phenolic acids in Ginkgo biloba l. leaves: relevance to leaf senescence","volume":"26","author":"Horbowicz","year":"2021","journal-title":"Molecules."},{"key":"2023112010572829200_CIT0008","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1021\/jf0001637","article-title":"Evaluation of antioxidant and prooxidant activities of bamboo Phyllostachys nigra var. Henonis leaf extract in vitro","volume":"48","author":"Hu","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"2023112010572829200_CIT0009","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.3390\/ani10071239","article-title":"Piceatannol ameliorates hepatic oxidative damage and mitochondrial dysfunction of weaned piglets challenged with diquat","volume":"10","author":"Jia","year":"2020","journal-title":"Animals."},{"key":"2023112010572829200_CIT0010","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3390\/antiox8120575","article-title":"Dietary stevioside supplementation alleviates lipopolysaccharide-induced intestinal mucosal damage through anti-inflammatory and antioxidant effects in broiler chickens","volume":"8","author":"Jiang","year":"2019","journal-title":"Antioxidants."},{"key":"2023112010572829200_CIT0011","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.psj.2020.10.013","article-title":"Genistein activated adenosine 5\u2019-monophosphate-activated protein kinase-sirtuin1\/peroxisome proliferator-activated receptor \u03b3 coactivator-1\u03b1 pathway potentially through adiponectin and estrogen receptor \u03b2 signaling to suppress fat deposition in broiler chickens","volume":"100","author":"Jiang","year":"2021","journal-title":"Poult. Sci."},{"key":"2023112010572829200_CIT0012","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.3390\/molecules25133060","article-title":"Flavonoids and mitochondria: activation of cytoprotective pathways?","volume":"25","author":"Kicinska","year":"2020","journal-title":"Molecules."},{"key":"2023112010572829200_CIT0013","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jep.2010.08.062","article-title":"The effect of bamboo extract on hepatic biotransforming enzymes--findings from an obese-diabetic mouse model","volume":"133","author":"Koide","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"2023112010572829200_CIT0014","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.3168\/jds.2015-9847","article-title":"Mitochondrial DNA copy number and biogenesis in different tissues of early- and late-lactating dairy cows","volume":"99","author":"Laubenthal","year":"2016","journal-title":"J. Dairy Sci."},{"key":"2023112010572829200_CIT0015","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.5713\/ab.20.0527","article-title":"Effects of bamboo leaf extract on the production performance, rumen fermentation parameters, and rumen bacterial communities of heat-stressed dairy cows","volume":"34","author":"Li","year":"2021","journal-title":"Anim. Biosci."},{"key":"2023112010572829200_CIT0016","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1631\/jzus.B1400249","article-title":"Bamboo leaf extract improves spatial learning ability in a rat model with senile dementia","volume":"16","author":"Liu","year":"2015","journal-title":"J. Zhejiang Univ. Sci. B."},{"key":"2023112010572829200_CIT0017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"2023112010572829200_CIT0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijbiomac.2012.12.027","article-title":"In vitro antioxidant activities of polysaccharides extracted from Moso \u00adBamboo-Leaf","volume":"55","author":"Mao","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"2023112010572829200_CIT0019","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0009-9120(99)00075-2","article-title":"Antioxidant enzymes and human diseases","volume":"32","author":"Mat\u00e9s","year":"1999","journal-title":"Clin. Biochem."},{"key":"2023112010572829200_CIT0020","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3389\/fvets.2019.00060","article-title":"Oxidative stress in the poultry gut: potential challenges and interventions","volume":"6","author":"Mishra","year":"2019","journal-title":"Front. Vet. Sci."},{"key":"2023112010572829200_CIT0021","volume-title":"Nutrient requirements of poultry.","author":"National Research Council.","year":"1994","edition":"9th rev. ed."},{"key":"2023112010572829200_CIT0022","doi-asserted-by":"crossref","first-page":"e12627","DOI":"10.1111\/jpi.12627","article-title":"Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos","volume":"68","author":"Niu","year":"2020","journal-title":"J. Pineal Res."},{"key":"2023112010572829200_CIT0023","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3382\/ps\/pew313","article-title":"Effect of supplemental fermented Ginkgo biloba leaves at different levels on growth performance, meat quality, and antioxidant status of breast and thigh muscles in broiler chickens","volume":"96","author":"Niu","year":"2017","journal-title":"Poult. Sci."},{"key":"2023112010572829200_CIT0024","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.cbpa.2007.02.029","article-title":"Membrane potential and H2O2 production in duodenal mitochondria from broiler chickens (Gallus gallus domesticus) with low and high feed efficiency","volume":"147","author":"Ojano-Dirain","year":"2007","journal-title":"Comp. Biochem. Physiol. A: Mol. Integr. Physiol."},{"key":"2023112010572829200_CIT0025","doi-asserted-by":"crossref","first-page":"38388","DOI":"10.1074\/jbc.M105395200","article-title":"Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria","volume":"276","author":"Okado-Matsumoto","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2023112010572829200_CIT0026","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuro.2015.10.002","article-title":"Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1alpha signaling pathway","volume":"51","author":"Sharma","year":"2015","journal-title":"Neurotoxicology."},{"key":"2023112010572829200_CIT0027","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3390\/ani9090699","article-title":"Effect of bamboo leaf extract on antioxidant status and cholesterol metabolism in broiler chickens","volume":"9","author":"Shen","year":"2019","journal-title":"Animals."},{"key":"2023112010572829200_CIT0028","doi-asserted-by":"crossref","first-page":"6787","DOI":"10.3382\/ps\/pez404","article-title":"Effects of bamboo leaf extract on growth performance, meat quality, and meat oxidative stability in broiler chickens","volume":"98","author":"Shen","year":"2019","journal-title":"Poult. Sci."},{"key":"2023112010572829200_CIT0029","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/2331","article-title":"Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs","volume":"5","author":"Stoddard","year":"1998","journal-title":"Nat. Struct. Biol."},{"key":"2023112010572829200_CIT0030","doi-asserted-by":"crossref","first-page":"8238","DOI":"10.3390\/molecules19068238","article-title":"Biological activities and phytochemical profiles of extracts from different parts of bamboo (Phyllostachys pubescens)","volume":"19","author":"Tanaka","year":"2014","journal-title":"Molecules."},{"key":"2023112010572829200_CIT0031","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cbpb.2017.12.013","article-title":"Multidimensional mitochondrial energetics: application to the study of electron leak and hydrogen peroxide metabolism","volume":"224","author":"Treberg","year":"2018","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"2023112010572829200_CIT0032","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1365-2796.2007.01905.x","article-title":"Mitochondrial dysfunction as a cause of ageing","volume":"263","author":"Trifunovic","year":"2008","journal-title":"J. Intern. Med."},{"key":"2023112010572829200_CIT0033","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1016\/j.sjbs.2021.06.040","article-title":"Protective effects of vitexin on cadmium-induced renal toxicity in rats","volume":"28","author":"Umar Ijaz","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"2023112010572829200_CIT0034","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1073\/pnas.91.4.1309","article-title":"Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis","volume":"91","author":"Virbasius","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"2023112010572829200_CIT0035","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0047-6374(81)90087-7","article-title":"Comparison between developmental and senescent changes in enzyme activities linked to energy metabolism in rat heart","volume":"16","author":"Vitorica","year":"1981","journal-title":"Mech. Ageing Dev."},{"key":"2023112010572829200_CIT0036","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell."},{"key":"2023112010572829200_CIT0037","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1021\/acs.jafc.7b02203","article-title":"Potent anti-inflammatory and antiadipogenic properties of bamboo (Sasa coreana Nakai) leaves extract and its major constituent flavonoids","volume":"65","author":"Yang","year":"2017","journal-title":"J. Agric. Food Chem."},{"key":"2023112010572829200_CIT0038","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/j.ijbiomac.2017.03.124","article-title":"Bamboo leaf extract ameliorates diabetic nephropathy through activating the AKT signaling pathway in rats","volume":"105","author":"Ying","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"2023112010572829200_CIT0039","doi-asserted-by":"crossref","first-page":"101484","DOI":"10.1016\/j.psj.2021.101484","article-title":"Effects of trans-anethole supplementation on serum lipid metabolism parameters, carcass characteristics, meat quality, fatty acid, and amino acid profiles of breast muscle in broiler chickens","volume":"100","author":"Yu","year":"2021","journal-title":"Poult. Sci."},{"key":"2023112010572829200_CIT0040","doi-asserted-by":"crossref","first-page":"skac201","DOI":"10.1093\/jas\/skac201","article-title":"Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets","volume":"100","author":"Yu","year":"2022","journal-title":"J. Anim. Sci."},{"key":"2023112010572829200_CIT0041","doi-asserted-by":"crossref","first-page":"skab255","DOI":"10.1093\/jas\/skab255","article-title":"Effects of Bacillus subtilis on jejunal integrity, redox status, and microbial composition of intrauterine growth restriction suckling piglets","volume":"99","author":"Yun","year":"2021","journal-title":"J. Anim. Sci."},{"key":"2023112010572829200_CIT0042","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/jsfa.8576","article-title":"Effect of dietary resveratrol supplementation on meat quality, muscle antioxidative capacity and mitochondrial biogenesis of broilers","volume":"98","author":"Zhang","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"2023112010572829200_CIT0043","doi-asserted-by":"crossref","first-page":"skaa328","DOI":"10.1093\/jas\/skaa328","article-title":"Protective effects of pterostilbene against hepatic damage, redox imbalance, mitochondrial dysfunction, and endoplasmic reticulum stress in weanling piglets","volume":"98","author":"Zhang","year":"2020","journal-title":"J. Anim. Sci."},{"key":"2023112010572829200_CIT0044","doi-asserted-by":"crossref","first-page":"9927864","DOI":"10.1155\/2021\/9927864","article-title":"Bisdemethoxycurcumin protects small intestine from lipopolysaccharide-induced mitochondrial dysfunction via activating \u00admitochondrial antioxidant systems and mitochondrial biogenesis in broiler chickens","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"2023112010572829200_CIT0045","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.biopha.2017.08.138","article-title":"Bamboo leaf extract ameliorates cardiac fibrosis possibly via alleviating inflammation, oxidative stress and apoptosis","volume":"95","author":"Zhang","year":"2017","journal-title":"Biomed. Pharmacother."}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skac391\/47366428\/skac391.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skac391\/53586142\/skac391.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skac391\/53586142\/skac391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T10:58:24Z","timestamp":1700477904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skac391\/6849404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,28]]},"references-count":45,"URL":"https:\/\/doi.org\/10.1093\/jas\/skac391","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,11,28]]},"article-number":"skac391"}}