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Sixty sows (Duroc\u2005\u00d7\u2005Yorkshire\u2005\u00d7\u2005Landrace; parity\u2005=\u20051.68\u2005\u00b1\u20050.03; N\u2005=\u200520) were randomly divided into three gestation (day 60 of pregnancy) treatments, Control pigs (CON) were fed a basal diet, and the other animals were fed a basal diet supplemented with 200 or 600 mg\/kg embelin per kg of feed. The body weight, backfat thickness and litter size of the sows, and birth weight and mortality of piglets were recorded. Sows\u2019 blood and piglets\u2019 umbilical cord blood were collected for the measurements of hematological parameters and anti-oxidative and immune indexes, and maternal\u2013fetal glucose metabolism parameters, respectively. The colostrum and milk and fecal samples of the sows were also collected for analysis of milk composition and apparent total tract nutrient digestibility. Dietary embelin had no effect on the BW and backfat thickness of the sows but significantly increased the birth weight of piglets (P\u2005&amp;lt;\u20050.05) and decreased the mortality (P\u2005&amp;lt;\u20050.05). Moreover, the white blood cell counts (day 90), neutrophil count and mean cell hemoglobin (day 110), total anti-oxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) content of the sows were increased significantly (P\u2005&amp;lt;\u20050.05) in the embelin groups than that in the CON group, whereas the malondialdehyde (MDA) content was decreased (P\u2005&amp;lt;\u20050.05). Embelin significantly increased immunoglobulin A (IgA) and immunoglobulin G (IgG) content in plasma of piglets as well as those in colostrum and milk of sows than the CON treatment (P\u2005&amp;lt;\u20050.05). In addition, dry matter, ash, and ether extract in the colostrum were similar between groups (P\u2005&amp;gt;\u20050.05), whereas the embelin significantly increased the crude protein in the milk. The apparent total tract nutrient digestibility was similar between treatments (P\u2005&amp;gt;\u20050.05). The embelin treatment significantly increased the glucose levels and lactate dehydrogenase B (LDHB) activity in sows plasma, and decreased the lactate levels in both sows and fetuses plasma (P\u2005&amp;lt;\u20050.05). Collectively, this study indicates that sows fed with embelin in mid-to-late gestation showed improved maternal health and anti-oxidative status, milk protein content, and maternal\u2013fetal glucose metabolism, showing promise in natural plant extract nutrition for sows.<\/jats:p>","DOI":"10.1093\/jas\/skad010","type":"journal-article","created":{"date-parts":[[2023,1,8]],"date-time":"2023-01-08T08:47:33Z","timestamp":1673167653000},"source":"Crossref","is-referenced-by-count":0,"title":["Dietary embelin supplementation during mid-to-late gestation improves performance and maternal\u2013fetal glucose metabolism of pigs"],"prefix":"10.1093","volume":"101","author":[{"given":"Tongxin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxi","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenrui","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5404-8091","authenticated-orcid":false,"given":"Feiruo","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,7]]},"reference":[{"key":"2023040704131225900_","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.biocel.2010.06.001","article-title":"The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes","volume":"42","author":"Al-Gubory","year":"2010","journal-title":"Int. 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