{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:22Z","timestamp":1753877122009,"version":"3.41.2"},"reference-count":87,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Stressors such as lack of access to feed, hot temperatures, transportation, and pen changes can cause impairment of ruminal and intestinal barrier function, also known as \u201cleaky gut\u201d. Despite the known benefits of some nutritional approaches during periods of stress, little is understood regarding the underlying mechanisms, especially in dairy cows. We evaluated the effect of feeding a Saccharomyces cerevisiae fermentation product (SCFP; NutriTek, Diamond V, Cedar Rapids, IA) on the ileal transcriptome in response to feed restriction (FR), an established model to induce intestinal barrier dysfunction. Multiparous cows [97.1\u2005\u00b1\u20057.6 days in milk (DIM); n\u2005=\u20055\/group] fed a control diet or control plus 19 g\/d SCFP for 9 wk were subjected to an FR challenge for 5 d during which they were fed 40% of their ad libitum intake from the 7 d before FR. All cows were slaughtered at the end of FR, and ileal scrapping RNA was used for RNAseq (NovaSeq 6000, 100 bp read length). Statistical analysis was performed in R and bioinformatics using the KEGG (Kyoto Encyclopedia of Genes and Genomes) and GO databases. One thousand six hundred and ninety-six differentially expressed genes (DEG; FDR-adjusted P\u2005\u2264\u20050.10) were detected in SCFP vs. control, with 451 upregulated and 1,245 downregulated. \u201cMucin type O-glycan biosynthesis\u201d was the top downregulated KEGG pathway due to downregulation of genes catalyzing glycosylation of mucins (GCNT3, GALNT5, B3GNT3, GALNT18, and GALNT14). An overall downregulation of cell and tissue structure genes (e.g., extracellular matrix proteins) associated with collagen (COL6A1, COL1A1, COL4A1, COL1A2, and COL6A2), laminin (LAMB2), and integrins (ITGA8, ITGA2, and ITGA5) also were detected with SCFP. A subset of DEG enriched in the GO term \u201cextracellular exosome\u201d and \u201cextracellular space\u201d. Chemokines within \u201cCytokine-cytokine receptor interaction pathways\u201d such as CCL16, CCL21, CCL14, CXCL12, and CXCL14 were downregulated by SCFP. The \u201cGlutathione metabolism\u201d pathway was upregulated by SCFP, including GSTA1 and RRM2B among the top upregulated genes, and GSTM1 and GPX8 as top downregulated genes. There were 9 homeobox transcription factors among the top 50 predicted transcription factors using the RNAseq DEG dataset, underscoring the importance of cell differentiation as a potential target of dietary SCFP. Taken together, SCFP downregulated immune-, ECM-, and mucin synthesis-related genes during FR. Homeobox transcription factors appear important for the transcriptional response of SCFP.<\/jats:p>","DOI":"10.1093\/jas\/skad277","type":"journal-article","created":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:12:18Z","timestamp":1692922338000},"source":"Crossref","is-referenced-by-count":1,"title":["Alterations in ileal transcriptomics during an intestinal barrier challenge in lactating Holstein cows fed a <i>Saccharomyces cerevisiae<\/i> fermentation product identify potential regulatory processes"],"prefix":"10.1093","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9522-4856","authenticated-orcid":false,"given":"Qianming","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Animal Sciences, University of Illinois , Urbana 61801, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3590-2963","authenticated-orcid":false,"given":"Valentino","family":"Palombo","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi del Molise , 86100, Campobasso , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle N","family":"Sherlock","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Illinois , Urbana 61801, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Vailati-Riboni","sequence":"additional","affiliation":[{"name":"Diamond V , Cedar Rapids 52404, IA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariasilvia","family":"D\u2019Andrea","sequence":"additional","affiliation":[{"name":"Universit\u00e0 degli Studi del Molise , 86100, Campobasso , Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilkyu","family":"Yoon","sequence":"additional","affiliation":[{"name":"Diamond V , Cedar Rapids 52404, IA , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1586-4365","authenticated-orcid":false,"given":"Juan J","family":"Loor","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences, University of Illinois , Urbana 61801, IL , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,24]]},"reference":[{"key":"2023101415021546400_CIT0001","doi-asserted-by":"crossref","first-page":"9634","DOI":"10.3168\/jds.2020-18721","article-title":"Effects of a Saccharomyces cerevisiae fermentation product on heat-stressed dairy cows","volume":"103","author":"Al-Qaisi","year":"2020","journal-title":"J. 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