{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T11:54:34Z","timestamp":1753876474796,"version":"3.41.2"},"reference-count":51,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T00:00:00Z","timestamp":1686873600000},"content-version":"vor","delay-in-days":166,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["#97875"],"award-info":[{"award-number":["#97875"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Texas A&M University, College of Veterinary Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A sodium pentobarbital-induced sleep time study was conducted on 15 adult intact male Boer \u00d7 Spanish goats selected for high (J+, n = 7) or low (J\u2212, n = 8) juniper consumption (estimated breeding values of 13.1 \u00b1 1.0 and \u221214.3 \u00b1 0.8, respectively; mean \u00b1 standard deviation). Pentobarbital sleep time is an in vivo assay of Phase I hepatic metabolism that can be induced by exposure to barbiturates and monoterpenes. Monoterpenes and pentobarbital are initially oxidized by this pathway; thus, we hypothesized that J+ goats would have shorter sleep times than J\u2212 goats. Time to the righting reflex after pentobarbital-induced sleep was measured in all goats following a minimum period of 21 d on three different diets: 1) grazing juniper-infested rangeland (JIR), 2) forage diet with no monoterpenes (M0), and 3) forage diet with 8 g\/kg added monoterpenes from camphor, sabinene, and \u03b1-pinene in a w\/w ratio of 5:4:1 (M+). Fecal samples from the JIR diet were analyzed with near-infrared spectroscopy for the percentage of juniper in the diet. Fecal samples from the JIR and M+ diets were analyzed for camphor and sabinene concentrations. The percentage of juniper in the diet of J+ goats grazing rangelands was greater (P = 0.001) than J\u2212 goats (31.1% and 18.6%, respectively). Sleep time did not differ between selection lines (P = 0.36). However, the sleep time of the goats fed M+ diet was 26 min shorter (P &amp;lt; 0.001) than JIR or M0 diets, which were equal. The concentration of camphor and sabinene in the feces was higher (P &amp;lt; 0.001) for goats on the M+ diet than on the JIR diet. There were no differences between selection lines in the serum enzymes indicative of liver disease (aspartate aminotransferase, bilirubin, gamma-glutamyl transferase, and glutamate dehydrogenase; P &amp;gt; 0.12), and all treatment means were within the reference interval. Selecting goats for juniper consumption did not affect the Phase I detoxification system, and several alternative hypotheses for differences in juniper consumption between J+ and J\u2212 goats are discussed.<\/jats:p>","DOI":"10.1093\/jas\/skad180","type":"journal-article","created":{"date-parts":[[2023,6,17]],"date-time":"2023-06-17T00:14:25Z","timestamp":1686960865000},"source":"Crossref","is-referenced-by-count":2,"title":["Selecting goats for juniper consumption did not improve their liver Phase I detoxification"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7844-3448","authenticated-orcid":false,"given":"John W","family":"Walker","sequence":"first","affiliation":[{"name":"Texas A&M AgriLife Research and Extension Center , San Angelo, TX 76901 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-6394","authenticated-orcid":false,"given":"Brian M","family":"Shoemake","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine & Biomedical Sciences, Texas A&M University , College Station, TX 77843 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9061-9071","authenticated-orcid":false,"given":"Danilo G","family":"Quadros","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research and Extension Center , San Angelo, TX 76901 , USA"},{"name":"University of Arkansas System Division of Agriculture, Animal Science Department , 2301 South University Avenue, Little Rock, AR 72204 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3553-7628","authenticated-orcid":false,"given":"Jacob W","family":"Thorne","sequence":"additional","affiliation":[{"name":"Texas A&M AgriLife Research and Extension Center , San Angelo, TX 76901 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8792-8802","authenticated-orcid":false,"given":"Noah C","family":"Cahill","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine & Biomedical Sciences, Texas A&M University , College Station, TX 77843 , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,6,16]]},"reference":[{"key":"2024061600012776200_CIT0001","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bse.2012.09.020","article-title":"Differences in chemical composition between browsed and non-browsed Juniperus ashei Buch. trees","volume":"46","author":"Adams","year":"2013","journal-title":"Biochem. 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