{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:14:22Z","timestamp":1782303262791,"version":"3.54.5"},"reference-count":78,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our objectives were to assess the effects of eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) supplementation to pregnant ewes during the first third of gestation on their offspring\u2019s liver, adipose, and muscle tissues fatty acid (FA) profile and liver mRNA expression after a finishing period receiving diets with different FA profiles. Twenty-four post-weaning lambs, blocked by sex and body weight, were used in a 2 \u00d7 2 factorial arrangement of treatments. The first factor was dam supplementation (DS) in the first third of gestation with 1.61% of Ca salts of palm fatty acid distillate (PFAD) or Ca salts enriched with EPA-DHA. Ewes were exposed to rams with marking paint harnesses during the breeding. Ewes started DS at the day of mating, considered day 1 of conception. Twenty-eight days after mating, ultrasonography was used to confirm pregnancy, and nonpregnant ewes were removed from the groups. After weaning, the offspring lambs were supplemented (LS, second main factor) with two different FA sources (1.48% of PFAD or 1.48% of EPA-DHA) during the growing and fattening phase. Lambs were fed the LS diet for 56 d and sent to slaughter, where the liver, muscle, and adipose tissue samples were collected for FA analysis. Liver samples were collected for relative mRNA expression for genes associated with FA transport and metabolism. The data were analyzed as a mixed model in SAS (9.4). In the liver, the amount of C20:5 and C22:6 (P &amp;lt; 0.01) increased in lambs with LS-EPA-DHA, while some C18:1 cis FA isomers were greater in the lambs from DS-PFAD. In muscle, amounts of C22:1, C20:5, and C22:5 increased (P &amp;lt; 0.05) in lambs born from DS-EPA-DHA. The adipose tissue amounts of C20:5, C22:5, and C22:6 were greater (P &amp;lt; 0.01) in lambs from LS-EPA-DHA. Interactions (DS \u00d7 LS; P &amp;lt; 0.05) were observed for DNMT3\u03b2, FABP-1, FABP-5, SCD, and SREBP-1; having greater mRNA expression in liver tissue of LS-EPA-DHA, DS-PFAD and LS-PFAD, DS-EPA-DHA lambs compared with the lambs in the other two treatments. Liver ELOVL2 mRNA relative expression (P &amp;lt; 0.03) was greater in the offspring of DS-PFAD. Relative mRNA expression (P &amp;lt; 0.05) of GLUT1, IGF-1, LPL, and PPAR\u03b3 increased in the liver from LS-EPA-DHA lambs. Dam supplementation during early gestation using with different FA sources changed the lipid FA profile in MT, LT, and SAT during the finishing period depending on the tissue and type of FA source administered during the growing phase.<\/jats:p>","DOI":"10.1093\/jas\/skad144","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T21:36:06Z","timestamp":1683754566000},"source":"Crossref","is-referenced-by-count":8,"title":["Ewe early gestation supplementation with eicosapentaenoic and docosahexaenoic acids affects the liver, muscle, and adipose tissue fatty acid profile and liver mRNA expression in the offspring"],"prefix":"10.1093","volume":"101","author":[{"given":"Jos\u00e9 A","family":"Roque-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC) , Wooster, OH 44691 , USA"},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria , San Luis Potos\u00ed 78175 , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario F","family":"Oviedo-Ojeda","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC) , Wooster, OH 44691 , USA"},{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria , San Luis Potos\u00ed 78175 , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Whalin","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC) , Wooster, OH 44691 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9ctor A","family":"Lee-Rangel","sequence":"additional","affiliation":[{"name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed, Facultad de Agronom\u00eda y Veterinaria , San Luis Potos\u00ed 78175 , M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1288-3037","authenticated-orcid":false,"given":"Alejandro E","family":"Relling","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, The Ohio State University, Ohio Agricultural Research and Development Center (OARDC) , Wooster, OH 44691 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"2023061315104386400_CIT0001","first-page":"103","article-title":"Dietary lipid during late-pregnancy and early-lactation to manipulate metabolic and inflammatory gene network expression in dairy cattle liver with a focus on PPARs.","volume":"7","author":"Akbar","year":"2013","journal-title":"Gene Regul"},{"issue":"6 Suppl","key":"2023061315104386400_CIT0002","doi-asserted-by":"crossref","first-page":"588S","DOI":"10.1080\/07315724.2004.10719428","article-title":"The developmental origins of adult disease","volume":"23","author":"Barker","year":"2004","journal-title":"J. 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