{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:38:03Z","timestamp":1792460283104,"version":"4.5.0"},"reference-count":69,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["#503732"],"award-info":[{"award-number":["#503732"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009011","name":"Ontario Centres of Excellence","doi-asserted-by":"publisher","award":["#26426"],"award-info":[{"award-number":["#26426"]}],"id":[{"id":"10.13039\/100009011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objectives were to evaluate the effects of complete replacement of supplementary inorganic salts of trace minerals (ITM; cobalt (Co), copper (Cu), manganese (Mn), zinc (Zn) sulfates and sodium (Na) selenite) by organic trace minerals (OTM; Co, Cu, Mn, Zn proteinates, and selenized yeast) in both pre- and postpartum diets on trace minerals (TM) concentrations in body fluids and liver, antioxidant and inflammation biomarkers in blood, and postpartum health of dairy cows. Pregnant cows were blocked by parity and body condition score and randomly assigned to ITM (n = 136) or OTM (n = 137) 45 d before expected calving. Both groups received the same pre- and postpartum diets except for the source of supplementary TM. The day of calving was considered study d 0 and blood was collected on d \u201345, \u201321, \u201314, \u201310, \u20137, \u20133, 0, 3, 7, 10, 14, 23, 65, and 105 for analyses of TM and biomarkers. Concentrations of TM were also investigated in the liver (d 105), milk (d 7, 23, 65, 105), urine (d \u201321, 21, 65, 105), ruminal fluid and feces (d \u201321, 21, 65). Incidence of clinical and subclinical health conditions were evaluated. Complete replacement of ITM by OTM resulted in greater concentration of selenium (Se) in serum (0.084 vs. 0.086 \u00b5g\/mL; P &amp;lt; 0.01), milk (0.24 vs. 0.31 \u00b5g\/g; P &amp;lt; 0.01), and ruminal fluid (0.54 vs. 0.58 \u00b5g\/g; P = 0.06), and reduced concentration of Se in urine (1.54 vs. 1.23 \u00b5g\/g; P&amp;lt;0.01). For concentration of Co in serum, an interaction between treatment and time was detected (P &amp;lt; 0.01). Cows supplemented with OTM had greater concentrations of Co on d \u20137 and 0 (0.30 vs. 0.33 ng\/mL; P &amp;lt; 0.01) but lower concentrations of Co on d 23, 65, and 105 (0.34 vs. 0.31 ng\/mL; P &amp;lt; 0.05), in addition to reduced concentration of Co in feces (1.08 vs. 0.99 \u00b5g\/g; P = 0.04) and, for multiparous only, in urine (0.019 vs. 0.014 \u00b5g\/g; P &amp;lt; 0.01). Cows supplemented with OTM had lower postpartum concentrations of glutamate dehydrogenase (20.8 vs. 17.8 U\/L; P &amp;lt; 0.05) and higher albumin on d \u201310 (36.0 vs. 36.7 g\/L; P = 0.04) and 23 (36.9 vs. 37.6 g\/L; P = 0.03) relative to calving. Primiparous cows fed OTM had lower concentration of ceruloplasmin in plasma (55 vs. 51 mg\/L; P \u2264 0.05). Cows supplemented with OTM had less incidence of lameness (14% vs. 7%; P = 0.05), elevated nonesterified fatty acids (NEFA) (61% vs. 44%; P &amp;lt; 0.01), and multiple metabolic problems (35% vs. 20%; P &amp;lt; 0.01). Despite the lack of differences in Cu, Mn, and Zn concentrations and antioxidant capacity, complete replacement of ITM by OTM altered concentrations of Se and Co, supported liver and hoof health, and reduced the risk of postpartum elevated NEFA.<\/jats:p>","DOI":"10.1093\/jas\/skad041","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T08:48:17Z","timestamp":1675414097000},"source":"Crossref","is-referenced-by-count":29,"title":["Effects of replacing inorganic salts of trace minerals with organic trace minerals in the pre- and postpartum diets on mineral status, antioxidant biomarkers, and health of dairy cows"],"prefix":"10.1093","volume":"101","author":[{"given":"Bruna","family":"Mion","sequence":"first","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn","family":"Van Winters","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose F W","family":"Spricigo","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Anan","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Duplessis","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, QC J1M 1Z3 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian W","family":"McBride","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J","family":"LeBlanc","sequence":"additional","affiliation":[{"name":"Department of Population Medicine, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo de Souza","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Animal Biosciences, University of Guelph , Guelph, ON N1G 2W1 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-5573-8-1","article-title":"WINPEPI updated: computer programs for epidemiologists, and their teaching potential.","volume":"8","author":"Abramson","year":"2011","journal-title":"Epidemiol Perspect Innov"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox8010020","article-title":"Redox biology in transition period of dairy cattle: role in the health of periparturient and neonatal animals","volume":"8","author":"Abuelo","year":"2019","journal-title":"Antioxidants"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.tvjl.2007.12.022","article-title":"Is there a role for organic trace element supplements in transition cow health?","volume":"176","author":"Andrieu","year":"2008","journal-title":"Vet. J"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3168\/jds.S0022-0302(98)75670-X","article-title":"Effect of selenium source supplements on the distribution of selenium among serum proteins in cattle","volume":"81","author":"Awadeh","year":"1998","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of \u201cantioxidant power\u201d: the FRAP assay","volume":"239","author":"Benzie","year":"1996","journal-title":"Anal. Biochem"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3168\/jds.S0022-0302(05)72878-2","article-title":"Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows","volume":"88","author":"Bernabucci","year":"2005","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"4281","DOI":"10.3168\/jds.2013-7832","article-title":"Effect of trace mineral supplementation on selected energy metabolites, oxidative stress, and immune parameters and its association with uterine diseases in dairy cattle","volume":"97","author":"Bicalho","year":"2014","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1146\/annurev-nutr-071714-034250","article-title":"Regulation of selenium metabolism and transport","volume":"35","author":"Burk","year":"2015","journal-title":"Annu. Rev. Nutr"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.livsci.2009.12.005","article-title":"Effects of either sodium selenite or Se yeast (Sc CNCM I-3060) supplementation on selenium status and milk characteristics in dairy cows","volume":"128","author":"Calamari","year":"2010","journal-title":"Livest. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1093\/jn\/122.11.2121","article-title":"Selenium deficiency alters the lipoxygenase pathway and mitogenic response in bovine lymphocytes","volume":"122","author":"Cao","year":"1992","journal-title":"J. Nutr"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2527\/2000.7882039x","article-title":"Chemical characteristics and relative bioavailability of supplemental organic zinc sources for poultry and ruminants","volume":"78","author":"Cao","year":"2000","journal-title":"J. Anim. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2527\/af.2012-0013","article-title":"Selenium in milk and human health.","volume":"4","author":"Cobo-Angel","year":"2014","journal-title":"Anim. Frontiers"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.livsci.2009.09.001","article-title":"Antioxidant enzymes and somatic cell count in dairy cows fed with organic source of zinc, copper and selenium","volume":"127","author":"Cortinhas","year":"2010","journal-title":"Livest. Sci"},{"key":"2023030816563164500_","first-page":"517","article-title":"Acute phase response in animals: a review","volume":"59","author":"Cray","year":"2009","journal-title":"Comp. Med"},{"key":"2023030816563164500_","volume-title":"Effect of dietary source of selenium on absorption, retention, performance, selenium status, and immune function in lactating dairy cattle","author":"Cruickshank","year":"2021"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3168\/jds.2010-3559","article-title":"Diagnosing intramammary infections: evaluation of definitions based on a single milk sample","volume":"94","author":"Dohoo","year":"2011","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3168\/jds.S0022-0302(96)76555-4","article-title":"Copper metabolism of Holstein and Jersey cows and heifers fed high in cupric sulfate or copper proteinate","volume":"79","author":"Du","year":"1996","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1159\/000480529","article-title":"Elevated apoptosis in the liver of dairy cows with ketosis","volume":"43","author":"Du","year":"2017","journal-title":"Cell. Physiol. Biochem"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.3168\/jds.2019-17657","article-title":"Cross-sectional study of the effect of diet composition on plasma folate and vitamin B12 concentrations in Holstein cows in the United States and Canada","volume":"103","author":"Duplessis","year":"2020","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/s12011-015-0560-8","article-title":"Rumen microorganisms decrease bioavailability of inorganic selenium supplements","volume":"171","author":"Galbraith","year":"2016","journal-title":"Biol. Trace Elem. Res"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/icb.1970.30","article-title":"The effect of cobalt intake on the cobamine and cobinamide composition of the rumen contents and blood plasma of sheep","volume":"48","author":"Gawthorne","year":"1970","journal-title":"Aust. J. Exp. Biol. Med. Sci"},{"key":"2023030816563164500_","first-page":"38","article-title":"An instrument for collection and transfer of ruminal fluid and for administration of water soluble drugs in adult cattle","volume":"27","author":"Geishauser","year":"1993","journal-title":"Bov. Pract"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.theriogenology.2005.04.022","article-title":"Prevalence of endometritis and its effects on reproductive performance of dairy cows","volume":"64","author":"Gilbert","year":"2005","journal-title":"Theriogenology"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"4524","DOI":"10.3168\/jds.2009-2049","article-title":"Apparent ruminal synthesis and intestinal disappearance of vitamin B12 and its analogs in dairy cows","volume":"92","author":"Girard","year":"2009","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.3168\/jds.2017-13112","article-title":"Invited review: Mineral absorption mechanisms, mineral interactions that affect acid-base and antioxidant status, and diet considerations to improve mineral status","volume":"101","author":"Goff","year":"2018","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s12011-018-1323-0","article-title":"Effect of organic selenium supplementation on selenium status, oxidative stress, and antioxidant status in selenium-adequate dairy cows during the periparturient period.","volume":"186","author":"Gong","year":"2018","journal-title":"Biol. Trace Elem. Res"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2527\/jas.2006-480","article-title":"Evaluation of classification modes potentially suitable to identify metabolic stress in healthy dairy cows during the peripartal period","volume":"85","author":"Hachenberg","year":"2007","journal-title":"J. Anim. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2527\/jas.2006-814","article-title":"Bioavailability of copper from copper glycinate in steers fed high dietary sulfur and molybdenum","volume":"86","author":"Hansen","year":"2008","journal-title":"J. Anim. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s00702-007-0687-7","article-title":"Ceruloplasmin and what it might do","volume":"144","author":"Healy","year":"2007","journal-title":"J. Neural Transm"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.3168\/jds.S0022-0302(92)78123-5","article-title":"Relative bioavailability of manganese from a manganese-methionine complex and inorganic sources for ruminants","volume":"75","author":"Henry","year":"1992","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.3168\/jds.S0022-0302(90)78920-5","article-title":"Relationship among vitamin E, selenium, and bovine neutrophils","volume":"73","author":"Hogan","year":"1990","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1042\/BST0361252","article-title":"Zinc-controlled gene expression by metal-regulatory transcription factor 1 (MTF1) in a model vertebrate, the zebrafish","volume":"36","author":"Hogstrand","year":"2008","journal-title":"Biochem. Soc. Trans"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13028-019-0470-4","article-title":"Validation of an automated assay for measurement of bovine plasma ceruloplasmin","volume":"61","author":"Hussein","year":"2019","journal-title":"Acta Vet. Scand"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/S0271-5317(97)00062-6","article-title":"Bioavailability of cobalt sources for ruminants. 3. In vitro ruminal production of vitamin B12 and total corrinoids in response to different cobalt sources and concentrations","volume":"6","author":"Kawashima","year":"1997","journal-title":"Nutr. Res"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"66","DOI":"10.15232\/S1080-7446(15)31274-2","article-title":"Inorganic versus complexed trace minerals supplements on performance of dairy cows","volume":"20","author":"Kincaid","year":"2004","journal-title":"Prof. Anim. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3168\/jds.S0022-0302(04)73203-8","article-title":"Peripartum serum vitamin E, retinol, and beta-carotene in dairy cattle and their association with disease","volume":"87","author":"LeBlanc","year":"2004","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2527\/jas.2015-0036","article-title":"Effects of organic or inorganic cobalt, copper, manganese, and zinc supplementation to late-gestating beef cows on productive and physiological responses of the offspring","volume":"94","author":"Marques","year":"2016","journal-title":"J. Anim. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.3168\/jds.2012-5812","article-title":"Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease","volume":"95","author":"Martinez","year":"2012","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3168\/jds.2019-17191","article-title":"Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows","volume":"103","author":"McArt","year":"2020","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"5056","DOI":"10.3168\/jds.2012-5443","article-title":"Epidemiology of subclinical ketosis in early lactation dairy cattle","volume":"95","author":"McArt","year":"2012","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.3168\/jds.2022-21908","article-title":"Effects of replacing inorganic salts of trace minerals with organic trace minerals in pre- and postpartum diets on feeding behavior, rumen fermentation, and performance of dairy cows","volume":"105","author":"Mion","year":"2022","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","volume-title":"Nutrient Requirements of Dairy Cattle. 8th rev. ed. National Academies Press","author":"NASEM. (National Academies of Sciences, Engineering, and Medicine).","year":"2021"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.3168\/jds.S0022-0302(06)72344-X","article-title":"The effect of trace mineral fortification level and source on performance of dairy cattle","volume":"89","author":"Nocek","year":"2006","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","volume-title":"Nutrient Requirements of Dairy Cows","author":"NRC","year":"2001","edition":"7"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"9944","DOI":"10.3168\/jds.2022-21909","article-title":"Neutrophil function and antibody production during the transition period: Effect of form of supplementary trace minerals and associations with postpartum clinical disease and blood metabolites","volume":"105","author":"Ogilvie","year":"2022","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3168\/jds.2015-10040","article-title":"Supplementing Zn, Mn, and Cu from amino acid complexes and Co from cobalt glucoheptonate during the perinatal period benefits postpartal cow performance and blood neutrophil function","volume":"99","author":"Osorio","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"9974","DOI":"10.3168\/jds.2015-10698","article-title":"Corium molecular biomarkers reveal a beneficial effect on hoof transcriptomics in peripartal dairy cows supplemented with zinc, manganese, and copper from amino acid complexes and cobalt from cobalt glucoheptonate","volume":"99","author":"Osorio","year":"2016","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.3168\/jds.2010-3074","article-title":"Association between the proportion of sampled transition cows with increased nonesterified fatty acids and \u03b2- hydroxybutyrate and disease incidence, pregnancy rate, and milk production at the herd level","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jtemb.2009.11.007","article-title":"Effect of copper- and zinc-methionine supplementation on bioavailability, mineral status and tissue concentrations of copper and zinc in ewes","volume":"24","author":"Pal","year":"2010","journal-title":"J. Trace Elem. Med. Biol"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"9151","DOI":"10.3168\/jds.2018-15879","article-title":"Association of dry matter intake and energy balance prepartum and postpartum with health disorders postpartum: Part II. Ketosis and clinical mastitis","volume":"102","author":"Perez-Baez","year":"2019","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.3168\/jds.2012-6335","article-title":"Prevalence of periparturient diseases and effects on fertility of seasonally calving grazing dairy cows supplemented with concentrated","volume":"96","author":"Ribeiro","year":"2013","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cvfa.2012.11.012","article-title":"Assessment and management of pain associated with lameness in cattle","volume":"29","author":"Shearer","year":"2013","journal-title":"Vet. Clin. North Am. Food Anim. Pract"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3168\/jds.2007-0779","article-title":"Effect of trace mineral source on lactation performance, claw integrity, and fertility of dairy cattle","volume":"91","author":"Siciliano-Jones","year":"2008","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1136\/vr.134.2.33","article-title":"Haptoglobin as an indicator of infection in sheep","volume":"134","author":"Skinner","year":"1994","journal-title":"Vet. Rec"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2008.10.305","article-title":"Impact of oxidative stress on health and immune function of dairy cows","volume":"128","author":"Sordillo","year":"2009","journal-title":"Vet. Immunol. Immunopathol"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1506S","DOI":"10.1093\/jn\/133.5.1506S","article-title":"Trace mineral bioavailability in ruminants","volume":"133","author":"Spears","year":"2003","journal-title":"J. Nutr"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tvjl.2007.12.015","article-title":"Role of antioxidants and trace elements in health and immunity of transition dairy cows","volume":"176","author":"Spears","year":"2008","journal-title":"Vet. J"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","DOI":"10.1079\/9781845934729.0000","volume-title":"Mineral nutrition of livestock","author":"Suttle","year":"2010","edition":"4"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"797","DOI":"10.3168\/jds.S0022-0302(04)73223-3","article-title":"Invited review: formation of keratins in the bovine claw: roles of hormones, minerals, and vitamins in functional claw integrity","volume":"87","author":"Tomlinson","year":"2004","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","first-page":"3","article-title":"Modulation of bovine mononuclear cell proliferation and cytokine production by dietary copper insufficiency","volume":"2","author":"Torre","year":"1996","journal-title":"J. Nutr. Immunol"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s12011-012-9585-4","article-title":"Effect of zinc source on performance, Zn status, immune response, and rumen fermentation of lactating cows","volume":"152","author":"Wang","year":"2013","journal-title":"Biol. Trace Elem. Res"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3168\/jds.S0022-0302(96)76343-9","article-title":"Bioavailability of copper proteinate and copper carbonate relative to copper sulfate in cattle","volume":"79","author":"Ward","year":"1996","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1017\/S0021859617000107","article-title":"Comparison of supplemental cobalt form on fibre digestion and cobalamin concentrations in cattle","volume":"155","author":"Waterman","year":"2017","journal-title":"J. Agric. Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.3168\/jds.2014-8598","article-title":"Effects of dry period length on milk production, body condition, metabolites, and hepatic glucose metabolism in dairy cows","volume":"98","author":"Weber","year":"2015","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","article-title":"Selenium sources for dairy cattle.","author":"Weiss","year":"2005"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1023\/A:1005828211506","article-title":"Clinical and pathological studies in cattle with hepatic disease","volume":"21","author":"West","year":"1997","journal-title":"Vet. Res. Comm"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3168\/jds.S0022-0302(04)73254-3","article-title":"Effect of zinc source and dietary levels on zinc metabolism in Holstein calves","volume":"87","author":"Wright","year":"2004","journal-title":"J. Dairy Sci"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1017\/S1751731118002525","article-title":"Effects of trace mineral amount and source on aspects of oxidative metabolism and responses in intramammary lipopolysaccharide challenge in midlactation dairy cows","volume":"13","author":"Yasui","year":"2019","journal-title":"Animal"},{"key":"2023030816563164500_","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.3168\/jds.2021-21225","article-title":"Symposium review: mechanistic insights into adipose tissue inflammation and oxidative stress in periparturient dairy cows","volume":"105","author":"Zachut","year":"2022","journal-title":"J. Dairy Sci"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skad041\/49084380\/skad041.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skad041\/49456829\/skad041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skad041\/49456829\/skad041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T21:43:17Z","timestamp":1679607797000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skad041\/7025338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":69,"URL":"https:\/\/doi.org\/10.1093\/jas\/skad041","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"skad041"}}