{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:24:33Z","timestamp":1791919473614,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study was conducted to investigate the effects of supplementing different ratios of phytogenic feed additives (PFA) to weaned pigs challenged with pathogenic Escherichia coli on growth performance, nutrient digestibility, intestinal barrier integrity, and immune response, and to determine the optimal mixing ratio for post-weaning diarrhea (PWD) prevention. A total of 48 4-wk-old weaned pigs with initial body weight of 8.01 \u00b1 0.39 kg were placed in individual metabolic cages, and then randomly assigned to eight treatment groups. The eight treatments were as follows: a basal diet without E. coli challenge (negative control, NC), a basal diet with E. coli challenge (positive control, PC), PC with supplementing 0.1% mixture of 20% bitter citrus extract (BCE), 10% microencapsulated blend of thymol and carvacrol (MEO), and 70% excipient (T1), PC with supplementing 0.1% mixture of 10% MEO, 20% premixture of grape seed and grape marc extract, green tea, and hops (PGE), and 60% excipient (T2), PC with supplementing 0.1% mixture of 10% BCE, 10% MEO, 10% PGE, and 70% excipient (T3), PC with supplementing 0.1% mixture of 20% BCE, 20% MEO, and 60% excipient (T4), PC with supplementing 0.1% mixture of 20% MEO, 20% PGE, and 60% excipient (T5), and PC with supplementing 0.1% mixture of 10% BCE, 20% MEO, 10% PGE, and 60% excipient (T6). The experiments progressed in 16 days, including 5 days before and 11 days after the first E. coli challenge (day 0). In the E. coli challenge treatments, all pigs were orally inoculated by dividing a total of 10 mL of E. coli F 18 for three consecutive days from day 0 postinoculation (PI). Compared with the PC group, the PFA2 and PFA6 groups significantly increased (P &amp;lt; 0.05) feed efficiency and decreased (P &amp;lt; 0.05) diarrhea during the entire period. At day 11 PI, the PFA6 group significantly improved (P &amp;lt; 0.05) gross energy digestibility compared to the PFA1 group. The PFA6 group significantly decreased (P &amp;lt; 0.05) tumor necrosis factor \u03b1 (TNF-\u03b1) and interleukin-6 in serum and increased (P &amp;lt; 0.05) the villus height to crypt depth ratio (VH:CD). The PFA2 significantly decreased (P &amp;lt; 0.05) the relative protein expression of calprotectin in the ileum. In conclusion, improvements in growth performance, diarrhea reduction, and immunity enhancement are demonstrated when 10% BCE, 20% MEO, 10% PGE, and 60% excipient are mixed.<\/jats:p>","DOI":"10.1093\/jas\/skad148","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T18:38:55Z","timestamp":1683830335000},"source":"Crossref","is-referenced-by-count":17,"title":["Effect of different ratios of phytogenic feed additives on growth performance, nutrient digestibility, intestinal barrier integrity, and immune response in weaned pigs challenged with a pathogenic <i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5238-2982","authenticated-orcid":false,"given":"Se Yeon","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Poultry Science, University of Georgia , Athens, GA 30602 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Woo","family":"An","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Cheol","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ah","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Ho","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Yeol","family":"Cho","sequence":"additional","affiliation":[{"name":"Research Center, Eugene-Bio , Suwon 16675 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Jun","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Center, Eugene-Bio , Suwon 16675 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Center, Eugene-Bio , Suwon 16675 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Chungbuk National University , Cheongju 28644 , South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2023052911142277000_CIT0001","doi-asserted-by":"crossref","first-page":"683","DOI":"10.5713\/ajas.2012.12683","article-title":"Effects of resveratrol and essential oils on growth performance, immunity, digestibility and fecal microbial shedding in challenged piglets.","volume":"26","author":"Ahmed","year":"2013","journal-title":"Asian Australas. 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