{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:25Z","timestamp":1787009065341,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T00:00:00Z","timestamp":1681344000000},"content-version":"vor","delay-in-days":102,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Mississippi Agricultural and Forestry Experiment Station"},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["1011100"],"award-info":[{"award-number":["1011100"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007917","name":"Agricultural Research Service","doi-asserted-by":"publisher","award":["6066-31000-015-00D"],"award-info":[{"award-number":["6066-31000-015-00D"]}],"id":[{"id":"10.13039\/100007917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Melatonin has been documented to alleviate compromised pregnancies and enhance livestock performance traits. The objective of this study was to determine the effect of prenatal and postnatal melatonin supplementation on overall calf performance and dam milking traits in relation to calves, molecular factors involved in growth and metabolism of calves, along with testicular physiology and fertility traits in subsequent bulls. On days 190, 220 and 250 of gestation, dams (N = 60) were administered either two subdermal ear melatonin implants (preMEL) or no implants (preCON). After parturition, birth weights were recorded and calves were blocked based on prenatal treatment and sex. Calves received either melatonin implants (posMEL) or none (posCON) on days 0, 30, and 60 of age. On day 60 of lactation, a subset of dams (N = 32) were selected based on age, weight, and calf sex for milk collection and analysis. At weaning, (day 210 postnatally) calf weight, morphometric data, liver samples, and loin samples were collected. At 12 mo of age, bull (N = 30) scrotal circumference, scrotal temperature, and testicular artery measurements were recorded. Milk yield and fat percent from dams tended to decrease in the preMEL group (P &amp;lt; 0.07) compared with preCON group. Prenatal melatonin administration did not affect (P = 0.95) calf birth weight and similarly calf weaning weight was unaffected (P &amp;lt; 0.10) by prenatal or postnatal melatonin supplementation. Blood analysis demonstrated that plasma concentrations of melatonin were not different (P = 0.12) in dams; however, an increase (P &amp;lt; 0.001) in plasma concentrations of melatonin was observed in posMEL vs. posCON calves. A tendency (P &amp;lt; 0.10) for decreased MYF5 and MYOD1 expression in loin muscle was observed in the posMEL calves. Prenatal and postnatal melatonin administration did not affect subsequent bull scrotal measurements or testicular hemodynamics (P \u2265 0.14). Administering supplemental melatonin via implants during the prenatal and postnatal phase did not alter performance characteristics in offspring. In this study, dams were implanted in winter months, whereas calves were implanted in the spring months. Seasonal differences involving photoperiod and ambient temperature might have attributed to a lack of differences in melatonin levels during the prenatal phase. In the postnatal period, the level of developmental plasticity appears to be too low for melatonin properties to be effective.<\/jats:p>","DOI":"10.1093\/jas\/skad111","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T11:49:17Z","timestamp":1681386557000},"source":"Crossref","is-referenced-by-count":7,"title":["Effects of prenatal and postnatal melatonin supplementation on overall performance, male reproductive performance, and testicular hemodynamics in beef cattle"],"prefix":"10.1093","volume":"101","author":[{"given":"Dana S","family":"Reid","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, Mississippi 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W","family":"Geary","sequence":"additional","affiliation":[{"name":"USDA-ARS, Livestock and Range Research Laboratory , Fort Keogh, Miles City, Montana 59301 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail L","family":"Zezeski","sequence":"additional","affiliation":[{"name":"USDA-ARS, Livestock and Range Research Laboratory , Fort Keogh, Miles City, Montana 59301 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-3517","authenticated-orcid":false,"given":"Richard C","family":"Waterman","sequence":"additional","affiliation":[{"name":"USDA-ARS, Livestock and Range Research Laboratory , Fort Keogh, Miles City, Montana 59301 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-0249","authenticated-orcid":false,"given":"Megan L","family":"Van Emon","sequence":"additional","affiliation":[{"name":"Department of Animal and Range Sciences, Montana State University , Bozeman, Montana 59717 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riley D","family":"Messman","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, Mississippi 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derris D","family":"Burnett","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, Mississippi 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1377-0664","authenticated-orcid":false,"given":"Caleb O","family":"Lemley","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences, Mississippi State University , Mississippi State, Mississippi 39762 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,4,13]]},"reference":[{"key":"2024041301133542300_CIT0001","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3109\/19396360903469307","article-title":"ENOS, NO, and the activation of ERK and AKT signaling at mid-gestation and near-term in an ovine model of intrauterine growth restriction","volume":"56","author":"Arroyo","year":"2010","journal-title":"Sys. 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