{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T03:39:55Z","timestamp":1770608395606,"version":"3.49.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T00:00:00Z","timestamp":1691366400000},"content-version":"vor","delay-in-days":218,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFD1601600"],"award-info":[{"award-number":["2022YFD1601600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"China Agriculture Research System","award":["CARS-37"],"award-info":[{"award-number":["CARS-37"]}]},{"DOI":"10.13039\/501100005045","name":"MOF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009233","name":"MARA","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009233","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Caustic paste disbudding (CPD) is widely utilized for calves, which has been known to result in adverse effects on the calves and ethical concerns related to animal welfare, despite the use of local anesthetics. The administration of meloxicam has been demonstrated to provide benefits in alleviating pain and inflammation in juvenile calves under 9 d old and subjected to CPD. Nonetheless, there is a scarcity of literature documenting the beneficial impact of meloxicam in alleviating pain in calves aged over 9 d that have undergone CPD. Therefore, the objective of this clinical trial was to evaluate the efficacy of administering meloxicam and lidocaine for cornual nerve block together in mitigating the deleterious effects of CPD, as opposed to using lidocaine alone in calves older than 9 d. Thirty Holstein calves, aged between 10 and 21 d, were enrolled and randomly assigned to 1 of 2 treatments: lidocaine alone (Placebo), lidocaine and normal saline treatment before CPD, and lidocaine plus meloxicam, lidocaine and 0.5 mg\/kg of meloxicam treatment prior to CPD. The researchers were blind to the treatment of calves to control the subjective error. The occurrences of actions associated with pain, which included head shaking, head rubbing, ear flicking, tail flicking, kicking, and head passing through the fence, were recorded. Physiological performance, including the respiration rate, heart rate, rectal temperature, mechanical nociceptive threshold (MNT), food intake, and daily activity level, was monitored. Hematological conditions were ascertained through the use of routine blood tests and enzyme-linked immunosorbent assay. The generalized linear mixed model was employed to analyze the data. The research findings revealed that applying the CPD procedure significantly elevated the frequencies of tail flicking, head shaking, and kicking, resulted in increases in respiratory rate, heart rate, daily active steps, and food intake and a decrease in MNT, and led to alterations in hematological markers, including platelet counts, mean platelet volume, prostaglandin E2, constitutive nitric oxide synthase, and hydroxyl radical. Considerable benefits, such as lower heart rates, higher food intake, and MNTs, as well as lower levels of white blood cell counts, lymphocyte counts, hemoglobin, mean platelet volume, prostaglandin E2, tumor necrosis factor-\u03b1, constitutive nitric oxide synthase, malondialdehyde, and hydroxyl radical, were observed in the calves that received meloxicam treatment in response to CPD. The findings of the study indicate that the co-administration of lidocaine and meloxicam provides obvious benefits in mitigating pain, inflammation, and oxidative stress in calves aged over 9 d and undergoing CPD. This endorses the use of meloxicam during the disbudding and dehorning procedures of calves.<\/jats:p>","DOI":"10.1093\/jas\/skad266","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T12:01:43Z","timestamp":1691409703000},"source":"Crossref","is-referenced-by-count":4,"title":["A Clinical Trial on the Welfare Effects of Administering Meloxicam to 10 to 21 Day Dairy Calves Following Caustic Paste Disbudding"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-8497","authenticated-orcid":false,"given":"Jiancheng","family":"Qi","sequence":"first","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Fang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"},{"name":"Animal Disease Control and Prevention Center of Zhongjiang County , Deyang, Sichuan 618100 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maqsood Ahmed","family":"Kumbhar","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengmin","family":"Cui","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongrui","family":"Guo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuhong","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Geng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanchun","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junliang","family":"Deng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuming","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Mujtaba","family":"Shah","sequence":"additional","affiliation":[{"name":"Institute of Animal Nutrition, Sichuan Agricultural University , Chengdu 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhicai","family":"Zuo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan 611130 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"2023082912292779600_CIT0001","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1038\/s41598-020-60260-7","article-title":"Conditioned place preference reveals ongoing pain in calves 3 weeks after disbudding","volume":"10","author":"Adcock","year":"2020","journal-title":"Sci. Rep"},{"key":"2023082912292779600_CIT0002","doi-asserted-by":"crossref","first-page":"5194","DOI":"10.3168\/jds.2012-6251","article-title":"The effect of timing of oral meloxicam administration on physiological responses in calves after cautery dehorning with local anesthesia","volume":"96","author":"Allen","year":"2013","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0003","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.jss.2011.01.038","article-title":"Oxidative stress in laparoscopic versus open abdominal surgery: a systematic review","volume":"169","author":"Arsalani-Zadeh","year":"2011","journal-title":"J. Surg. Res"},{"key":"2023082912292779600_CIT0004","author":"Association Canadian Veterinary Medical","year":"2016"},{"key":"2023082912292779600_CIT0005","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/aob\/mcf118","article-title":"Antioxidants, oxidative damage and oxygen deprivation stress: a review","volume":"91","author":"Blokhina","year":"2003","journal-title":"Ann. Bot"},{"key":"2023082912292779600_CIT0006","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0168-1591(98)00218-4","article-title":"Behavioural and physiological responses of calves to dehorning by heat cauterization with or without local anaesthesia","volume":"62","author":"Bruno","year":"1999","journal-title":"Appl. Anim. Behav. Sci"},{"key":"2023082912292779600_CIT0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1746-6148-8-153","article-title":"Pharmacokinetics and effect of intravenous meloxicam in weaned Holstein calves following scoop dehorning without local anesthesia","volume":"8","author":"Coetzee","year":"2012","journal-title":"BMC Vet. Res"},{"key":"2023082912292779600_CIT0008","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.livsci.2015.05.011","article-title":"Dehorning of cattle in the EU member states: a quantitative survey of the current practices","author":"Cozzi","year":"2015","journal-title":"Livest. Sci"},{"key":"2023082912292779600_CIT0009","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.theriogenology.2021.08.008","article-title":"Genetic evaluation for reproductive and productive traits in Brahman cattle","volume":"173","author":"de Oliveira","year":"2021","journal-title":"Theriogenology"},{"key":"2023082912292779600_CIT0010","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.3168\/jds.2007-0080","article-title":"Effects of a concentrated lidocaine solution on the acute phase stress response to dehorning in dairy calves","volume":"90","author":"Doherty","year":"2007","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0011","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.3168\/jds.2020-18299","article-title":"Conditioned place aversion of caustic paste and hot-iron disbudding in dairy calves","volume":"103","author":"Ede","year":"2020","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0012","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1177\/1091581812442939","article-title":"Meloxicam modulates oxidative stress status, inhibits prostaglandin E2, and abrogates apoptosis in carbon tetrachloride-induced rat hepatic injury","volume":"31","author":"Edfawy","year":"2012","journal-title":"Int. J. Toxicol"},{"key":"2023082912292779600_CIT0013","first-page":"158","article-title":"Effect of temperature, relative humidity and medium on the aerosol stability of infectious bovine rhinotracheitis virus","volume":"43","author":"Elazhary","year":"1979","journal-title":"Can. J. Comp. Med"},{"key":"2023082912292779600_CIT0014","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1007\/s11064-020-03054-7","article-title":"Effects of diclofenac versus meloxicam in pentylenetetrazol-kindled mice","volume":"45","author":"Elgarhi","year":"2020","journal-title":"Neurochem. Res"},{"key":"2023082912292779600_CIT0015","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.3168\/jds.S0022-0302(00)75084-3","article-title":"Reducing pain after dehorning in dairy calves","volume":"83","author":"Faulkner","year":"2000","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0016","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.rvsc.2013.01.018","article-title":"A study to compare circulating flunixin, meloxicam and gabapentin concentrations with prostaglandin E2 levels in calves undergoing dehorning","volume":"95","author":"Fraccaro","year":"2013","journal-title":"Res. Vet. Sci"},{"key":"2023082912292779600_CIT0017","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0049-0172(97)80049-2","article-title":"Meloxicam: selective COX-2 inhibition in clinical practice","volume":"26","author":"Furst","year":"1997","journal-title":"Semin. Arthritis Rheum"},{"key":"2023082912292779600_CIT0018","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3390\/ani12050533","article-title":"Behavioral and physiological response to routine thermal disbudding in dairy calves treated with transdermal flunixin meglumine","volume":"12","author":"Gaab","year":"2022","journal-title":"Animals"},{"key":"2023082912292779600_CIT0019","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1111\/jvp.12042","article-title":"The pharmacokinetics and effects of meloxicam, gabapentin, and flunixin in postweaning dairy calves following dehorning with local anesthesia","volume":"36","author":"Glynn","year":"2013","journal-title":"J. Vet. Pharmacol. Ther"},{"key":"2023082912292779600_CIT0020","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s11916-016-0591-7","article-title":"NSAIDs in the treatment of postoperative pain","volume":"20","author":"Gupta","year":"2016","journal-title":"Curr. Pain Headache Rep"},{"key":"2023082912292779600_CIT0021","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.3168\/jds.2009-2813","article-title":"The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic","volume":"93","author":"Heinrich","year":"2010","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0022","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3168\/jds.2008-1424","article-title":"The impact of meloxicam on postsurgical stress associated with cautery dehorning","volume":"92","author":"Heinrich","year":"2009","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0023","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fvets.2018.00117","article-title":"Welfare effects of the use of a combination of local anesthesia and NSAID for disbudding analgesia in dairy calves-reviewed across different welfare concerns","volume":"5","author":"Herskin","year":"2018","journal-title":"Front. Vet. Sci"},{"key":"2023082912292779600_CIT0024","author":"Janzen","year":"2022"},{"key":"2023082912292779600_CIT0025","doi-asserted-by":"crossref","first-page":"txz151","DOI":"10.1093\/tas\/txz151","article-title":"Efficacy of oral meloxicam as primary pain mitigation following caustic paste disbudding of three day old Holstein calves","volume":"5","author":"Karlen","year":"2021","journal-title":"Transl. Anim. Sci"},{"key":"2023082912292779600_CIT0026","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/bs.podrm.2019.10.006","article-title":"Meloxicam","volume-title":"Profiles Drug. Subst. Excip. Relat. Methodol.","author":"Khalil","year":"2020"},{"key":"2023082912292779600_CIT0027","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.niox.2011.07.002","article-title":"The role of nitric oxide in prostaglandin biology; update","volume":"25","author":"Kim","year":"2011","journal-title":"Nitric Oxide"},{"key":"2023082912292779600_CIT0028","first-page":"1993","article-title":"Effects of transdermal flunixin meglumine on pain biomarkers at dehorning in calves","volume":"95","author":"Kleinhenz","year":"2017","journal-title":"J. Anim. Sci"},{"key":"2023082912292779600_CIT0029","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.3168\/jds.S0022-0302(85)81203-0","article-title":"Effects of stress from electrical dehorning on feed intake, growth, and blood constituents of Holstein heifer calves","volume":"68","author":"Laden","year":"1985","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0030","doi-asserted-by":"crossref","first-page":"104819","DOI":"10.1016\/j.applanim.2019.05.008","article-title":"Horned and dehorned dairy cows differ in the pattern of agonistic interactions investigated under different space allowances","volume":"218","author":"Lutz","year":"2019","journal-title":"Appl. Anim. Behav. Sci"},{"key":"2023082912292779600_CIT0031","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0034-5288(98)90010-8","article-title":"Effects of regional analgesia and\/or a non-steroidal anti-inflammatory analgesic on the acute cortisol response to dehorning in calves","volume":"64","author":"McMeekan","year":"1998","journal-title":"Res. Vet. Sci"},{"key":"2023082912292779600_CIT0032","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/00480169.1999.36120","article-title":"Effects of a local anaesthetic and a non-steroidal anti-inflammatory analgesic on the behavioural responses of calves to dehorning","volume":"47","author":"McMeekan","year":"1999","journal-title":"N. Z. Vet. J"},{"key":"2023082912292779600_CIT0033","doi-asserted-by":"crossref","first-page":"5765","DOI":"10.3168\/jds.2018-16021","article-title":"Invited review: a systematic review of the effects of prolonged cow-calf contact on behavior, welfare, and productivity","volume":"102","author":"Meagher","year":"2019","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/AR06044","article-title":"Genetic options to replace dehorning in beef cattle\u2014a review","volume":"58","author":"Prayaga","year":"2007","journal-title":"Aust. J. Agric. Res"},{"key":"2023082912292779600_CIT0035","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.3168\/jds.2019-18118","article-title":"Randomized control trial assessing the efficacy of pain control strategies for caustic paste disbudding in dairy calves younger than 9 days of age","volume":"103","author":"Reedman","year":"2020","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0036","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3168\/jdsc.2021-0121","article-title":"Risk factors for morbidity in 1- to 9-day-old dairy calves following caustic paste disbudding","volume":"2","author":"Reedman","year":"2021","journal-title":"JDS Commun"},{"key":"2023082912292779600_CIT0037","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.3168\/jds.2021-21349","article-title":"Graduate student literature review: role of pain mitigation on the welfare of dairy calves undergoing disbudding","volume":"105","author":"Reedman","year":"2022","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0038","doi-asserted-by":"crossref","first-page":"11995","DOI":"10.3168\/jds.2021-20411","article-title":"Disbudding and dehorning practices for preweaned dairy calves by farmers in Wisconsin, USA","volume":"104","author":"Saraceni","year":"2021","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0039","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.livsci.2015.05.017","article-title":"The history of breeding for polled cattle","volume":"179","author":"Schafberg","year":"2015","journal-title":"Livest. Sci"},{"key":"2023082912292779600_CIT0040","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.2527\/jas.2016-0308","article-title":"Assessing cow-calf welfare. Part 1: benchmarking beef cow health and behavior, handling; and management, facilities, and producer perspectives","volume":"94","author":"Simon","year":"2016","journal-title":"J. Anim. Sci"},{"key":"2023082912292779600_CIT0041","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.tvjl.2004.02.005","article-title":"Dehorning and disbudding distress and its alleviation in calves","volume":"169","author":"Stafford","year":"2005","journal-title":"Vet. J"},{"key":"2023082912292779600_CIT0042","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.applanim.2011.10.018","article-title":"Addressing the pain associated with disbudding and dehorning in cattle","volume":"135","author":"Stafford","year":"2011","journal-title":"Appl. Anim. Behav. Sci"},{"key":"2023082912292779600_CIT0043","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.physbeh.2007.11.044","article-title":"Eye temperature and heart rate variability of calves disbudded with or without local anaesthetic","volume":"93","author":"Stewart","year":"2008","journal-title":"Physiol. Behav"},{"key":"2023082912292779600_CIT0044","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.3168\/jds.2008-1578","article-title":"Effects of local anesthetic and a nonsteroidal antiinflammatory drug on pain responses of dairy calves to hot-iron dehorning","volume":"92","author":"Stewart","year":"2009","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0045","first-page":"281","article-title":"Comparing the effect of three different disbudding methods on behaviour and plasma cortisol of calves","volume":"102","author":"Stilwell","year":"2007","journal-title":"Rev. Port. Cienc. Vet"},{"key":"2023082912292779600_CIT0046","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2527\/jas.2015-9510","article-title":"Impact of carprofen administration on stress and nociception responses of calves to cautery dehorning","volume":"94","author":"Stock","year":"2016","journal-title":"J. Anim. Sci"},{"key":"2023082912292779600_CIT0047","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.3168\/jds.2014-8877","article-title":"The effects of firocoxib on cautery disbudding pain and stress responses in preweaned dairy calves","volume":"98","author":"Stock","year":"2015","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0048","doi-asserted-by":"crossref","first-page":"935","DOI":"10.2527\/jas.2012-5190","article-title":"Effect of castration and dehorning singularly or combined on the behavior and physiology of Holstein calves","volume":"91","author":"Sutherland","year":"2013","journal-title":"J. Anim. Sci"},{"key":"2023082912292779600_CIT0049","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1751-0813.1998.tb14544.x","article-title":"Acute cortisol responses of calves to four methods of dehorning by amputation","volume":"76","author":"Sylvester","year":"1998","journal-title":"Aust. Vet. J"},{"key":"2023082912292779600_CIT0050","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1751-0813.2004.tb12162.x","article-title":"Behavioural responses of calves to amputation dehorning with and without local anaesthesia","volume":"82","author":"Sylvester","year":"2004","journal-title":"Aust. Vet. J"},{"key":"2023082912292779600_CIT0051","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.2527\/jas.2009-2340","article-title":"Nonsteroidal anti-inflammatory drug therapy for neonatal calf diarrhea complex: effects on calf performance","volume":"88","author":"Todd","year":"2010","journal-title":"J. Anim. Sci"},{"key":"2023082912292779600_CIT0052","doi-asserted-by":"crossref","first-page":"e0198808","DOI":"10.1371\/journal.pone.0198808","article-title":"Evaluating treatments with topical anaesthetic and buccal meloxicam for pain and inflammation caused by amputation dehorning of calves","volume":"13","author":"Van der Saag","year":"2018","journal-title":"PLoS One"},{"key":"2023082912292779600_CIT0053","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3390\/ani8030035","article-title":"Effects of topical anaesthetic and buccal meloxicam treatments on concurrent castration and dehorning of beef calves","volume":"8","author":"Van der Saag","year":"2018","journal-title":"Animals"},{"key":"2023082912292779600_CIT0054","doi-asserted-by":"crossref","first-page":"643206","DOI":"10.3389\/fimmu.2021.643206","article-title":"Bovine immunology: implications for dairy cattle","volume":"12","author":"Vlasova","year":"2021","journal-title":"Front. Immunol"},{"key":"2023082912292779600_CIT0055","doi-asserted-by":"crossref","first-page":"6429","DOI":"10.3168\/jds.2017-12724","article-title":"Clinical trial of local anesthetic protocols for acute pain associated with caustic paste disbudding in dairy calves","volume":"100","author":"Winder","year":"2017","journal-title":"J. Dairy Sci"},{"key":"2023082912292779600_CIT0056","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.3168\/jds.2017-14092","article-title":"Effects of local anesthetic or systemic analgesia on pain associated with cautery disbudding in calves: a systematic review and meta-analysis","volume":"101","author":"Winder","year":"2018","journal-title":"J. Dairy Sci"}],"container-title":["Journal of Animal Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jas\/advance-article-pdf\/doi\/10.1093\/jas\/skad266\/51049870\/skad266.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skad266\/51279435\/skad266.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jas\/article-pdf\/doi\/10.1093\/jas\/skad266\/51279435\/skad266.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:38:15Z","timestamp":1693312695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jas\/article\/doi\/10.1093\/jas\/skad266\/7238421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":56,"URL":"https:\/\/doi.org\/10.1093\/jas\/skad266","relation":{},"ISSN":["0021-8812","1525-3163"],"issn-type":[{"value":"0021-8812","type":"print"},{"value":"1525-3163","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2023,1,1]]},"article-number":"skad266"}}