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Forty pigs (26 d of age; initial BW of 7.1\u2005\u00b1\u20050.5 kg) were allotted to 5 dietary treatments based on a randomized complete block design with sex and initial BW as blocks. Dietary treatments were supplemented with varying SID His to Lys ratios of 26%, 32%, 38%, 43%, and 49% and fed to pigs for 14 d (SID Lys\u2005=\u20051.22%). Feed intake and BW were recorded at d 0, 7, and 14 to measure growth performance. Blood samples were collected on d 12. Pigs were euthanized on d 14 to collect pancreas, longissimus dorsi muscles, mid-jejunum, and jejunal mucosa. Data were analyzed using the Proc Mixed of SAS. Growth performance was not affected, whereas varying SID His to Lys ratio affected hemoglobin (P\u2005&amp;lt;\u20050.05, max: 12 g\/dL at 36%), immunoglobulin A (IgA, P\u2005&amp;lt;\u20050.05, min: 1.25 \u03bcg\/mg at 35%) in jejunal mucosa, villus height (P\u2005=\u20050.065, max: 536 \u03bcm at 40%) in jejunum, trypsinogen (P\u2005=\u20050.083, max: 242 pg\/mg at 41%) in pancreas, and carnosine (P\u2005=\u20050.051, max: 4.7 ng\/mg at 38%) in muscles. Varying SID His to Lys ratios linearly increased (P\u2005&amp;lt;\u20050.05, from 1.95 to 2.80 nmol\/mg) protein carbonyl in muscles and decreased (P\u2005&amp;lt;\u20050.05, from 29.1% to 26.9%) enterocyte proliferation. In conclusion, SID His to Lys ratio between 35% and 41% in diets fed to nursery pigs at 7 to 11 kg enhanced intestinal health and maximized concentrations of His-containing proteins, indicating that His-containing proteins are effective response criteria when determining His requirement.<\/jats:p>","DOI":"10.1093\/jas\/skac396","type":"journal-article","created":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T14:28:54Z","timestamp":1669645734000},"source":"Crossref","is-referenced-by-count":6,"title":["The effects of standardized ileal digestible His to Lys ratio on growth performance, intestinal health, and mobilization of histidine-containing proteins in pigs at 7 to 11 kg body weight"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9721","authenticated-orcid":false,"given":"Yi-Chi","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-lim","family":"Lee","sequence":"additional","affiliation":[{"name":"CJ Cheiljedang , Seoul, 04560 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunil","family":"Hwang","sequence":"additional","affiliation":[{"name":"CJ Cheiljedang , Seoul, 04560 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4591-1943","authenticated-orcid":false,"given":"Sung Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Animal Science, North Carolina State University , Raleigh, NC 27695 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,11,28]]},"reference":[{"key":"2023112803221711800_CIT0001","volume-title":"Official methods of analysis of AOAC international","author":"AOAC Int.","year":"2007","edition":"18"},{"key":"2023112803221711800_CIT0002","doi-asserted-by":"crossref","first-page":"134529","DOI":"10.1016\/j.neulet.2019.134529","article-title":"Gastrin releasing peptide-induced satiety is associated with hypothalamic and brainstem changes in chicks","volume":"713","author":"Bohler","year":"2019","journal-title":"Neurosci. 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