{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:38:26Z","timestamp":1788482306184,"version":"build-2803163510"},"reference-count":74,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T00:00:00Z","timestamp":1676592000000},"content-version":"vor","delay-in-days":47,"URL":"https:\/\/www.nationalarchives.gov.uk\/doc\/open-government-licence\/version\/3\/"}],"funder":[{"DOI":"10.13039\/100013183","name":"Swine Innovation Porc","doi-asserted-by":"publisher","award":["1795"],"award-info":[{"award-number":["1795"]}],"id":[{"id":"10.13039\/100013183","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centre de Recherche en Sciences Animales de Deschambault"},{"name":"Agri-March\u00e9, and Agriculture and Agri-Food Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study compared different dietary zinc oxide (ZnO) levels on zinc (Zn) and copper (Cu) metabolism in weaned pigs. One hundred twenty weaned piglets (7.96 \u00b1 1.17 kg; 21 d of age) were used in a completely randomized 3 \u00d7 4 factorial design composed with three levels of dietary ZnO at 100 (100Zn), 1,000 (1,000Zn), or 3,000 mg\/kg (3,000Zn) and four ages at slaughter at 21 (day 21), 23 (day 23), 35 (day 35), and 42 d (day 42). Dietary Cu levels were constant at 130 mg\/kg. Serum, jejunum, liver, and kidney levels of Zn and Cu as well as mRNA abundance of genes related to Zn and Cu metabolism were analyzed. Zinc levels were greatest in 3,000Zn piglets from day 35 in all tissues (P \u2264 0.01). In 3,000Zn piglets, mRNA expression of ZIP4 was reduced in jejunum whereas ZnT1 and MT3 were stimulated in jejunum and liver and MT1 in kidney (P \u2264 0.04) from day 35. Copper levels were greatest in jejunum (P = 0.06) and kidney (P \u2264 0.01; days 35 and 42 only) and lowest in liver and serum (P \u2264 0.01) of 3,000Zn piglets. In conclusion, the treatment containing 3,000 mg ZnO\/kg triggered Zn homeostatic mechanisms in weaned pigs and impaired Cu metabolism through high enterocyte and kidney Cu sequestration.<\/jats:p>","DOI":"10.1093\/jas\/skad055","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T18:09:48Z","timestamp":1676657388000},"source":"Crossref","is-referenced-by-count":15,"title":["Effects of dietary zinc oxide levels on the metabolism of zinc and copper in weaned pigs"],"prefix":"10.1093","volume":"101","author":[{"given":"Danyel Bueno","family":"Dalto","sequence":"first","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Audet","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Roy","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliny K\u00e9tilim","family":"Novais","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Desch\u00eane","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Goulet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de biologie, Universit\u00e9 de Sherbrooke , Sherbrooke, Qu\u00e9bec , Canada J1K 2R1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Jacques","family":"Matte","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Lapointe","sequence":"additional","affiliation":[{"name":"Sherbrooke Research and Development Centre, Agriculture and Agri-Food Canada , Sherbrooke, Quebec , Canada J1M 0C8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,2,17]]},"reference":[{"key":"2023031514521781100_","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res"},{"key":"2023031514521781100_","first-page":"77","article-title":"Recommended method for assaying serum zinc with flame atomic absorption","volume":"44","author":"Arnaud","year":"1986","journal-title":"Ann. 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Lett"},{"key":"2023031514521781100_","volume-title":"Code of practice for care and handling of pigs","author":"National Farm Animal Care Council.","year":"2014"},{"key":"2023031514521781100_","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1017\/S1751731119002829","article-title":"Tissue-specific profiling reveals modulation of cellular and mitochondrial oxidative stress in normal- and low-birthweight piglets throughout the peri-weaning period","volume":"14","author":"Novais","year":"2020","journal-title":"Animal"},{"key":"2023031514521781100_","doi-asserted-by":"crossref","first-page":"e0247188","DOI":"10.1371\/journal.pone.0247188","article-title":"Weaning differentially affects mitochondrial function, oxidative stress, inflammation and apoptosis in normal and low birth weight piglets","volume":"16","author":"Novais","year":"2021","journal-title":"PLoS One"},{"key":"2023031514521781100_","volume-title":"Nutrient requirements of swine","author":"NRC.","year":"2012","edition":"11"},{"key":"2023031514521781100_","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1248\/cpb.22.55","article-title":"Inhibitory effect of high dietary zinc on copper absorption in rats","volume":"22","author":"Ogiso","year":"1974","journal-title":"Chem. 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