{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:39:52Z","timestamp":1790199592480,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project","award":["TSBICIP-CXRC-038"],"award-info":[{"award-number":["TSBICIP-CXRC-038"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1300700"],"award-info":[{"award-number":["2021YFD1300700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study aimed to investigate the effects of dietary gamma-aminobutyric acid (GABA) supplementation on reproductive performance, glucose intolerance, and placental development of gilts during mid-late gestation. Based on the principle of backfat thickness consistency, 124 gilts at 65 d of gestation were assigned to three dietary groups: CON (basic diet, n\u2005=\u200541), LGABA (basic diet supplemented with 0.03% GABA, n\u2005=\u200542), and HGABA (basic diet supplemented with 0.06% GABA, n\u2005=\u200541). The litter performance, glucose tolerance, placental angiogenesis, and nutrients transporters were assessed. The LGABA group improved piglet vitality and placental efficiency and decreased area under the curve of glucose tolerance test compared to the CON group (P\u2005&amp;lt;\u20050.05). Meanwhile, the LGABA group enhanced placental vessel density, platelet endothelial cell adhesion molecule-1 levels and gene expression of fibroblast growth factor 18 (P\u2005&amp;lt;\u20050.05). Furthermore, LGABA showed an uptrend in glucose transporter type 1 mRNA level (P\u2005=\u20050.09). Taken together, this study revealed that the dietary supplementation of 0.03% GABA can improve piglet vitality, glucose intolerance, and placental development of gilts.<\/jats:p>","DOI":"10.1093\/jas\/skad405","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T15:46:59Z","timestamp":1703260019000},"source":"Crossref","is-referenced-by-count":4,"title":["Effects of dietary supplementation of different levels of gamma-aminobutyric acid on reproductive performance, glucose intolerance, and placental development of gilts"],"prefix":"10.1093","volume":"102","author":[{"given":"Shuo","family":"Ma","sequence":"first","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology , Tianjin 300308 , China"},{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxuan","family":"Ye","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangbo","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaidi","family":"Ma","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University , Guangzhou, Guangdong 510642 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Xie","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology , Tianjin 300308 , China"},{"name":"Institute of Subtropical Agriculture, Chinese Academy of Science, Research Center for Healthy Breeding of Livestock and Poultry , Changsha, Hunan 410125 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic Biology , Tianjin 300308 , China"},{"name":"Institute of Subtropical Agriculture, Chinese Academy of Science, Research Center for Healthy Breeding of Livestock and Poultry , Changsha, Hunan 410125 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-1807","authenticated-orcid":false,"given":"Chengquan","family":"Tan","sequence":"additional","affiliation":[{"name":"Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, National Center of Technology Innovation for Synthetic 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