{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:55:15Z","timestamp":1789520115164,"version":"build-2803163510"},"reference-count":54,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100005712","name":"University of Jordan","doi-asserted-by":"publisher","award":["2208"],"award-info":[{"award-number":["2208"]}],"id":[{"id":"10.13039\/501100005712","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Nebraska Food for Health"},{"name":"University of Nebraska Collaborative Initiative"},{"name":"U. S. Department of Agriculture Multistate\/Hatch","award":["NEB26-202\/W3112"],"award-info":[{"award-number":["NEB26-202\/W3112"]}]},{"name":"U. S. Department of Agriculture Multistate\/Hatch","award":["1011127"],"award-info":[{"award-number":["1011127"]}]},{"name":"U. S. Department of Agriculture Multistate\/Hatch","award":["NEB-26-252\/W4112"],"award-info":[{"award-number":["NEB-26-252\/W4112"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>An androgen excess ovarian micro-environment may limit follicle progression in sheep. Two populations of ewes with divergent follicular fluid androstenedione (A4) were identified in a flock in Jordan: High A4; (A4)\u2005\u2265\u200530 ng\/mL, (N\u2005=\u200512) or Control A4 (Control); A4\u2005\u2264\u200515 ng\/mL; (N\u2005=\u200512). We hypothesized High A4 ewes would have increased steroidogenic enzyme mRNA abundance, inflammation, and follicular arrest. Messenger RNA abundance for steroidogenic enzymes StAR, CYP17A1, CYP11A1, and HSD3B1 were increased in theca cells while CYP17A1, CYP19A1, and HSD3B1 were increased in granulosa cells in High A4 ewes compared to Control. Gonadotropin receptor mRNA expression for LHCGR was increased in theca and FSHR in granulosa in High A4 ewes. Messenger RNA expression of FOS when reduced, increases expression of CYP17A1 which was observed in High A4 granulosa cells compared to Control. Furthermore, High A4 ewes had greater numbers of primordial follicles (P\u2005&amp;lt;\u20050.001) and fewer developing follicles compared to Control before, and after 7 d of culture, indicating follicular arrest was not alleviated by cortex culture. Increased fibrosis in the ovarian cortex was detected in High A4 ewes relative to Control (P\u2005&amp;lt;\u20050.001) suggesting increased inflammation and altered extracellular matrix deposition. Thus, this High A4 ewes population has similar characteristics to High A4 cows and women with polycystic ovary syndrome suggesting that naturally occurring androgen excess occurs in multiple species and may be a causative factor in follicular arrest and subsequent female sub- or infertility.<\/jats:p>","DOI":"10.1093\/jas\/skad082","type":"journal-article","created":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T06:43:16Z","timestamp":1681627396000},"source":"Crossref","is-referenced-by-count":7,"title":["Sheep with ovarian androgen excess have fibrosis and follicular arrest with increased mRNA abundance for steroidogenic enzymes and gonadotropin receptors"],"prefix":"10.1093","volume":"101","author":[{"given":"Mohamed A","family":"Abedal-Majed","sequence":"first","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohannad","family":"Abuajamieh","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohmmad","family":"Al-Qaisi","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin M","family":"Sargent","sequence":"additional","affiliation":[{"name":"Department of Agriculture, Southeast Missouri State University, Cape Girardeau , MO 63701 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam H","family":"Titi","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mufeed A","family":"Alnimer","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anas","family":"Abdelqader","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad I","family":"Shamoun","sequence":"additional","affiliation":[{"name":"Department of Animal Production, School of Agriculture, The University of Jordan , Amman 11942 , Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-0426","authenticated-orcid":false,"given":"Andrea S","family":"Cupp","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Nebraska-Lincoln , Lincoln (UNL), Nebraska 68583 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"2023051514344239000_CIT0001","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/humrep\/dex036","article-title":"Clustering of PCOS-like traits in naturally hyperandrogenic female rhesus monkeys","volume":"32","author":"Abbott","year":"2017","journal-title":"Hum. 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